Drug resistance profiling of asymptomatic and low-density Plasmodium falciparum malaria infections on Ngodhe island, Kenya, using custom dual-indexing next-generation sequencing

Autor: Ashley Osborne, Jody E. Phelan, Akira Kaneko, Wataru Kagaya, Chim Chan, Mtakai Ngara, James Kongere, Kiyoshi Kita, Jesse Gitaka, Susana Campino, Taane G. Clark

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Malaria control initiatives require rapid and reliable methods for the detection and monitoring of molecular markers associated with antimalarial drug resistance in Plasmodium falciparum parasites. Ngodhe island, Kenya, presents a unique mal

Externí odkaz: https://doaj.org/article/66339eca5adf4207b3bef237ef38de6b

Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial

Autor: Wataru Kagaya, Chim W. Chan, James Kongere, Bernard N. Kanoi, Mtakai Ngara, Protus Omondi, Ashley Osborne, Laura Barbieri, Achyut Kc, Noboru Minakawa, Jesse Gitaka, Akira Kaneko

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-14 (2023)

Abstract Background In the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is ha

Externí odkaz: https://doaj.org/article/fb9931046d364897bbfa438be1b99667

Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya

Autor: Ashley Osborne, Emilia Manko, Mika Takeda, Akira Kaneko, Wataru Kagaya, Chim Chan, Mtakai Ngara, James Kongere, Kiyoshi Kita, Susana Campino, Osamu Kaneko, Jesse Gitaka, Taane G. Clark

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Characterising the genomic variation and population dynamics of Plasmodium falciparum parasites in high transmission regions of Sub-Saharan Africa is crucial to the long-term efficacy of regional malaria elimination campaigns and eradication

Externí odkaz: https://doaj.org/article/d5c85ce9fdaf49dba64b728e4709019d

Lessons from single-cell RNA sequencing of human islets

Autor: Mtakai Ngara, Nils Wierup

Publikováno v: Diabetologia. 65(8)

Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13df2b641b5f5125962943fe95f72b4a
https://pubmed.ncbi.nlm.nih.gov/35482056

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Autor: Peter Hokland, Luca Malcovati, Teresa Mortera-Blanco, Paresh Vyas, Mohsen Karimi, Magnus Tobiasson, Lennart Nilsson, Stefan N. Constantinescu, Rikard Erlandsson, John E. Pimanda, Helen Doolittle, Stephen Taylor, Mtakai Ngara, Laura Stenson, Supat Thongjuea, Pierre Fenaux, Onima Chowdhury, Claus Nerlov, David C. Wedge, Peter J. Campbell, Elli Papaemmanuil, Sten Linnarsson, Christian Scharenberg, Dag Josefsen, Andrea Pellagatti, Eva Hellström-Lindberg, Gudrun Göhring, Eleni Giannoulatou, Sten Eirik W. Jacobsen, Qiaolin Deng, Brigitte Schlegelberger, Kristina Anderson, David G. Bowen, Mario Cazzola, Sally Ann Clark, Iain C. Macaulay, Gunnar Kvalheim, Sara Duarte, Adam J. Mead, Sudhir Tauro, Jacqueline Boultwood, Alice Giustacchini, Ingunn Dybedal, Una Kjällquist, Petter S. Woll, Ashwin Unnikrishnan, Mette Holm, Rickard Sandberg

Publikováno v: Woll, P S, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D C, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A J, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I C, Clark, S A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, M S, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J E, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, S N, Nerlov, C, Nilsson, L, Campbell, P J, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S & Jacobsen, S E W 2014, ' Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo ', Cancer Cell, vol. 25, no. 6, pp. 794-808 . https://doi.org/10.1016/j.ccr.2014.03.036

Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which differentcancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052834e561f5970d9c35830b2bcf9d78
https://doi.org/10.1016/j.ccr.2014.03.036