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Akademický článek

Evidence for interleukin-5 in nasal polyps in aspirin-induced asthma

Autor: Norihisa Ogata, Keisuke Masuyama, Makoto Yoshida, Hidetoshi Asai, Muchun Wang, Yasuhiro Samejima, Masao Eura, Noriaki Tsunoda, Takeru Ishikawa

Publikováno v: Allergology International, Vol 46, Iss 3, Pp 161-165 (1997)

Aspirin-induced asthma is often accompanied by nasal polyps, in which tissue eosinophils are abundant and activated. However, the mechanism of eosinophil infiltration remains unknown. We encountered two aspirin-induced asthma patients with nasal poly

Externí odkaz: https://doaj.org/article/ab8aafaec2f5462bab07cc07dc9fa3d9

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KLF2 protects BV2 microglial cells against oxygen and glucose deprivation injury by modulating BDNF/TrkB pathway

Autor: Muchun Wang, Jingbin Zhou, Dongfeng Deng

Publikováno v: Gene. 735

Cerebral ischemia injury is common in cerebral ischemic disease, and treatment options remain limited. Krueppel-like factor 2 (KLF2) is reported to negatively regulate inflammation in several ischemic diseases. Our study aimed to investigate the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9f3866bfe6903cb7ac0322ee730cc5
https://pubmed.ncbi.nlm.nih.gov/31821872

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Abstract 5640: Targeting tumor-promoting inflammation (TPI) via the IL-1βpathway for cancer immunotherapy

Autor: Tong Luo, Anne-Marie Martin, Catherine Anne Sabatos-Peyton, Valerie Rezek, Alexander Savchenko, Marc Pelletier, Muchun Wang, Vanessa Rodrik-Outmezguine, Pushpa Jayaraman, John Millholland, Scott G. Kitchen, Rohan Diwanji, Wong Connie C, Jason Baum, Neil A. O'Brien, Kristine Rose, Glenn Dranoff, Elizabeth Choi, Ronald Linnartz

Publikováno v: Cancer Research. 80:5640-5640

Introduction: TPI is a hallmark of cancer and plays a pivotal role in tumor initiation, development, progression, and invasiveness. High levels of tumor-promoting inflammatory cytokines e.g. IL-1β and IL-6 are associated with advanced malignancies a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75de7170d1da088e4701c6ef37addc49
https://doi.org/10.1158/1538-7445.am2020-5640

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c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas

Autor: Jingbin Zhou, Dongfeng Deng, Muchun Wang

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 107

Glioma is one of the most aggressive and lethal human cancers in central nervous system (CNS). Recent studies have identified many dysregulated microRNAs (miRNA, miR) in human glioma, which are a class of small non-coding RNA molecules. Increasing da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3496ea81624d386ce7d6acd421b194fb
https://pubmed.ncbi.nlm.nih.gov/30257388

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Abstract C103: Targeting IL-1β pathway for cancer immunotherapy

Autor: Kristine Rose, Ronald Linnartz, Neil A. O'Brien, Vanessa Rodrik-Outmezguine, Marc Pelletier, Pushpa Jayaraman, John Millholland, Rohan Diwanji, Elizabeth Choi, Muchun Wang, Wong Connie C, Alexander Savchenko, Scott G. Kitchen, Jason Baum, Tong Luo, Catherine Anne Sabatos-Peyton, Anne-Marie Martin, Valerie Rezek, Glenn Dranoff

Publikováno v: Molecular Cancer Therapeutics. 18:C103-C103

Introduction: Inflammation is a hallmark of cancer wherein diverse immune cells exert either pro- or antitumor properties and affect therapeutic resistance (Ritter B et al, JEM 2019). High concentrations of tumor-promoting inflammatory cytokines such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5434b4a173db97b4cfc9d7b8bdf3c9f6
https://doi.org/10.1158/1535-7163.targ-19-c103

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Abstract 5775: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER+ breast cancer models

Publikováno v: Cancer Research. 78:5775-5775

Nearly 70% or more of newly diagnosed cases of breast cancer (BC) are estrogen receptor positive (ER+) where endocrine therapy is a primary treatment. However, substantial evidence describes a continued role of ER signaling in tumor progression, wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a67ba81130dd15685d38e5e0aa1141af
https://doi.org/10.1158/1538-7445.am2018-5775

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Phosphorylation of PPAR? via active ERK1/2 leads to its physical association with p65 and inhibition of NF-??

Autor: Mai He, Muchun Wang, Lawrence E. Harrison, J. Patrick O'Connor, Fei Chen, Tushar Tripathi

Publikováno v: Journal of Cellular Biochemistry. 90:732-744

Peroxisome proliferator-activated receptors (PPAR) are novel nuclear receptors and PPARgamma ligands have been shown to produce pro-apoptotic effects in many cancer cell types, including colon cancer. PPARgamma ligands exert their effect through PPAR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b94ec15af7a71956d362ce6cf8f867e2
https://doi.org/10.1002/jcb.10668

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Characterization of nicotinic acetylcholine receptor-mediated noradrenaline release from the isolated rat stomach

Autor: Masakazu Hirata, Yoshinori Murakami, Muchun Wang, Shoshiro Okada, Kunihiko Yokotani

Publikováno v: European Journal of Pharmacology. 402:223-229

We characterized nicotinic acetylcholine receptor-mediated noradrenaline release from the isolated, vascularly perfused rat stomach. The stomach was perfused via the coeliac artery with Krebs-Ringer solution at a constant flow rate of 4 ml per minute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9018f7dc652cda19db559f774c817ee
https://doi.org/10.1016/s0014-2999(00)00533-1

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