Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Mu-Shui Dai"'
Autor:
Kewei Qin, Shuhan Yu, Yang Liu, Rongtian Guo, Shiya Guo, Junjie Fei, Yuemeng Wang, Kaiyuan Jia, Zhiqiang Xu, Hu Chen, Fengtian Li, Mengmeng Niu, Mu-Shui Dai, Lunzhi Dai, Yang Cao, Yujun Zhang, Zhi-Xiong Jim Xiao, Yong Yi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for t
Externí odkaz:
https://doaj.org/article/e870a2212b0b4d6ab060b6b47dd7a212
Autor:
Zinab O. Doha, Xiaoyan Wang, Nicholas L. Calistri, Jennifer Eng, Colin J. Daniel, Luke Ternes, Eun Na Kim, Carl Pelz, Michael Munks, Courtney Betts, Sunjong Kwon, Elmar Bucher, Xi Li, Trent Waugh, Zuzana Tatarova, Dylan Blumberg, Aaron Ko, Nell Kirchberger, Jennifer A. Pietenpol, Melinda E. Sanders, Ellen M. Langer, Mu-Shui Dai, Gordon Mills, Koei Chin, Young Hwan Chang, Lisa M. Coussens, Joe W. Gray, Laura M. Heiser, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop
Externí odkaz:
https://doaj.org/article/2f5efa1be7d149bcb492c236e0e02ed5
Publikováno v:
Genes and Diseases, Vol 6, Iss 4, Pp 359-371 (2019)
The transcription factor c-MYC (MYC thereafter) controls diverse transcription programs and plays a key role in the development of many human cancers. Cells develop multiple mechanisms to ensure that MYC levels and activity are precisely controlled i
Externí odkaz:
https://doaj.org/article/d6669fd820c14b4cb153f04f27c50b70
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Deregulated MYC overexpression and activation contributes to tumor growth and progression. Given the short half-life and unstable nature of the MYC protein, it is not surprising that the oncoprotein is highly regulated via diverse posttranslational m
Externí odkaz:
https://doaj.org/article/8759667beaa7481094927639c970f2e7
Autor:
Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai
Publikováno v:
Nucleic Acids Research. 51:3934-3949
The RNA exosome is an essential 3′ to 5′ exoribonuclease complex that mediates degradation, processing and quality control of virtually all eukaryotic RNAs. The nucleolar RNA exosome, consisting of a nine-subunit core and a distributive 3′ to 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27d1f3921e97d4ae33c8cb193c79d70f
https://doi.org/10.1093/nar/gkad140
https://doi.org/10.1093/nar/gkad140
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a c
Externí odkaz:
https://doaj.org/article/a8005aaa196741b4875ef154e15dfa76
Autor:
Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap, David Z. Qian
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (
Externí odkaz:
https://doaj.org/article/0252ed6647884c3d9a7e3a856e52ca42
Supplementary Fig. S4 shows the effects of USP36 on DGCR8 ubiquitination and that USP36 SUMOylation of DGCR8 does not depend on its DUB activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5306862ea73698df1da67d523e30f988
https://doi.org/10.1158/2767-9764.22546735.v1
https://doi.org/10.1158/2767-9764.22546735.v1
miRNA biogenesis is a cellular process that produces mature miRNAs from their primary transcripts, pri-miRNAs, via two RNAse III enzyme complexes: the Drosha-DGCR8 microprocessor complex in the nucleus and the Dicer-TRBP complex in the cytoplasm. Eme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d54c7441815a072d2257f9188772e
https://doi.org/10.1158/2767-9764.c.6551239
https://doi.org/10.1158/2767-9764.c.6551239
Autor:
Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap, David Z. Qian
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained errors in Fig. 7. In panels e and f, the graph titles incorrectly read ‘LNCaP-AdtNs’ and ‘LAPC4-AdtNs’, respectively. These errors have now been corrected in both the PDF and HTML versions of the
Externí odkaz:
https://doaj.org/article/7f5752955e824d958111bde601943bb7