Divergent Synthesis of Novel 3(5)-Aminoazole-Benzopyrone Hybrids and their Evaluation as α-Glucosidase Inhibitors.

Autor: Myshko AS; V P Kukhar IBOPC of the NAS of Ukraine, Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, Academika Kukharya Str. 1, 02094, Kyiv, UKRAINE., Mrug GP; V P Kukhar IBOPC of the NAS of Ukraine, Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, Kyiv, UKRAINE., Bondarenko SP; National University of Food Technologies, Department of Food Chemistr, Kyiv, UKRAINE., Demydchuk BA; V P Kukhar IBOPC of the NAS of Ukraine, Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, Kyiv, UKRAINE., Kobzar OL; V P Kukhar IBOPC of the NAS of Ukraine, Department of Bioorganic Mechanisms, UKRAINE., Buldenko VM; V P Kukhar IBOPC of the NAS of Ukraine, Department of Bioorganic Mechanisms, UKRAINE., Vovk AI; V P Kukhar IBOPC of the NAS of Ukraine, Department of Bioorganic Mechanisms, UKRAINE., Frasinyuk M; V P Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences: Institut bioorganicnoi himii ta naftohimii Nacional'na akademia nauk Ukraini, Department of chemistry of bioactive nitrogen containing heterocyclic bases, 1, Akademika Kukharia, 02094, Kyiv, UKRAINE.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Nov 19, pp. e202400525. Date of Electronic Publication: 2024 Nov 19.

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.

Autor: Tang B; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Frasinyuk MS; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv 02094, Ukraine.; National University of Food Technologies, Kyiv 01601, Ukraine., Chikwana VM; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Mahalingan KK; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Morgan CA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Segvich DM; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Bondarenko SP; National University of Food Technologies, Kyiv 01601, Ukraine., Mrug GP; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv 02094, Ukraine.; National University of Food Technologies, Kyiv 01601, Ukraine., Wyrebek P; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington 40506, Kentucky, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington 40536, Kentucky, United States., Watt DS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington 40506, Kentucky, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington 40536, Kentucky, United States.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington 40536, Kentucky, United States., DePaoli-Roach AA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Roach PJ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States., Hurley TD; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, Indiana, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3538-3551. Date of Electronic Publication: 2020 Mar 23.

Antineoplastic Isoflavonoids Derived from Intermediate ortho-Quinone Methides Generated from Mannich Bases.

Autor: Frasinyuk MS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0596, USA. mykhaylo.frasinyuk@ukr.net.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0509, USA. mykhaylo.frasinyuk@ukr.net.; Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv, 02094, Ukraine. mykhaylo.frasinyuk@ukr.net., Mrug GP; Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv, 02094, Ukraine., Bondarenko SP; Department of Chemistry, Taras Shevchenko Kyiv National University, Kyiv, 01601, Ukraine., Khilya VP; Department of Chemistry, Taras Shevchenko Kyiv National University, Kyiv, 01601, Ukraine., Sviripa VM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0596, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0509, USA., Syrotchuk OA; Central Laboratory for Quality Control of Medicines and Medical Products, Kyiv, 04053, Ukraine., Zhang W; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0596, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Cai X; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0596, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Fiandalo MV; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA., Mohler JL; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA., Liu C; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0596, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0596, USA. dwatt@uky.edu.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0509, USA. dwatt@uky.edu.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA. dwatt@uky.edu.

Publikováno v: ChemMedChem [ChemMedChem] 2016 Mar 17; Vol. 11 (6), pp. 600-11. Date of Electronic Publication: 2016 Feb 17.