Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mu-Yun Gao"'
Autor:
Zhihong Huang, Jennifer Shaffer, Badry Bursulaya, Anna Galkin, Rie Kikkawa, Yelena Sarkisova, Su Hua, John Tellew, Yang Yang, Paul Vincent Rucker, Robert Epple, Jiqing Jiang, Nanxin Li, Chianelli Donatella, Jason Roland, Lintong Li, Sergio Briones, Casey J. N. Mathison, Valentina Molteni, Jacqueline Kinyamu-Akunda, Mu-Yun Gao, John Nelson, Christian C. Lee, Yun Feng Xie, Shailaja Kasibhatla, Chun Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] The selective inhibition of RET kinase as a treatment for relevant cancer types including lung adenocarcinoma has garnered considerable interest in recent years and prompted a variety of efforts toward the discovery of small-molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35f9c99597415f677d735f6ab409d8b
https://doi.org/10.1021/acsmedchemlett.1c00450
https://doi.org/10.1021/acsmedchemlett.1c00450
Autor:
Mari Manuia, Wenshuo Lu, Laura J. Kingsley, Zhiwei Ma, Vicki Zhou, Darbi Witmer, Glen Spraggon, Mu-Yun Gao, Pierre-Yves Michellys, Min Lu, Yong Jia, Matthew McNeill, Sarah Greenblatt, Bender Steven Lee, Andreas Kreusch, Gerald Lelais, Xiaohui He, Victor Nikulin, Mei-Ting Vaillancourt, Christian C. Lee, Jacob R. Haling, John Nelson, Ajay A. Vashisht
Publikováno v:
Journal of Medicinal Chemistry. 64:4857-4869
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b50a3181ddf89b7c66263433d103701a
https://doi.org/10.1021/acs.jmedchem.0c02152
https://doi.org/10.1021/acs.jmedchem.0c02152
Autor:
Glen Spraggon, Smith Jeffrey M, Chianelli Donatella, Advait Nagle, Christian Wiesmann, Xiaodong Liu, Yongping Xie, Richard J. Sciotti, Todd Groessl, Kevin Johnson, Xianzhong Liu, Celine Be, Christopher Thompson, Yin H. Lai, Jan Jiricek, Patrick J Rudewicz, Brandon S. Pybus, Casey J. N. Mathison, Valentina Molteni, Honnappa Srinivas, Richard Glynne, Jaime Ballard, Agnes Biggart, Diana Caridha, Andreas Hein, Ashley Mitchell Berman, Mu-Yun Gao, Lauren C. Davis, Michael Shapiro, Michael Gibney, Yen Liang Chen, Vince Yeh, Fabian K. Eggimann, Badry Bursulaya, Mara Kreishman-Deitrick, Lerario Isabelle K, Fang Liang, Shilpi Khare, Wendy Richmond, Srinivasa P. S. Rao, Frantisek Supek, Tove Tuntland, Alexandre Luneau
Publikováno v:
Journal of Medicinal Chemistry
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37584f6654d3dc34b0710ef1ed444634
https://doi.org/10.1021/acs.jmedchem.0c00499
https://doi.org/10.1021/acs.jmedchem.0c00499
Autor:
Badry Bursulaya, Nanxin Li, Yang Yang, Chianelli Donatella, John Nelson, Casey J. N. Mathison, Valentina Molteni, Sergio Briones, Chun Li, Shailaja Kasibhatla, Christian C. Lee, Jason Roland, Zhihong Huang, Jiqing Jiang, Anna Galkin, John Tellew, Robert Epple, Jacqueline Kinyamu-Akunda, Yelena Sarkisova, Mu-Yun Gao, Rie Kikkawa, Lintong Li, Su Hua, Paul Vincent Rucker, Jennifer Shaffer, Yun Feng Xie
Publikováno v:
ACS Medicinal Chemistry Letters. 11:558-565
RET (REarranged during Transfection) kinase gain-of-function aberrancies have been identified as potential oncogenic drivers in lung adenocarcinoma, along with several other cancer types, prompting the discovery and assessment of selective inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c095921d2621bc9f442ce1c2e02b661
https://doi.org/10.1021/acsmedchemlett.0c00015
https://doi.org/10.1021/acsmedchemlett.0c00015
Autor:
Laura J, Kingsley, Xiaohui, He, Matthew, McNeill, John, Nelson, Victor, Nikulin, Zhiwei, Ma, Wenshuo, Lu, Vicki W, Zhou, Mari, Manuia, Andreas, Kreusch, Mu-Yun, Gao, Darbi, Witmer, Mei-Ting, Vaillancourt, Min, Lu, Sarah, Greenblatt, Christian, Lee, Ajay, Vashisht, Steven, Bender, Glen, Spraggon, Pierre-Yves, Michellys, Yong, Jia, Jacob R, Haling, Gérald, Lelais
Publikováno v:
Journal of medicinal chemistry. 64(8)
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e665e6a49bed89fff37af4eae908565f
