Zobrazeno 1 - 10
of 683
pro vyhledávání: '"Mrtf"'
Autor:
Miriam Jasmin Franz, Pia Wenisch, Petra Wohlleben, Laura Rupprecht, Vladimir Chubanov, Thomas Gudermann, Salla Kyheröinen, Maria Kristina Vartiainen, Markus R. Heinrich, Susanne Muehlich
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200855- (2024)
Myocardin-related transcription factor A (MRTF-A) is a coactivator of serum response factor (SRF), which regulates the expression of genes involved in cell proliferation, migration, and differentiation and has been implicated in hepatocellular carcin
Externí odkaz:
https://doaj.org/article/274038273c614adea3c330d76567abe7
Autor:
Mandy M. Schofield, Alissa T. Rzepski, Stephanie Richardson-Solorzano, Jonah Hammerstedt, Sohan Shah, Chloe E. Mirack, Marin Herrick, Justin Parreno
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151424- (2024)
Actin is a central mediator of the chondrocyte phenotype. Monolayer expansion of articular chondrocytes on tissue culture polystyrene, for cell-based repair therapies, leads to chondrocyte dedifferentiation. During dedifferentiation, chondrocytes spr
Externí odkaz:
https://doaj.org/article/45e9bdf1b947473b916e009a3247ba49
Autor:
Ken’ichiro Hayashi, Reuben Jacob Labios, Tsuyoshi Morita, Atsushige Ashimori, Ren Aoki, Masanori Mikuni, Kazuhiro Kimura
Publikováno v:
Cell Structure and Function, Vol 48, Iss 2, Pp 199-210 (2023)
We have recently demonstrated that a LIM domain protein, cysteine and glycine-rich protein 2 (CSRP2 [CRP2]), plays a vital role in the functional expression of myofibroblasts and cancer-associated fibroblasts. CRP2 binds directly to myocardin-related
Externí odkaz:
https://doaj.org/article/41eff0a2a18f47b8a600c76b079db5f6
Akademický článek
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Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Highlights Formation of mammary acini depends on crosstalk between matrix stiffness and MRTF-A Increased matrix stiffness elevates MRTF-A activity and protrusion formation Protrusion formation of MCF10A-derived and primary murine acini is MRTF-depend
Externí odkaz:
https://doaj.org/article/bb3b020bfe6544e6a967a7b6f523424d
Akademický článek
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Publikováno v:
FASEB BioAdvances, Vol 4, Iss 8, Pp 509-523 (2022)
Abstract Breast cancer (BC)‐related mortality primarily results from metastatic colonization of disseminated cells. Actin polymerization plays an important role in driving post‐extravasation metastatic outgrowth of tumor cells. This study examine
Externí odkaz:
https://doaj.org/article/20555fc401b948da8f2e85a84391ae9e
Autor:
Hui Che, Zhiqiang Shao, Jiangchen Ding, Hua Gao, Xiangyu Liu, Hailong Chen, Shuangyu Cai, Jiaying Ge, Chengqiang Wang, Jun Wu, Yuefeng Hao
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells with a secretory phenotype that keeps the extracellular matrix (ECM) balanced and the cartilage environment stable
Externí odkaz:
https://doaj.org/article/8aa7427c2b1946889595e8b1bf1e4c97
Autor:
Lídia Faria, Sara Canato, Tito T. Jesus, Margarida Gonçalves, Patrícia S. Guerreiro, Carla S. Lopes, Isabel Meireles, Eurico Morais-de-Sá, Joana Paredes, Florence Janody
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/d764c050f338408c88e9525ea1c62e25
Autor:
Kendell M. Pawelec, Megan Varnum, Jack R. Harkema, Bruce Auerbach, Scott D. Larsen, Richard R. Neubig
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 6, Pp n/a-n/a (2022)
Abstract Bleomycin‐induced lung fibrosis is a debilitating disease, linked to high morbidity and mortality in chemotherapy patients. The MRTF/SRF transcription pathway has been proposed as a potential therapeutic target, as it is critical for myofi
Externí odkaz:
https://doaj.org/article/44200ee4fb6143fda9eddfcf3ba10f31