PSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study

Autor: Esther San Antonio, Javier Silván, Javier Sevilla-Montero, Elena González-Sánchez, Antonio Muñoz-Callejas, Inés Sánchez-Abad, Alejandra Ramos-Manzano, Cecilia Muñoz-Calleja, Isidoro González-Álvaro, Eva G. Tomero, Javier García-Pérez, Rosario García-Vicuña, Esther F. Vicente-Rabaneda, Santos Castañeda, Ana Urzainqui

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundEarly diagnosis and treatment of Systemic lupus erythematosus (SLE) and Systemic sclerosis (SSc) present significant challenges for clinicians. Although various studies have observed changes in serum levels of selectins between healthy dono

Externí odkaz: https://doaj.org/article/5783aa89857f464c8a98c268bfa965dc

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Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma-related interstitial lung disease developed by PSGL-1 deficient mice.

Autor: González‐Sánchez, Elena¹ (AUTHOR), Muñoz‐Callejas, Antonio¹ (AUTHOR), Gómez‐Román, Javier² (AUTHOR), San Antonio, Esther¹ (AUTHOR), Marengo, Alessandro³ (AUTHOR), Tsapis, Nicolas³ (AUTHOR), Bohne‐Japiassu, Kamila³ (AUTHOR), González‐Tajuelo, Rafael¹ (AUTHOR), Pereda, Saray² (AUTHOR), García‐Pérez, Javier⁴ (AUTHOR), Cavagna, Lorenzo⁵ (AUTHOR), González‐Gay, Miguel Ángel⁶ (AUTHOR), Vicente‐Rabaneda, Esther Francisca⁷ (AUTHOR), Meloni, Federica⁸ (AUTHOR), Fattal, Elias³ (AUTHOR), Castañeda, Santos^7,9 (AUTHOR) scastas@gmail.com, Urzainqui, Ana¹ (AUTHOR) urzainquimayayo@gmail.com, González-Sánchez, Elena¹⁰ (AUTHOR), Muñoz-Callejas, Antonio¹⁰ (AUTHOR), Gómez-Román, Javier² (AUTHOR)

Publikováno v: British Journal of Pharmacology. Sep2022, Vol. 179 Issue 18, p4534-4548. 15p. 3 Color Photographs, 4 Graphs.

IGF-1 facilitates extinction of conditioned fear

Autor: Laura E Maglio, José A Noriega-Prieto, Irene B Maroto, Jesús Martin-Cortecero, Antonio Muñoz-Callejas, Marta Callejo-Móstoles, David Fernández de Sevilla

Publikováno v: eLife, Vol 10 (2021)

Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing and synaptic transmission in many areas of the central nervous system, its si

Externí odkaz: https://doaj.org/article/4f62044224414736b4d2eefc48745254

Relevance of PSGL-1 Expression in B Cell Development and Activation

Autor: Rafael González-Tajuelo, Elena González-Sánchez, Javier Silván, Antonio Muñoz-Callejas, Esther Vicente-Rabaneda, Javier García-Pérez, Santos Castañeda, Ana Urzainqui

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

PSGL-1 is expressed in all plasma cells, but only in a small percentage of circulating B cells. Patients with systemic sclerosis (SSc) show reduced expression of PSGL-1 in B cells and increased prevalence of pulmonary arterial hypertension. PSGL-1 de

Externí odkaz: https://doaj.org/article/10dec0b69e4d49959501ce2fe763bc9f