Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes.

Autor: Mudumbi KC; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA. Electronic address: krishna.mudumbi@yale.edu., Burns EA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Schodt DJ; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA., Petrova ZO; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Kiyatkin A; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Kim LW; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Mangiacapre EM; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Ortiz-Caraveo I; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA., Rivera Ortiz H; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Hu C; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Ashtekar KD; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA., Lidke KA; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87106, USA., Lidke DS; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. Electronic address: dlidke@salud.unm.edu., Lemmon MA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT 06516, USA. Electronic address: mark.lemmon@yale.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113603. Date of Electronic Publication: 2023 Dec 20.

Structural basis for ligand reception by anaplastic lymphoma kinase.

Autor: Li T; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Stayrook SE; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Tsutsui Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Zhang J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Wang Y; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Li H; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Proffitt A; Celldex Therapeutics, New Haven, CT, USA., Krimmer SG; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA., Ahmed M; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA., Belliveau O; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Walker IX; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Mudumbi KC; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Suzuki Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA., Lax I; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Alvarado D; Celldex Therapeutics, New Haven, CT, USA., Lemmon MA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA., Klein DE; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA. daryl.klein@yale.edu.; Yale Cancer Biology Institute, Yale University, West Haven, CT, USA. daryl.klein@yale.edu.

Publikováno v: Nature [Nature] 2021 Dec; Vol. 600 (7887), pp. 148-152. Date of Electronic Publication: 2021 Nov 24.

Casting a Wider Net: Differentiating between Inner Nuclear Envelope and Outer Nuclear Envelope Transmembrane Proteins.

Autor: Tingey M; Department of Biology, Temple University, Philadelphia, PA 19121, USA. Mark.Tingey@temple.edu., Mudumbi KC; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA. Krishna.Mudumbi@yale.edu.; Yale Cancer Biology Institute, Yale University, New Haven, CT 06516, USA. Krishna.Mudumbi@yale.edu., Schirmer EC; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH8 3BF, UK. E.Schirmer@ed.ac.uk., Yang W; Department of Biology, Temple University, Philadelphia, PA 19121, USA. Weidong.Yang@temple.edu.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2019 Oct 23; Vol. 20 (21). Date of Electronic Publication: 2019 Oct 23.

Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution.

Autor: Mudumbi KC; Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA., Schirmer EC; The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK., Yang W; Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA.

Publikováno v: Nature communications [Nat Commun] 2016 Aug 25; Vol. 7, pp. 12562. Date of Electronic Publication: 2016 Aug 25.

The pathogenic A391E mutation in FGFR3 induces a structural change in the transmembrane domain dimer.

Autor: Mudumbi KC; Department of Biology, Saint Joseph's University, Philadelphia, PA 19107, USA., Julius A, Herrmann J, Li E

Publikováno v: The Journal of membrane biology [J Membr Biol] 2013 Jun; Vol. 246 (6), pp. 487-93. Date of Electronic Publication: 2013 Jun 01.