https://pubmed.ncbi.nlm.nih.gov/33821636
https://pubmed.ncbi.nlm.nih.gov/33821636
Autor:
W. Perry Gordon, Tove Tuntland, Shelly Meeusen, Leah Clemmer, Sara Da Ros, Laura Bordone, Robert Hill, Thomas Hollenbeck, John W. Fathman, Kenneth Ng, Sheryll Espinola, Xiaohui He, Bo Liu, John Nelson, Maya Iskandar, Xue-Feng Zhu, Vân Nguyen-Tran, Andreas Kreusch, David C.S. Huang, Songchun Jiang, Yong Jia, Badry Bursulaya, Janine E. Baaten, Jian Shi, Mu-Yun Gao, Tao Jiang, Barun Okram, Glen Spraggon, Pierre-Yves Michellys, Hong Liu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1048-1053
NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of NOD2 pathway has been associated with a num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c03b4d7782a1105eb048003151bbcc2
https://doi.org/10.1021/acsmedchemlett.7b00258
https://doi.org/10.1021/acsmedchemlett.7b00258
Autor:
Advait Nagle, Ben G. Wen, Srinivasa P. S. Rao, Monique Stinson, Glenn C. Federe, Richard Glynne, Yin H. Lai, Ianne C. Rivera, Ansgar Brock, Michael Shapiro, Hazel X. Y. Koh, John D. Venable, Jaime Ballard, J. Robert Gillespie, Badry Bursulaya, Glen Spraggon, Xianzhong Liu, Mu-Yun Gao, Vince Yeh, Tove Tuntland, Fang Liang, S. Whitney Barnes, Todd Groessl, Shilpi Khare, Elmarie Myburgh, Agnes Biggart, Lauren C. Davis, Jocelyn Tan, Pranab Mishra, Frantisek Supek, Casey J. N. Mathison, Valentina Molteni, Jeremy C. Mottram, Frederick S. Buckner, John R. Walker
Publikováno v:
Nature
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually1. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania spp. and Trypano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bc027b1d63c94a64adf691d28ee40c
http://europepmc.org/articles/PMC5161665
http://europepmc.org/articles/PMC5161665
Autor:
Loren Miraglia, S. Whitney Barnes, Jennifer Snead, Carsten Russ, Peter McNamara, John Lamb, Albert E. Parker, Chris Trussell, J. Scott Lee, Orzala Sharif, Pamela Y. Ting, John R. Walker, Michael P. Cooke, Anthony E. Boitano, Scott Clarkson, Fabio Luna, Heath E. Klock, Julie Vance, Mu-Yun Gao, Christian Schmedt, Glenn C. Federe
Publikováno v:
Nature methods. 15(11)
CRISPR–Cas9 screening allows genome-wide interrogation of gene function. Currently, to achieve the high and uniform Cas9 expression desirable for screening, one needs to engineer stable and clonal Cas9-expressing cells—an approach that is not app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d6ea3f1ecc35af01d19e315b272f72
https://pubmed.ncbi.nlm.nih.gov/30297964
https://pubmed.ncbi.nlm.nih.gov/30297964
Autor:
Mu-Yun Gao, Kenneth Ng, Connie Chen, Jennifer L. Harris, Scott A. Lesley, Christian C. Lee, Nanxin Li, Xiuying Sun, Sungjoon Kim, Su Hua, Yong Jia, Eileen Ambing, Glen Spraggon, Pierre-Yves Michellys
Publikováno v:
Biochemical Journal. 430:425-437
ALK (anaplastic lymphoma kinase) is an RTK (receptor tyrosine kinase) of the IRK (insulin receptor kinase) superfamily, which share an YXXXYY autophosphorylation motif within their A-loops (activation loops). A common activation and regulatory mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5c0597ea87dd8f87c618116fbeb545
https://doi.org/10.1042/bj20100609
https://doi.org/10.1042/bj20100609
Autor:
Lennart S. Forsberg, Wim D'Haeze, Mu-Yun Gao, Russell W. Carlson, Graham C. Walker, Zhi-Ping Xie, Kathryn M. Jones, Wolfgang R. Streit, Brett J. Pellock, William J. Broughton, Christian Staehelin
Publikováno v:
Journal of Bacteriology. 188:6168-6178
Legumes establish mutualistic associations with nitrogen-fixing bacteria, commonly referred to as rhizobia. Most rhizobia enter roots of host plants via root hairs, where they induce the formation of infection threads. Bacterial invasion and formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f739c33d6557c327e7a089bbd37e6df0
https://doi.org/10.1128/jb.00365-06
https://doi.org/10.1128/jb.00365-06