Zobrazeno 1 - 10
of 894
pro vyhledávání: '"Mudaliar P"'
Target selection is crucial in pharmaceutical drug discovery, directly influencing clinical trial success. Despite its importance, drug development remains resource-intensive, often taking over a decade with significant financial costs. High failure
Externí odkaz:
http://arxiv.org/abs/2409.16327
Parkinson's disease is a progressive and slowly developing neurodegenerative disease, characterized by dopaminergic neuron loss in the substantia nigra region of the brain. Despite extensive research by scientists, there is not yet a cure to this pro
Externí odkaz:
http://arxiv.org/abs/2404.08711
Autor:
Sritharan, Sivaguru S., Mudaliar, Saba
In this paper we consider classical and quantum spin systems on discrete lattices and in Euclidean spaces, modeled by infinite dimensional stochastic diffusions in Hilbert spaces. Existence and uniqueness of various notions of solutions, existence an
Externí odkaz:
http://arxiv.org/abs/2309.14143
Publikováno v:
Pediatric Hematology Oncology Journal, Vol 9, Iss 4, Pp 250-254 (2024)
Background: Evans syndrome is an autoimmune condition that manifests as two or more autoimmune cytopenia. We present a case of Evans syndrome diagnosed with an underlying skeletal dysplasia; Schimke immune-osseous dysplasia (SIOD). The condition is c
Externí odkaz:
https://doaj.org/article/a76fb8d6295d4c8fbada6b056cc656f3
Publikováno v:
Pediatric Hematology Oncology Journal, Vol 9, Iss 4, Pp 235-243 (2024)
Red blood cell enzyme deficiencies are a rare category of hemolytic anaemia that typically present in children with varying degrees of hemolysis, indirect hyperbilirubinemia and splenomegaly. Glucose 6-phosphate dehydrogenase (G6PD) is the most commo
Externí odkaz:
https://doaj.org/article/5f0fdbcacd754354a437f28aefb7d1d1
Autor:
Ritika Khurana, Sangeeta Mudaliar
Publikováno v:
Pediatric Hematology Oncology Journal, Vol 9, Iss 2, Pp 101-104 (2024)
Mitapivat is the first in class oral allosteric activator of pyruvate kinase enzyme, leading to increased ATP production. Since red blood cells (RBC) rely on anaerobic metabolism, converting phosphoenolpyruvate to pyruvate in Embden– Meyerhof glyco
Externí odkaz:
https://doaj.org/article/0f9179ff890443a3a6ab60f2f88bcece
Autor:
Sritharan, Sivaguru S., Mudaliar, Saba
This paper identifies certain interesting mathematical problems of stochastic quantization type in the modeling of Laser propagation through turbulent media. In some of the typical physical contexts the problem reduces to stochastic Schrodinger equat
Externí odkaz:
http://arxiv.org/abs/2301.00300
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract This study explores how machine-learning can be used to predict chromatographic retention times (RT) for the analysis of small molecules, with the objective of identifying a machine-learning framework with the robustness required to support
Externí odkaz:
https://doaj.org/article/7809f1803283419293563e65a4899082
Autor:
Ambreen Pandrowala, Sanna Khan, Darshan Kataria, Manasa Kakunje, Varsha Mishra, Dhruv Mamtora, Sangeeta Mudaliar, Minnie Bodhanwala, Bharat Agarwal, Prashant Hiwarkar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Although graft T cells assist in engraftment, mediate antiviral immune-reconstitution, and cause graft-versus-host disease, graft size is not determined by T-cell content of the graft. The conventional method of graft size determination base
Externí odkaz:
https://doaj.org/article/b5ba33fa012e4043923f8d3e79eddf03
Publikováno v:
JGH Open, Vol 7, Iss 10, Pp 690-697 (2023)
Abstract Background and Aims Fontan‐associated liver disease (FALD) is a long‐term complication of the Fontan procedure. Guidelines recommend elastography, but the utility of transient elastography (TE) and two‐dimensional shear wave elastograp
Externí odkaz:
https://doaj.org/article/054cc86774be4a7fa325939219eafa7a