Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mrudula Donepudi"'
Autor:
J. Aggarwal, M. Martin, T. Goss, Zobair M. Younossi, Martha S. Bayliss, Mrudula Donepudi, Montserrat Vera-Llonch
Publikováno v:
Alimentary Pharmacology & Therapeutics. 38:124-133
Summary Background Chronic hepatitis C virus (HCV) infection and its treatment impact patients' health-related quality of life (HRQL). Aim To report on treatment impact and predictors of HRQL among treatment-naive patients with genotype 1 chronic HCV
Autor:
Peer R. E. Mittl, Rajkumar Ganesan, Esther D. Lenherr, Franziska Frölich, Mrudula Donepudi, Heidi Roschitzki-Voser, Andreas Schweizer, Thilo Schroeder, Antonio Baici, Markus G. Grütter
Publikováno v:
Protein Expression and Purification; Vol 84
Protein expression and purification
Protein Expression and Purification
Protein expression and purification
Protein Expression and Purification
A number of strategies and protocols for the expression, purification and kinetic characterization of human caspases are described in the literature. We have systematically revised these protocols and present comprehensive optimized expression and pu
Autor:
Marilyn D. Resh, Mrudula Donepudi
Publikováno v:
Cellular Signalling. 20:1359-1367
c-Src is a non-receptor tyrosine kinase that associates with both the plasma membrane and endosomal compartments. In many human cancers, especially breast cancer, c-Src and the EGF receptor (EGFR) are overexpressed. Dual overexpression of c-Src and E
Publikováno v:
Molecular Cell. 11:543-549
In the death receptor induced apoptotic pathway, caspase-8 autocatalytically cleaves itself at specific cleavage sites. To better understand the regulatory mechanisms behind caspase-8 activation, we compared active wild-type caspase-8 (wtC8) and an u
Autor:
Markus G. Grütter, Mrudula Donepudi
Publikováno v:
Biophysical Chemistry. :145-153
Apoptosis is primarily executed by active caspases, which are derived from the inactive zymogens. Structural and biochemical studies of caspases-1, -3, -7, -8 and -9 have greatly enhanced our understanding of the structure, function, and specificity
Autor:
Markus Tschopp, Mrudula Donepudi, Joe C. Wu, Lalitha Kodandapani, Markus G. Grütter, Helen Blanchard
Publikováno v:
Journal of Molecular Biology. 302:9-16
Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target. Caspases are cysteine proteases that are specific for substrates with an aspartic acid residue at the P1 position an
Autor:
J. Aggarwal, Mrudula Donepudi, E. Suthoff, Montserrat Vera-Llonch, Zobair M. Younossi, T. Goss
Publikováno v:
Journal of viral hepatitis. 22(1)
Work productivity is impacted in hepatitis C virus (HCV)-infected patients and has been linked to treatment. In two Phase 3 trials, ADVANCE and ILLUMINATE, treatment-naive genotype 1 chronic HCV-infected patients received 12-week telaprevir (T) with
Autor:
M. Martin, Zobair M. Younossi, Thomas F. Goss, Montserrat Vera-Llonch, Mrudula Donepudi, Kenneth E. Sherman, Jyoti Aggarwal, Andrew J. Muir
Publikováno v:
American Journal of Gastroenterology. 107:S573-S574
Autor:
J. Aggarwal, Zobair M. Younossi, M. Martin, T. Goss, Montserrat Vera-Llonch, N. Hernandez, Mrudula Donepudi, Martha S. Bayliss
Publikováno v:
Journal of Hepatology. 56:S462-S463
Autor:
Jyoti Aggarwal, Stephen Bubb, Carly Dougher, Lauren Fusfeld, Montserrat Vera-Llonch, Mrudula Donepudi, Thomas F. Goss
Publikováno v:
BMC Infectious Diseases
Background Infection with hepatitis C virus (HCV) is associated with high morbidity and increased mortality but many patients avoid initiation of treatment or report challenges with treatment completion. The study objective was to identify motivators