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Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.

Autor: Wong H; Genentech Inc., South San Francisco, CA, USA. Electronic address: harvey.wong@ubc.ca., Bohnert T; Biogen-Idec, Cambridge, MA, USA., Damian-Iordache V; GlaxoSmithKline, Upper Merion, PA, USA., Gibson C; PPDM, Merck Research Laboratories, West Point, PA, USA., Hsu CP; PKDM, Amgen Inc., Thousand Oaks, CA, USA., Krishnatry AS; GlaxoSmithKline, Upper Merion, PA, USA., Liederer BM; Genentech Inc., South San Francisco, CA, USA., Lin J; Sunovion, Marlborough, MA, USA., Lu Q; Sanofi, Bridgewater, NJ, USA., Mettetal JT; Drug Safety and Metabolism, Astra-Zeneca, Waltham, MA. USA., Mudra DR; Eli Lilly and Company, Indianapolis, Indiana, USA., Nijsen MJMA; Abbvie, North Chicago, IL, USA., Schroeder P; Biogen-Idec, Cambridge, MA, USA., Schuck E; Eisai Inc, Woodcliff Lake, NJ, USA., Suryawanshi S; Bristol-Myers Squibb, Princeton, NJ, USA., Trapa P; Pfizer Inc., Cambridge, MA, USA., Tsai A; Vertex Pharmaceuticals Incorporated, Boston, MA, USA., Wang H; Bristol-Myers Squibb, Princeton, NJ, USA., Wu F; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.

Publikováno v: Drug discovery today [Drug Discov Today] 2017 Oct; Vol. 22 (10), pp. 1447-1459. Date of Electronic Publication: 2017 May 02.

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

Autor: Partridge KM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA. Electronic address: Partridge_Katherine@lilly.com., Antonysamy S; Eli Lilly Biotechnology Center, San Diego, CA 92121, USA., Bhattachar SN; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Chandrasekhar S; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA; Retired., Fisher MJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Fretland A; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA; Present/Permanent address: Discovery Sciences, Oncology Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA., Gooding K; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA; Retired., Harvey A; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA; Retired., Hughes NE; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Kuklish SL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Luz JG; Eli Lilly Biotechnology Center, San Diego, CA 92121, USA., Manninen PR; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., McGee JE; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Mudra DR; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Navarro A; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Norman BH; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Quimby SJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Schiffler MA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Sloan AV; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Warshawsky AM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Weller JM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., York JS; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA., Yu XP; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Mar 15; Vol. 27 (6), pp. 1478-1483. Date of Electronic Publication: 2016 Nov 07.

Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.

Autor: Wiley MR; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Durham TB; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Adams LA; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Chambers MG; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Lin C; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Liu C; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Marimuthu J; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Mitchell PG; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Mudra DR; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Swearingen CA; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Toth JL; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Weller JM; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Thirunavukkarasu K; Eli Lilly and Company , Lilly Corporate Center, Indianapolis, Indiana 46285, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Jun 23; Vol. 59 (12), pp. 5810-22. Date of Electronic Publication: 2016 Jun 09.