Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mrutyunjaya Parida"'
Autor:
Benjamin M. Spector, Mrutyunjaya Parida, Ming Li, Christopher B. Ball, Jeffery L. Meier, Donal S. Luse, David H. Price
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors digested chromatin with DNA fragmentation factor (DFF) prior to chromatin immunoprecipitation (DFF-ChIP) to depict transcription complex interactions with neighboring nucleosomes in cells. Applying this method to human cytomegaloviru
Externí odkaz:
https://doaj.org/article/33f9d6cf78be4231a55f0cb8c89e9986
Autor:
Christopher B. Ball, Ming Li, Mrutyunjaya Parida, Qiaolin Hu, Deniz Ince, Geoffrey S. Collins, Jeffery L. Meier, David H. Price
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional transcription factor that is essential for lytic HCMV infection. IE2 functions as an activator of viral early genes, negatively regulates its own promoter, and
Externí odkaz:
https://doaj.org/article/10a5beb994ac4f109410dd7938ac7a27
Autor:
Stacey L. Peek, Peter J. Bosch, Ethan Bahl, Brianna J. Iverson, Mrutyunjaya Parida, Preeti Bais, J. Robert Manak, Jacob J. Michaelson, Robert W. Burgess, Joshua A. Weiner
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103814- (2022)
Summary: Proper gene regulation is critical for both neuronal development and maintenance as the brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that interacts with transcription factors and chromatin remodeling c
Externí odkaz:
https://doaj.org/article/940e5ca7dbf344f6b80be4c28e562945
Autor:
Ming Li, Qiaolin Hu, Geoffrey Collins, Mrutyunjaya Parida, Christopher B Ball, David H Price, Jeffery L Meier
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009796 (2021)
Beta- and gammaherpesviruses late transcription factors (LTFs) target viral promoters containing a TATT sequence to drive transcription after viral DNA replication has begun. Human cytomegalovirus (HCMV), a betaherpesvirus, uses the UL87 LTF to bind
Externí odkaz:
https://doaj.org/article/225d627470554592af8395fc6114df95
Autor:
Christopher B. Ball, Mrutyunjaya Parida, Ming Li, Benjamin M. Spector, Gustavo A. Suarez, Jeffery L. Meier, David H. Price
Publikováno v:
Viruses, Vol 14, Iss 4, p 779 (2022)
How human cytomegalovirus (HCMV) infection impacts the transcription of the host genome remains incompletely understood. Here, we examine the global consequences of infection of primary human foreskin fibroblasts (HFFs) on transcription by RNA polyme
Externí odkaz:
https://doaj.org/article/32ecf6653ec44589a1a502beed585ca2
Autor:
Juan F. Santana, Mrutyunjaya Parida, Abby Long, Joshua Wankum, Anthony J. Lilienthal, Krishna M. Nukala, J. Robert Manak
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3218-3228.e5 (2020)
Summary: Drosophila Myb (Dm-Myb) encodes a protein that plays a key role in regulation of mitotic phase genes. Here, we further refine its role in the context of a developing tissue as a potentiator of gene expression required for proper RNA polymera
Externí odkaz:
https://doaj.org/article/5df3192e221c40ab9fda468c4bcfe991
Autor:
Catherina T. Pinnaro, Travis Henry, Heather J. Major, Mrutyunjaya Parida, Lucy E. DesJardin, John R. Manak, Benjamin W. Darbro
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Background The 22q11.2 deletion syndrome (22q11.2DS) is the most common contiguous microdeletion affecting humans and exhibits extreme phenotypic heterogeneity. Patients can manifest any combination of comorbidities including congenital hear
Externí odkaz:
https://doaj.org/article/6abb37a2a9404125b323502b3f811636
Autor:
Mrutyunjaya Parida, Kyle A. Nilson, Ming Li, Christopher B. Ball, Harrison A. Fuchs, Christine K. Lawson, Donal S. Luse, Jeffery L. Meier, David H. Price
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT The large genome of human cytomegalovirus (HCMV) is transcribed by RNA polymerase II (Pol II). However, it is not known how closely this betaherpesvirus follows host transcriptional paradigms. We applied PRO-Seq and PRO-Cap methods to profil
Externí odkaz:
https://doaj.org/article/a5da4a0ae2b2409fbf8c0b9a8da26b4e
Autor:
Christopher B Ball, Mrutyunjaya Parida, Juan F Santana, Benjamin M Spector, Gustavo A Suarez, David H Price
Publikováno v:
Nucleic Acids Research. 50:1908-1926
Approximately half of purified mammalian RNA polymerase II (Pol II) is associated with a tightly interacting sub-stoichiometric subunit, Gdown1. Previous studies have established that Gdown1 inhibits transcription initiation through competitive inter
While copy number variants (CNVs) have been identified as an important cause of rare genetic disorders, they have also been identified in unaffected control populations, making clinical interpretation of these lesions challenging. Discriminating beni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97468729b8b02a0e3c1d82d010290b13
https://doi.org/10.1101/2022.10.17.22280252
https://doi.org/10.1101/2022.10.17.22280252