Výsledky vyhledávání - "Mubark D. Mebrat"

Akademický článek

Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller

Autor: Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Studies of folded-to-misfolded transitions using model protein systems reveal a range of unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here, we probe the relationship between unfolding and aggregation

Externí odkaz: https://doaj.org/article/d4c43b083a34447bb38dec82f348044d

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Akademický článek

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

Autor: Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins. Here authors developed a computational approach t

Externí odkaz: https://doaj.org/article/9f68b130500b474887f6a03663bb2f12

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A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation

Autor: Aerial M. Owens, Wade D. Van Horn, Dustin D. Luu, Mubark D. Mebrat

Publikováno v: Temperature (Austin)

TRPV1 is a polymodal receptor ion channel that is best known to function as a molecular thermometer. It is activated in diverse ways, including by heat, protons (low pH), and vanilloid compounds, such as capsaicin. In this review, we summarize molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2c3dfd0b43cfce1b67547de0b2e9bb
https://doi.org/10.1080/23328940.2021.1983354

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Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

Autor: Sergio Martínez-Rodríguez, Valeria A. Risso, Tushar Modi, Jose M. Sanchez-Ruiz, Mubark D. Mebrat, Wade D. Van Horn, S. Banu Ozkan, Jose A. Gavira

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
'Nature Communications ', vol: 12, pages: 1852-1-1852-14 (2021)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada

W.D.V.H. acknowledges support from National Institutes of Health (Grant: R01GM112077). S.B.O. acknowledges support from the Gordon and Betty Moore Foundations and National Science Foundation (Awards: 1715591 and 1901709). J.M.S.R. acknowledges suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7bb312fe1d0a0603233bca0b3c4873
https://doaj.org/article/9f68b130500b474887f6a03663bb2f12

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Near-infrared nerve-binding fluorophores for buried nerve tissue imaging

Autor: Alexander L. Antaris, Ian E. McDowall, Catherine H. Kitts, Meaghan E. McCoy, Summer L. Gibbs, Connor W. Barth, Antonio R. Montaño, Broderick J. House, Jonathan M. Sorger, S. N. Galvis, Lei G. Wang, Mubark D. Mebrat

Publikováno v: Science translational medicine. 12(542)

Nerve-binding fluorophores with near-infrared (NIR; 650 to 900 nm) emission could reduce iatrogenic nerve injury rates by providing surgeons precise, real-time visualization of the peripheral nervous system. Unfortunately, current systemically admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e672e0eb2bd67e6cb5152a26a8a10cb4
https://pubmed.ncbi.nlm.nih.gov/32376766

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Characterization of HTRPM8 Conformational Dynamic Utilizing Solution NMR

Autor: Danielle Morelan, Mubark D. Mebrat, Jacob K. Hilton, Wade D. Van Horn

Publikováno v: Biophysical Journal. 118:413a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d57371ce1874b296864fb4732c03282d
https://doi.org/10.1016/j.bpj.2019.11.2336

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