AMPK activation protects against prostate cancer by inducing a catabolic cellular state.

Autor: Penfold L; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK. Electronic address: l.penfold12@lms.mrc.ac.uk., Woods A; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Pollard AE; Institute of Clinical Sciences, Imperial College London, London, UK., Arizanova J; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Pascual-Navarro E; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Muckett PJ; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Dore MH; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Montoya A; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Whilding C; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Fets L; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Mokochinski J; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK., Constantin TA; Imperial Centre for Translational and Experimental Medicine, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK., Varela-Carver A; Imperial Centre for Translational and Experimental Medicine, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK., Leach DA; Imperial Centre for Translational and Experimental Medicine, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK., Bevan CL; Imperial Centre for Translational and Experimental Medicine, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK., Nikitin AY; Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, NY, USA., Hall Z; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, UK., Carling D; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, London, UK. Electronic address: dcarling@imperial.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2023 Apr 25; Vol. 42 (4), pp. 112396. Date of Electronic Publication: 2023 Apr 15.

AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.

Autor: Pollard AE; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK.; Discovery Sciences IMED Biotech Unit, AstraZeneca, Cambridge, UK., Martins L; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Muckett PJ; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Khadayate S; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Bornot A; Discovery Sciences IMED Biotech Unit, AstraZeneca, Cambridge, UK., Clausen M; Discovery Sciences IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Admyre T; Discovery Sciences IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Bjursell M; Discovery Sciences IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Fiadeiro R; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Wilson L; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Whilding C; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Kotiadis VN; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Research, University College London, London, UK., Duchen MR; Department of Cell and Developmental Biology and UCL Consortium for Mitochondrial Research, University College London, London, UK., Sutton D; Drug Safety and Metabolism IMED Biotech Unit, AstraZeneca, Babraham, UK., Penfold L; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Sardini A; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK., Bohlooly-Y M; Discovery Sciences IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Smith DM; Discovery Sciences IMED Biotech Unit, AstraZeneca, Cambridge, UK., Read JA; Discovery Sciences IMED Biotech Unit, AstraZeneca, Cambridge, UK., Snowden MA; Discovery Sciences IMED Biotech Unit, AstraZeneca, Cambridge, UK., Woods A; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK. angela.woods@lms.mrc.ac.uk., Carling D; MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK. david.carling@lms.mrc.ac.uk.; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, UK. david.carling@lms.mrc.ac.uk.

Publikováno v: Nature metabolism [Nat Metab] 2019 Mar; Vol. 1 (3), pp. 340-349. Date of Electronic Publication: 2019 Feb 25.

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

Autor: Thornton C; Cellular Stress Group, MRC Clinical Sciences Centre, London, UK. claire.thornton@imperial.ac.uk, Bright NJ, Sastre M, Muckett PJ, Carling D

Publikováno v: The Biochemical journal [Biochem J] 2011 Mar 15; Vol. 434 (3), pp. 503-12.

LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis.

Autor: Denison FC; Medical Research Council's Clinical Sciences Centre, Imperial College, London, United Kingdom., Smith LB, Muckett PJ, O'Hara L, Carling D, Woods A

Publikováno v: PloS one [PLoS One] 2011; Vol. 6 (12), pp. e28306. Date of Electronic Publication: 2011 Dec 01.