Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mu Sen Liu"'
Autor:
Zachary A. Gurard-Levin, Brian McMillan, Douglas A. Whittington, Brian Doyon, Michael D. Scholle, Jacques Ermolieff, Madhavi Bandi, Mu-Sen Liu, Alvaro Amor, William D. Mallender
Publikováno v:
SLAS Technology, Vol 29, Iss 5, Pp 100173- (2024)
Polymerase β (POLB), with dual functionality as a lyase and polymerase, plays a critical role in the base excision repair (BER) pathway to maintain genomic stability. POLB knockout and rescue studies in BRCA1/2-mutant cancer cell lines revealed that
Externí odkaz:
https://doaj.org/article/2814a1a1f9b140339aad8d4a13a4a653
Autor:
Mu-Sen Liu, Shanzhong Gong, Helen-Hong Yu, Kyungseok Jung, Kenneth A. Johnson, David W. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Engineered high-fidelity Cas9s have increased discrimination against off-targets. Kinetic analyses of Cas9-HF1 and HypaCas9 engineered Cas9 variants show that their DNA cleavage is impaired by more than 100- fold, which leads to release rather than c
Externí odkaz:
https://doaj.org/article/eaec27d1773d4739aca435216526ab4f
Autor:
Jack P. K. Bravo, Mu-Sen Liu, Grace N. Hibshman, Tyler L. Dangerfield, Kyungseok Jung, Ryan S. McCool, Kenneth A. Johnson, David W. Taylor
Publikováno v:
Nature. 603:343-347
CRISPR–Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage1–4, and the underlying mechanisms by which Cas9 recognizes mismatches are poorly understood5–7. Although Cas9 variants with greater discrimination against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::984fc4cf77a551b3116aa60d4788ab46
https://doi.org/10.1038/s41586-022-04470-1
https://doi.org/10.1038/s41586-022-04470-1
Autor:
Mu-Sen Liu, Ryan S McCool, Kyungseok Jung, David W. Taylor, Jack P.K. Bravo, Kenneth A. Johnson
The widespread use of CRISPR/Cas9 as a programmable genome editing tool has been hindered by off-target DNA cleavage (Cong et al., 2013; Doudna, 2020; Fu et al., 2013; Jinek et al., 2013). While analysis of such off-target editing events have enabled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296395cb585f9b2288fb1735d196ce37
https://doi.org/10.1101/2021.09.14.460224
https://doi.org/10.1101/2021.09.14.460224
Autor:
Jack P K, Bravo, Mu-Sen, Liu, Grace N, Hibshman, Tyler L, Dangerfield, Kyungseok, Jung, Ryan S, McCool, Kenneth A, Johnson, David W, Taylor
Publikováno v:
Nature. 603(7900)
CRISPR-Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5140ff34a4dfaefea14087abd0a9ece0
https://pubmed.ncbi.nlm.nih.gov/35927241
https://pubmed.ncbi.nlm.nih.gov/35927241
Autor:
Jack P. K. Bravo, Mu-Sen Liu, Grace N. Hibshman, Tyler L. Dangerfield, Kyungseok Jung, Ryan S. McCool, Kenneth A. Johnson, David W. Taylor
Publikováno v:
Nature. 604:E10-E10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36da55480d164556ef9ee166fb4f09d5
https://doi.org/10.1038/s41586-022-04655-8
https://doi.org/10.1038/s41586-022-04655-8
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c85be95bdc86cf3ff2f2b66b78334b36
https://doi.org/10.1096/fasebj.2019.33.1_supplement.620.4
https://doi.org/10.1096/fasebj.2019.33.1_supplement.620.4
Publikováno v:
Methods Enzymol
Bacterial adaptive immune systems employ clustered regularly interspaced short palindromic repeats (CRISPR) along with their CRISPR-associated genes (Cas) to form CRISPR RNA (crRNA)-guided surveillance complexes, which target foreign nucleic acids fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752084268fbd5ec592a8571dccb99a43
https://europepmc.org/articles/PMC8364395/
https://europepmc.org/articles/PMC8364395/
Publikováno v:
Scientific Reports
Methyltransferases play crucial roles in many cellular processes, and various regulatory mechanisms have evolved to control their activities. For methyltransferases involved in biosynthetic pathways, regulation via feedback inhibition is a commonly e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edd899a449e827e855701b4271f8d6a
https://doi.org/10.1038/srep38071
https://doi.org/10.1038/srep38071
Publikováno v:
Journal of the American Chemical Society. 138(7)
The mechanism of DNA polymerase (pol) fidelity is of fundamental importance in chemistry and biology. While high-fidelity pols have been well studied, much less is known about how some pols achieve medium or low fidelity with functional importance. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47e40aac9c67d2be478a5d564c244fd
https://pubmed.ncbi.nlm.nih.gov/26836966
https://pubmed.ncbi.nlm.nih.gov/26836966