Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Mubarak A. Alamri"'
Autor:
Chandni Hayat, Vetriselvan Subramaniyan, Mubarak A. Alamri, Ling Shing Wong, Asaad Khalid, Ashraf N. Abdalla, Sahib Gul Afridi, Vinoth Kumarasamy, Abdul Wadood
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-18 (2024)
Abstract Nod-like receptor protein 3 (NLRP-3), is an intracellular sensor that is involved in inflammasome activation, and the aberrant expression of NLRP3 is responsible for diabetes mellitus, its complications, and many other inflammatory diseases.
Externí odkaz:
https://doaj.org/article/49d8b02860a943b69be41748a82ff4e5
Autor:
Amar Ajmal, Hind A Alkhatabi, Roaa M. Alreemi, Mubarak A. Alamri, Asaad Khalid, Ashraf N. Abdalla, Bader S. Alotaibi, Abdul Wadood
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Lung cancer is a disease with a high mortality rate and it is the number one cause of cancer death globally. Approximately 12–14% of non-small cell lung cancers are caused by mutations in KRASG12C. The KRASG12C is one of the most prevalent
Externí odkaz:
https://doaj.org/article/cc592fd289c745519d9d8ac7abf9ade9
Autor:
Mubarak A. Alamri, Mohammed Merae Alshahrani, Abdullah S. Alawam, Souparno Paria, Kalyan Kumar Sen, Subhasis Banerjee, Supriyo Saha
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 8, Pp 103285- (2024)
Vascular Endothelial Growth Factor (VEGF) has a greater impact on carcinogenesis, and it is the most significant receptor in mediating the mutagenesis and permeability of endothelial cells. Here, we report the identification of potential VEGFR-2 inhi
Externí odkaz:
https://doaj.org/article/da0b673915764443ab2c949ad47b0b3a
Autor:
Huma Rafiq, Junjian Hu, Mohammed Ageeli Hakami, Ali Hazazi, Mubarak A. Alamri, Hind A. Alkhatabi, Arif Mahmood, Bader S. Alotaibi, Abdul Wadood, Xiaoyun Huang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The signal transducer and activator of transcription 3 (STAT3) plays a fundamental role in the growth and regulation of cellular life. Activation and over-expression of STAT3 have been implicated in many cancers including solid blood tumors
Externí odkaz:
https://doaj.org/article/62990f78628f4c37ac1381e7adbcb989
Autor:
Mubarak A. Alamri, Obaid Afzal, Md Jawaid Akhtar, Shahid Karim, Mohammed Husain, Manal A. Alossaimi, Yassine Riadi
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105384- (2024)
A series of new quinazolinone derivatives (5a-l) were designed as 3CL protease inhibitors for SARS-CoV-2 infection. The designed derivatives were efficiently synthesized by S-alkylation/arylation of an intermediate, 6-fluoro-3-(4-fluorophenyl)-2-merc
Externí odkaz:
https://doaj.org/article/94c9f3d23ffc4258968910018fd565c3
Autor:
Mubarak A. Alamri
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 6, Pp 1125-1138 (2023)
The incidence of Hepatocellular Carcinoma (HCC) in Saudi Arabia is not surprising given the relatively high prevalence of hepatitis C virus (HCV) infection. Hepatitis C is also common in Saudi Arabia with a prevalence rate of 1% to 3% of the populati
Externí odkaz:
https://doaj.org/article/062d6518a8a34db89a0c774d64d53da6
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 11, Pp 101802- (2023)
Inflammation is a nonspecific immune response against injury caused by a harmful agent that strives to restore tissue function and homeostasis. Dodonaea angustifolia L.f. (Sapindaceae) is a medium-sized shrub used to treat a variety of diseases in tr
Externí odkaz:
https://doaj.org/article/0ebe492c7d064d4fa25897cbe209d087
Autor:
Abdullah S. Alawam, Hadil Sultan Alawam, Mohammed Merae Alshahrani, Maher S. Alwethaynani, Lina M. Alneghery, Mubarak A. Alamri
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 34 (2024)
The Marburg virus (MBV), a deadly pathogen, poses a serious threat to world health due to the lack of effective treatments, calling for an immediate search for targeted and efficient treatments. In this study, we focused on compounds originating from
Externí odkaz:
https://doaj.org/article/bda832ed12e34c59a81fed496580b3c3
Autor:
Israr Fatima, Sajjad Ahmad, Mubarak A. Alamri, Muhammad Usman Mirza, Muhammad Tahir ul Qamar, Abdur Rehman, Farah Shahid, Eid A. Alatawi, Faris F. Aba Alkhayl, Wafa Abdullah Al-Megrin, Ahmad Almatroudi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The Rift Valley fever virus (RVFV) is a zoonotic arbovirus and pathogenic to both humans and animals. Currently, no proven effective RVFV drugs or licensed vaccine are available for human or animal use. Hence, there is an urgent need to deve
Externí odkaz:
https://doaj.org/article/63024dee059f443586b2dd9e3a287886
Autor:
Amal M. Alosaimy, Amr S. Abouzied, Amani M. R. Alsaedi, Ahmed Alafnan, Abdulwahab Alamri, Mubarak A. Alamri, Mohammed Khaled Bin Break, Rehab Sabour, Thoraya A. Farghaly
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104569- (2023)
Inhibition of Heat-shock protein 90 (Hsp90) is considered an attractive route in fighting against cancer proliferation. Herein, new indene derivatives targeting Hsp90 were synthesized, and biologically evaluated. The new series of indeno-pyrimidine a
Externí odkaz:
https://doaj.org/article/c9b5c632c22e4a7981ef702db198bbcb