Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mu Tsu Wu"'
Autor:
Sharon Sadowski, William J. Greenlee, Catherine D. Strader, Sander G. Mills, Margaret A. Cascieri, Richard J. Budhu, Mu Tsu Wu, Conrad P. Dorn, Malcolm MacCoss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2707-2712
A series of N,N′-diacylpiperazine-2-carboxamides are shown to be antagonists of the NK-1 (Substance P) receptor. Elaboration of the C2 sidechain with aminoalkyl groups leads to two series of potent antagonists, one containing simple dialkylamino gr
Autor:
Raymond S.L. Chang, Victor J. Lotti, T.J. Ikeler, William J. Greenlee, Mu Tsu Wu, Wallace T. Ashton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2023-2028
A novel series of 1,4-disubstituted-piperazine-2-carboxylic acids has been discovered as AT2-selective non-peptide angiotensin II receptor antagonists with nanomolar or subnanomolar potency. L-159,686 [(S)-1,4-bis(N,N-diphenylcarbamoyl)piperazine-2-c
Publikováno v:
ChemInform. 22
Publikováno v:
Journal of Heterocyclic Chemistry. 27:1559-1563
Tricyclic analogs of piperazinylthiopyrano[3,2-d]pyrimidine hypoglycemic agents were prepared. The angular tricyclic systems, 8,9-dihydro-7H-thiopyrano[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine and 8,9-dihydro-7H-tetrazolo[1,5-a]thiopyrano[2,3-e]pyrimid
Publikováno v:
Tetrahedron Letters. 17:2405-2408
Autor:
D. L. Ondeyka, T.J. Ikeler, Henry Joshua, Alan W. Douglas, Arthur A. Patchett, Mu Tsu Wu, L.G. Payne
Publikováno v:
Journal of Pharmaceutical Sciences. 74:352-354
The synthesis and some of the spectral properties of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril, MK-521) are described. This compound inhibits angiotensin-converting enzyme with an IC50 of 1.2 X 10(-9) M.
Autor:
Norman Doorenbos, Mu Tsu Wu
Publikováno v:
The Journal of Organic Chemistry. 26:4550-4552
Autor:
Norman J. Doorenbos, Mu Tsu Wu
Publikováno v:
Journal of Pharmaceutical Sciences. 54:1290-1292
3,5-Seco-4-norcholestan-5-on-3-oic acid reacts with 1,3-diaminopropane and ethylenediamine at reflux temperatures to yield 1′,4′,5′,6′-tetrahydropyrimidino-[ a -4,3]-4 -aza-5-cholestene (III) and 2′,3′-dihydroimidazolino[ a -4,3]-4-aza-5-
Publikováno v:
Chemischer Informationsdienst. 11
Autor:
Alan L. Maycock, Linda G. Payne, Broeke Jan Ten, Donna M. DeSousa, Mu Tsu Wu, Arthur A. Patchett
Publikováno v:
Biochemical and biophysical research communications. 102(3)
A design principle effective for generating inhibitors of angiotensin converting enzyme has been successfully extended to inhibitors of another Zn ++ endopeptidase, thermolysin. Hence, N-(1-carboxy-3-phenylpropyl)LeuTrp is found to be a potent inhibi