Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Muñoz Torrero, D. ."'
Autor:
Sola, I., Artigas, A., Taylor, M.C., Perez-Areales, F.J., Viayna, E., Clos, M.V., Perez, B., Wright, Colin W., Kelly, J.M., Muñoz-Torrero, D.
Yes
Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently
Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently
Externí odkaz:
http://hdl.handle.net/10454/8940
Autor:
Sola, I., Castellà, S., Viayna, E., Galdeano, C., Taylor, M.C., Gbedema, Stephen Y., Pérez, B., Clos, M.V., Jones, D.C., Fairlamb, A.H., Wright, Colin W., Kelly, J.M., Muñoz-Torrero, D.
Yes
Dual submicromolar trypanocidal–antiplasmodial compounds have been identified by screening and chemical synthesis of 4-aminoquinoline-based heterodimeric compounds of three different structural classes. In Trypanosoma brucei, inhibition of
Dual submicromolar trypanocidal–antiplasmodial compounds have been identified by screening and chemical synthesis of 4-aminoquinoline-based heterodimeric compounds of three different structural classes. In Trypanosoma brucei, inhibition of
Externí odkaz:
http://hdl.handle.net/10454/7485
Autor:
Sola, I., Artigas, A., Taylor, M.C., Gbedema, Stephen Y., Perez, B., Clos, M.V., Wright, Colin W., Kelly, J.M., Muñoz-Torrero, D.
We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability. Most dimers h
Externí odkaz:
http://hdl.handle.net/10454/7496
Akademický článek
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Autor:
Defaux, J., Sala, M., Formosa, X., Galdeano, C., Taylor, M.C., Kelly, J.M., Wright, Colin W., Camps, P., Muñoz-Torrero, D., Alobaid, Waleed A.A.
A series of 19 huprines has been evaluated for their activity against cultured bloodstream forms of Trypanosoma brucei and Plasmodium falciparum. Moreover, cytotoxicity against rat myoblast L6 cells was assessed for selected huprines. All the tested
Externí odkaz:
http://hdl.handle.net/10454/7468
Autor:
Oluwafemi, A.J., Okanla, O., Camps, P., Muñoz-Torrero, D., Mackey, Z.B., Chiang, P.K., Seville, Scott, Wright, Colin W.
The alkaloid cryptolepine (1) and eight synthetic analogues (2-8) were assessed for in vitro activities against Trypanosoma brucei. Four of the analogues were found to be highly potent with IC50 values of less than 3 nM and three of these were assess
Externí odkaz:
http://hdl.handle.net/10454/4534
Akademický článek
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