Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mrudang M. Shah"'
Publikováno v:
ACS Chemical Neuroscience. 4:1382-1392
In this article, we have demonstrated the in vivo efficacy of D-512 and D-440 in a 6-OHDA-induced unilaterally lesioned rat model experiment, a Parkinson's disease animal model. D-512 is a novel highly potent D2/D3 agonist, and D-440 is a novel highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33125f8d635dc1d0d9af6c535cf5cc4
https://doi.org/10.1021/cn400106n
https://doi.org/10.1021/cn400106n
Publikováno v:
Inhalation Toxicology. 25:21-28
Adult Sprague-Dawley (SD) male rats were exposed for a single 3 h period to air, ozone (O₃) or O₃) followed by tobacco smoke (O₃/TS). For pulmonary effects, bronchoalveolar lavage (BAL) cells and fluid were analyzed. Data revealed a significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f877a3b354900f61b83432d50caf68
https://doi.org/10.3109/08958378.2012.751143
https://doi.org/10.3109/08958378.2012.751143
Autor:
Mrudang M. Shah, Catherine E. Sykes, Michael J. Kane, Denise I. Briggs, Mariana Angoa-Pérez, Dina M. Francescutti, Donald M. Kuhn, David R. Rosenberg, David M. Thomas
Publikováno v:
Journal of Neurochemistry. 121:974-984
Neuropsychiatric disorders characterized by behavioral disinhibition, including disorders of compulsivity (e.g. obsessive-compulsive disorder; OCD) and impulse-control (e.g. impulsive aggression), are severe, highly prevalent and chronically disablin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e44db78062ca7713d594f6fb5f3b5c
https://doi.org/10.1111/j.1471-4159.2012.07739.x
https://doi.org/10.1111/j.1471-4159.2012.07739.x
Autor:
Dina M. Francescutti-Verbeem, David M. Thomas, Donald M. Kuhn, Mrudang M. Shah, Mariana Angoa Pérez
Publikováno v:
Journal of Neurochemistry. 115:595-605
Methamphetamine (METH) is a neurotoxic drug of abuse that damages the dopamine (DA) neuronal system in a highly delimited manner. The brain structure most affected by METH is the striatum where long-term DA depletion and microglial activation are max
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c19bff962d8c4cab341c9e365cb12a9
https://doi.org/10.1111/j.1471-4159.2010.06950.x
https://doi.org/10.1111/j.1471-4159.2010.06950.x
Oxidative stress has been strongly implicated in the progression of Parkinson’s disease (PD). Depletion of cytoplasmic glutathione levels is one of the indications of oxidative stress, which occur in the substantia nigra of PD patients at an early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3183de75a044b0939047efede09831f6
https://europepmc.org/articles/PMC6158776/
https://europepmc.org/articles/PMC6158776/
Autor:
Sanjib Gogoi, Maarten E. A. Reith, Gyan Modi, Mrudang M. Shah, Aloke K. Dutta, Chandrashekhar Voshavar, Tamara Antonio
Publikováno v:
ACS chemical neuroscience. 5(8)
We have developed a series of dihydroxy compounds and related analogues based on our hybrid D2/D3 agonist molecular template to develop multifunctional drugs for symptomatic and neuroprotective treatment for Parkinson’s disease (PD). The lead compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96d47d3e7a579b44c03ce9850105a69
https://pubmed.ncbi.nlm.nih.gov/24960209
https://pubmed.ncbi.nlm.nih.gov/24960209
Psychostimulant methamphetamine (METH) is toxic to striatal dopaminergic and serotonergic nerve terminals in adult, but not in the adolescent, brain. Betulinic acid (BA) and its derivatives are promising anti-HIV agents with some toxic properties. Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d4f8abfe8d1a3229989d056943fecd
https://europepmc.org/articles/PMC4214679/
https://europepmc.org/articles/PMC4214679/
Autor:
Chandrashekhar Voshavar, Julie K. Andersen, Mrudang M. Shah, Liping Xu, Subramanian Rajagopalan, Aloke K. Dutta, Yevgeniya I. Shurubor, Flint Beal
Publikováno v:
Journal of neurochemistry. 131(1)
In this study, in vitro and in vivo experiments were carried out with the high-affinity multifunctional D2/D3 agonist D-512 in order to explore its potential neuroprotective effects in models of Parkinson’s disease (PD) and the potential mechanism(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bae97587b77767969b86b679aa71003
https://pubmed.ncbi.nlm.nih.gov/24848702
https://pubmed.ncbi.nlm.nih.gov/24848702
Autor:
David M. Thomas, Mrudang M. Shah, Matthew P. Galloway, Shane A. Perrine, Manuel Tancer, Teri Cichon, Brittney M. Cox
Adolescents and young adults disproportionately abuse 3,4-methylenedioxymethamphetamine (MDMA; ‘Ecstasy’); however, since most MDMA research has concentrated on adults, the effects of MDMA on the developing brain remain obscure. Therefore, we eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe393c71a281d420194072844d435655
https://europepmc.org/articles/PMC4348097/
https://europepmc.org/articles/PMC4348097/
Autor:
Michael J. Kane, Dina M. Francescutti, Catherine E. Sykes, Denise I. Briggs, Donald M. Kuhn, David M. Thomas, Mariana Angoa-Pérez, Mrudang M. Shah
Mephedrone (4-methylmethcathinone) is a β-ketoamphetamine stimulant drug of abuse with close structural and mechanistic similarities to methamphetamine. One of the most powerful actions associated with mephedrone is the ability to stimulate dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6bbdbb7b3ebb5d09472e06c8079707
https://europepmc.org/articles/PMC3604033/
https://europepmc.org/articles/PMC3604033/