Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mu Fa Zou"'
Autor:
Ben D. Richardson, Kaustuv Saha, Danielle Krout, Elizabeth Cabrera, Bruce Felts, L. Keith Henry, Jarod Swant, Mu-Fa Zou, Amy Hauck Newman, Habibeh Khoshbouei
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The dopaminergic system has important roles in a number of cognitive process. Here, the authors use detailed analysis of dopamine transporter trafficking to show its levels at the cell surface are sensitive to changes in membrane potential.
Externí odkaz:
https://doaj.org/article/6f106f3acb6d481bbed0b3a48bcfa7a6
Autor:
Danielle Krout, Akula Bala Pramod, Michael J. Tomlinson, James D. Foster, Rejwi Acharya Dahal, Mu Fa Zou, John R. Lever, L. Keith Henry, Comfort Boatang, Roxanne A. Vaughan, Amy Hauck Newman, Babita Sharma
Publikováno v:
Biochem Pharmacol
Dopamine transporter (DAT) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (DA). The resulting increases in DA lead to the ability
Autor:
Alessandro, Bonifazi, Hideaki, Yano, Michael P, Ellenberger, Ludovic, Muller, Vivek, Kumar, Mu-Fa, Zou, Ning Sheng, Cai, Adrian M, Guerrero, Amina S, Woods, Lei, Shi, Amy Hauck, Newman
Publikováno v:
J Med Chem
The development of bivalent ligands has attracted interest as a way to potentially improve the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct receptor binding sites simultaneously can allow the selective
Autor:
Weimin Conrad Hong, Amy Hauck Newman, Jonathan L. Katz, Paul L. Soto, Mu-Fa Zou, Theresa A. Kopajtic, Derek S. Wilkinson, Takato Hiranita, Carl R. Lupica
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:297-309
The present study examined RTI-371 [3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)-isoxazol-5-yl]tropane], a phenyltropane cocaine analog with effects distinct from cocaine, and assessed potential mechanisms for those effects by comparison with its con
Autor:
Amy Hauck Newman, Hong Ju Yang, Hai Ying Zhang, Xiao-Fei Wang, Zheng-Xiong Xi, Eliot L. Gardner, Guo Hua Bi, Thomas M. Keck, Ratika Srivastava, Mu Fa Zou
Publikováno v:
Addiction Biology. 19:195-209
Preclinical studies suggest that negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5), including MPEP (2-methyl-6-(phenylethynyl)pyridine), MTEP (3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine) and fenobam,
Autor:
Prashant Donthamsetti, Caitlin Burzynski, Mu Fa Zou, Jonathan A. Javitch, Alessandro Bonifazi, Vivek Kumar, Catherine Schweppe, Mayako Michino, R. Benjamin Free, Aaron Janowsky, Lei Shi, David R. Sibley, Amy Hauck Newman, Thomas M. Keck
Publikováno v:
Journal of Medicinal Chemistry
Novel 1-, 5-, and 8-substituted analogues of sumanirole (1), a dopamine D2/D3 receptor (D2R/D3R) agonist, were synthesized. Binding affinities at both D2R and D3R were higher when determined in competition with the agonist radioligand [(3)H]7-hydroxy
Autor:
Mu-Fa Zou, Jarod Swant, Danielle Krout, Bruce Felts, Elizabeth Cabrera, L. Keith Henry, Habibeh Khoshbouei, Amy Hauck Newman, Kaustuv Saha, Ben Richardson
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The dopaminergic system is essential for cognitive processes, including reward, attention and motor control. In addition to DA release and availability of synaptic DA receptors, timing and magnitude of DA neurotransmission depend on extracellular DA-
Autor:
Hermann J. Gruber, Christian Rankl, Rong Zhu, Michael Freissmuth, Peter Hinterdorfer, Thomas Haselgrübler, Mu-Fa Zou, Linda Wildling, Marion Holy, Amy Hauck Newman, Harald H. Sitte
Publikováno v:
The Journal of Biological Chemistry
Background: The serotonin transporter is the site of action of antidepressants and amphetamines. Results: Single molecular force spectroscopy allowed for mapping the energy landscape involved in MFZ2-12/SERT binding. Conclusion: Our data indicate tha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2650-2654
Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amide-based positive allosteric modulators, optimized substitution of the aryl 'b' ring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benz
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:3026-3035
The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGlu