Zobrazeno 1 - 10
of 904
pro vyhledávání: '"Mucus layer"'
Intratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers
Autor:
Tatiana V. Karpinets, Yoshitsugu Mitani, Chia-Chi Chang, Xiaogang Wu, Xingzhi Song, Ivonne I. Flores, Lauren K. McDaniel, Yasmine M. Hoballah, Fabiana J. Veguilla, Renata Ferrarotto, Lauren E. Colbert, Nadim J. Ajami, Robert R. Jenq, Jianhua Zhang, Andrew P. Futreal, Adel K. El-Naggar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in ACC remains limited. We investigat
Externí odkaz:
https://doaj.org/article/e1c7c9a7f34347698b377e27634d3bc8
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intestine is unclear. We performed single-nuclear RNA sequencing (snRNAseq) in the pinch biopsies of terminal ileum of four
Externí odkaz:
https://doaj.org/article/e6ba8168b96f468e932bfeffd78dbda4
Autor:
Amina Bourragat, Quentin Escoula, Sandrine Bellenger, Olivier Zemb, Martin Beaumont, Killian Chaumonnot, Jean-Pierre Farine, Emmanuel Jacotot, Aline Bonnotte, Laure Avoscan, Jeanine Lherminier, Kangjia Luo, Michel Narce, Jérôme Bellenger
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTHigh-fat diets alter gut barrier integrity, leading to endotoxemia by impacting epithelial functions and inducing endoplasmic reticulum (ER) stress in intestinal secretory goblet cells. Indeed, ER stress, which is an important contributor to
Externí odkaz:
https://doaj.org/article/b3d0b6ff65bb40b1b2dc484b33e0e708
Publikováno v:
Shipin Kexue, Vol 44, Iss 24, Pp 16-25 (2023)
GLD/HP-β-CD inclusion complexes were prepared by encapsulating glabridin (GLD) with hydroxypropyl (HP) and β-cyclodextrin (β-CD) to improve the solubility of GLD in water. The morphology, the existing form of GLD, the interaction between GLD and H
Externí odkaz:
https://doaj.org/article/dadeb32c24a6473d973b2263f14eb969
Publikováno v:
Shipin Kexue, Vol 44, Iss 21, Pp 23-34 (2023)
The in vivo absorption of nanocarriers is a complex process, which is affected by the bioabsorption barrier. It is doubtful whether nanopreparations can promote the absorption and utilization of bioactive molecules. In this study, soy protein isolate
Externí odkaz:
https://doaj.org/article/f146270c70854e47a86412fbbcf0c071
Autor:
Esther Mezhibovsky, Yue Wu, Fiona G. Bawagan, Kevin M. Tveter, Samantha Szeto, Diana Roopchand
Publikováno v:
AIMS Microbiology, Vol 8, Iss 4, Pp 544-565 (2022)
A healthy gastrointestinal tract functions as a highly selective barrier, allowing the absorption of nutrients and metabolites while preventing gut bacteria and other xenobiotic compounds from entering host circulation and tissues. The intestinal epi
Externí odkaz:
https://doaj.org/article/d143650a43a740bd8e59d3736315dc6e
Autor:
Tatiana V. Karpinets, Xiaogang Wu, Travis Solley, Molly B. El Alam, Travis T. Sims, Kyoko Yoshida-Court, Erica Lynn, Mustapha Ahmed-Kaddar, Greyson Biegert, Jingyan Yue, Xingzhi Song, Huandong Sun, Joseph F. Petrosino, Melissa P. Mezzari, Pablo Okhuysen, Patricia J. Eifel, Anuja Jhingran, Lilie L. Lin, Kathleen M. Schmeler, Lois Ramondetta, Nadim Ajami, Robert R. Jenq, Andrew Futreal, Jianhua Zhang, Ann H. Klopp, Lauren E. Colbert
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background Gut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, and increased gut diversity is associated with improved outcomes after treatment. We proposed that functions of specific micr
Externí odkaz:
https://doaj.org/article/0aaae9f1b6404c15b3d264ad029b00a4
Autor:
Bing Xia, Ruqing Zhong, Weida Wu, Chengzeng Luo, Qingshi Meng, Qingtao Gao, Yong Zhao, Liang Chen, Sheng Zhang, Xin Zhao, Hongfu Zhang
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Background Post-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The intestinal epithelial cells and microbiota reciprocally regulate each other in order to maintain int
Externí odkaz:
https://doaj.org/article/e80565bae465454a853e9c562fe0c6e3
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2708 (2023)
Oral administration of active pharmaceutical ingredients is desirable because it is easy, safe, painless, and can be performed by patients, resulting in good medication adherence. The mucus layer in the gastrointestinal (GI) tract generally acts as a
Externí odkaz:
https://doaj.org/article/8c3354b42eaa4cbe80f4ffbb662ada52
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2714 (2023)
Because of the increasing sophistication of formulation technology and the increasing polymerization of compounds directed toward undruggable drug targets, the influence of the mucus layer on gastrointestinal drug absorption has received renewed atte
Externí odkaz:
https://doaj.org/article/66f72354e8b64cf497345dbe34c67128