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Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis

Autor: Yu-bao Qiu, Bin-bin Wan, Gang Liu, Ya-xian Wu, Dan Chen, Mu-dan Lu, Jun-liang Chen, Ren-qiang Yu, Dao-zhen Chen, Qing-feng Pang

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-16 (2020)

Abstract Background Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which is caused by severe oxidative stress injury

Externí odkaz: https://doaj.org/article/5780605b65434064895990b6016c1db4

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ERK1/2-HNF4α axis is involved in epigallocatechin-3-gallate inhibition of HBV replication

Autor: Xing-hao Zhou, Mu-dan Lu, Tong-chun Xue, Yu-qi Li, Zi-yu Wang, Bo Gao, Zhi-wei Guo

Publikováno v: Acta Pharmacologica Sinica

Epigallocatechin gallate (EGCG), a major polyphenol in green tea, exhibits diverse biological activities. Previous studies show that EGCG could effectively suppress HBV gene expression and replication, but the role of EGCG in HBV replication and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59597830161de96614914518ab731fc6
http://europepmc.org/articles/PMC7468327

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Nrf2 protects against drowning-induced acute lung injury via inhibiting ferroptosis

Autor: Yu-bao Qiu, Bin-bin Wan, Gang Liu, Ya-xian Wu, Dan Chen, Mu-dan Lu, Jun-liang Chen, Ren-qiang Yu, Dao-zhen Chen, Qing-feng Pang

Background Drowning-induced acute lung injury (ALI) has been a major cause of accidental death worldwide. Severe oxidative stress injury is the key factor in drowning-induced ALI. The latest evidences indicate nuclear factor (erythroid-derived 2)-lik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3de994ed90cdbb61359f88eab2f67d3
https://doi.org/10.21203/rs.3.rs-34579/v1

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Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis

Autor: Bin-bin Wan, Ya-Xian Wu, Dan Chen, Qing-feng Pang, Si Zeng, Ying-ying Wang, Gang Liu, Mu-dan Lu, Yong-quan Chen, Zhi-Qi Gao, Hong-xu Sun

Publikováno v: International immunopharmacology. 90

Sophoricoside (SOP), an isoflavone glycoside isolated from seed of Sophora japonica L., has been reported to have various pharmacological activities, including anti-cancer, anti-allergy and anti-inflammation. However, the effect of SOP on lipopolysac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9973c057a229bd8ca62c52e5641c2dc
https://pubmed.ncbi.nlm.nih.gov/33249045

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Hyperoside suppresses hypoxia-induced A549 survival and proliferation through ferrous accumulation via AMPK/HO-1 axis

Autor: Qing-feng Pang, Ya-Xian Wu, Jun-Liang Chen, Gang Liu, Mu-dan Lu, Bin-bin Wan, Dan Chen, Yu-bao Qiu

Publikováno v: Phytomedicine. 67:153138

Background Hypoxia is commonly existed in tumors and lead to cancer cell chemo/radio-resistance. It is well-recognized that tumor hypoxia is a major challenge for the treatment of various solid tumors. Hyperoside (quercetin-3-O-galactoside, Hy) posse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d72c93645e10b25d4c3f29e284b2c87
https://doi.org/10.1016/j.phymed.2019.153138

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Curcumin ameliorates hepatic chronic inflammation induced by bile duct obstruction in mice through the activation of heme oxygenase-1

Autor: Yu-bao Qiu, Dan Chen, Mu-dan Lu, Chen Wu, Xue Wang, Jun-Liang Chen, Xue-qian Sun, Qing Chu, Qing-feng Pang, Dao-zhen Chen

Publikováno v: International Immunopharmacology. 78:106054

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9be03c46ff4e9ebf18f78022311c4c5
https://doi.org/10.1016/j.intimp.2019.106054

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[Expression and significance of c-jun-activation-domain binding protein (JAB1) in hepatocellular carcinoma]

Autor: Jun, Qin, Zhi-wei, Wang, Qi-chao, Ni, You, Wang, Li, Chen, Mu-dan, Lu, Ai-guo, Shen

Publikováno v: Zhonghua yi xue za zhi. 88(36)

to investigate the expression of c-jun-activation-domain binding protein (JAB1) in hepatocellular carcinoma (HCC) and the clinicopathologic significance thereof.Immunohistochemistry was used on 76 specimens of HCC tissues and native liver tissues adj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94f69389ce0150d28668ebff3119dde0
https://pubmed.ncbi.nlm.nih.gov/19080643

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[Growth inhibition of human leukemia cell line U937 by all-trans retinoic acid and its mechanism]

Autor: Yue-ming, Zhao, Yu-chan, Wang, Mu-dan, Lu, Ai-guo, Shen, Dong-mei, Zhang, Jian-xin, Lu, Chun, Cheng

Publikováno v: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 29(7)

To study the effect of all-trans retinoic acid (ATRA) on U937 cell growth and its mechanism.Cell cycle was detected by flow cytometry (FCM), expressions of cell cycle associated protein and the p27 related protein were detected by Western blot. The b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15e3a5575a8c8244d2037ebb20fda946
https://pubmed.ncbi.nlm.nih.gov/19035179

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