Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mudher Albassam"'
Autor:
Mudher Albassam, Björn Jacobsen, Barbara Lenz, Christian Freichel, Jean-Christophe Hoflack, Anne Eichinger-Chapelon, Andreas Brink
Publikováno v:
Toxicologic Pathology. 47:138-149
The chemically induced accumulation of α2u-globulin protein in male rats causes specific renal lesions and subsequent nephropathy. Herein, we report additional parallel findings in the kidney of male rats consistent with obstructive and retrograde n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb549a6479c04ff2533eaaa8cafadca2
https://doi.org/10.1177/0192623318816039
https://doi.org/10.1177/0192623318816039
Autor:
Roland F Staack, Rosario Garrido, Elke-Astrid Atzpodien, Michael Winter, Nicole Justies, Franziska Regenass-Lechner, Gregor Jordan, Wolfgang F. Richter, Thomas Singer, Jean-Luc Mary, Mudher Albassam, Anja Langenkamp
Publikováno v:
Toxicological Sciences. 150:378-389
High density lipoprotein (HDL)-targeted therapies, which promote cholesterol efflux from cells, are currently in development for reducing cardiovascular events in acute coronary syndrome. Human apolipoprotein A-I (apoA-I), the major HDL protein, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07193187bafde1b61910707e55a0109
https://doi.org/10.1093/toxsci/kfw004
https://doi.org/10.1093/toxsci/kfw004
Autor:
Feng Hong, Valerie Hughes, Denise Knapp, Natalie D. Keirstead, Mudher Albassam, Adrian Roth, Igor Mikaelian, Cristina Bertinetti-Lapatki
Publikováno v:
Toxicologic Pathology. 43:984-994
Recombinant interleukin-2 (rIL-2) administration in oncology indications is hampered by vascular toxicity, which presents as a vascular leak syndrome. We used this aspect of the toxicity of rIL-2 to evaluate candidate biomarkers of drug-induced vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e99aacb836be7ff466398e2416bbf1
https://doi.org/10.1177/0192623315601245
https://doi.org/10.1177/0192623315601245
Autor:
Simone Schadt, Andreas Brink, Raphael Zurbach, Monira Siam, Thomas Singer, Franz Schuler, Bernd Steinhuber, Simon Bassett, Urs Niederhauser, Pierre Maliver, Anne De Paepe, Barbara Lenz, Christoph Funk, Anne Eichinger-Chapelon, Mudher Albassam, Rachel Neff
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 163(2)
A number of drugs can cause precipitates within renal tubules leading to crystal nephropathy. Crystal nephropathy is usually an exposure-related finding and is not uncommon in preclinical studies, where high doses are tested. An understanding of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21e2bc0009504973d537cbe6f708c75
https://pubmed.ncbi.nlm.nih.gov/28329870
https://pubmed.ncbi.nlm.nih.gov/28329870
Publikováno v:
Biotechnic & Histochemistry. 89:259-266
MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression by binding to complementary sequences on target messenger RNA transcripts. Changes in the expression levels of specific miRNAs have been associated with a variety of disease c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f23f95696e7627ddfc0d5d117ff18b1
https://doi.org/10.3109/10520295.2013.839825
https://doi.org/10.3109/10520295.2013.839825
Autor:
Michele Bortolini, Saray Stancic, Mudher Albassam, Neil Kaplowitz, Paul B. Watkins, Alberto Corsini, Laura Suter, Patricia E. Ganey, Baolian Liu, Dominique Pessayre, Robert A. Roth, Changqing Ju
Publikováno v:
Drug Safety. 35:1099-1117
Current key challenges and controversies encountered in the identification of potentially hepatotoxic drugs and the assessment of drug-induced liver injury (DILI) are covered in this article. There is substantial debate over the classification of DIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5752ab3ac049f486bc1940bd18070288
https://doi.org/10.1007/bf03261997
https://doi.org/10.1007/bf03261997
Autor:
Timothy Anderson, Marc Bailie, David Pegg, Zbigniew W. Wojcinski, Eric Olsen, Steven Duddy, Stephen Foote, Kay A. Criswell, Mudher Albassam
Publikováno v:
Toxicological Sciences. 128:22-41
In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats. Investigative studies, ranging in length from 24 h to 12 months, were conducted in mice (1000 or 5000 mg/kg) and rats (900 mg/kg) to evaluate a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbacd8f07e7352631ecae9d6ae2f25e
https://doi.org/10.1093/toxsci/kfs147
https://doi.org/10.1093/toxsci/kfs147
Publikováno v:
British Journal of Pharmacology. 165:2771-2786
BACKGROUND AND PURPOSE Drug candidates must be thoroughly investigated for their potential cardiac side effects. During the course of routine toxicological assessment, the compound RO5657, a CCR5 antagonist, was discovered to have the rare liability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f580fbf3355d8ca194e11d8ab09cd11
https://doi.org/10.1111/j.1476-5381.2011.01756.x
https://doi.org/10.1111/j.1476-5381.2011.01756.x
Autor:
Adrian J. Fretland, Thomas Singer, Mudher Albassam, Jennifer Fretland, Jianhua Tao, Tanja S. Zabka, Rosario Garrido, Kyle L. Kolaja, Mark R. Fielden
Publikováno v:
Toxicologic Pathology. 39:664-677
During routine safety evaluation of RO2910, a non-nucleoside reverse transcriptase inhibitor for HIV infection, histopathology findings concurrent with robust hepatocellular induction occurred in multiple organs, including a unique, albeit related, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de1061159a01ad505be2d0e7ddbb9f1
https://doi.org/10.1177/0192623311406934
https://doi.org/10.1177/0192623311406934
Publikováno v:
Toxicologic Pathology. 37:814-818
A previously undescribed spontaneous cardiomyopathy was identified by routine light microscopic examination of the heart from four clinically healthy purpose-bred cynomolgus monkeys that ranged from four to nine years of age and included 2 males and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915b0d3ede1bf59d45760b71be2d649a
https://doi.org/10.1177/0192623309345692
https://doi.org/10.1177/0192623309345692