Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mrk Alley"'
Autor:
Pamela Berry, Yasheen Zhou, David S. Carter, Jason Halladay, Courtney Hastings, Vincent Hernandez, Bjorn Sunde, Weimin Mao, James C. Sacchettini, Aaron Korkegian, Wai Choi, Peter J. Tonge, Mrk Alley, Anne J. Lenaerts, Yi Xia, Gregory T. Robertson, Michael S. Scherman, Tanya Parish, Lisa K. Woolhiser, Veronica Gruppo, Lindsay Flint, Thomas R. Ioerger, Theresa O’Malley, Matthew B. McNeil
Publikováno v:
Life Science Alliance
AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis, good oral bioavailability, and comparable efficacy to isoniazid in infection models.
New antitubercular ag
New antitubercular ag
Autor:
Cummings JE; Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America., Lunde CS; AN2 Therapeutics, Menlo Park, California, United States of America., Alley MRK; AN2 Therapeutics, Menlo Park, California, United States of America., Slayden RA; Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
Publikováno v:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Nov 27; Vol. 17 (11), pp. e0011795. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).
Autor:
Robertson GT; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA gregory.robertson@colostate.edu., Ektnitphong VA; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., Scherman MS; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., McNeil MB; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Dennison D; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Korkegian A; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Smith AJ; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA., Halladay J; Anacor Pharmaceuticals, Palo Alto, California, USA., Carter DS; Anacor Pharmaceuticals, Palo Alto, California, USA., Xia Y; Anacor Pharmaceuticals, Palo Alto, California, USA., Zhou Y; Anacor Pharmaceuticals, Palo Alto, California, USA., Choi W; Anacor Pharmaceuticals, Palo Alto, California, USA., Berry PW; Anacor Pharmaceuticals, Palo Alto, California, USA., Mao W; Anacor Pharmaceuticals, Palo Alto, California, USA., Hernandez V; Anacor Pharmaceuticals, Palo Alto, California, USA., Alley MRK; Anacor Pharmaceuticals, Palo Alto, California, USA., Parish T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Lenaerts AJ; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Publikováno v:
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Mar 27; Vol. 63 (4). Date of Electronic Publication: 2019 Mar 27 (Print Publication: 2019).
Autor:
Wall RJ; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Rico E; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Lukac I; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Zuccotto F; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Elg S; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Gilbert IH; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Freund Y; Anacor Pharmaceuticals, Inc., Palo Alto, CA 94303., Alley MRK; Anacor Pharmaceuticals, Inc., Palo Alto, CA 94303., Field MC; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Wyllie S; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom., Horn D; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, DD1 5EH Dundee, United Kingdom; d.horn@dundee.ac.uk.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 18; Vol. 115 (38), pp. 9616-9621. Date of Electronic Publication: 2018 Sep 05.
Autor:
Zhang N; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Zoltner M; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Leung KF; Department of Pathology, University of Cambridge, Cambridge, United Kingdom., Scullion P; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Hutchinson S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Del Pino RC; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Vincent IM; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Zhang YK; Anacor Pharmaceuticals, Inc., Palo Alto, California, United States of America., Freund YR; Anacor Pharmaceuticals, Inc., Palo Alto, California, United States of America., Alley MRK; Anacor Pharmaceuticals, Inc., Palo Alto, California, United States of America., Jacobs RT; Anacor Pharmaceuticals, Inc., Palo Alto, California, United States of America., Read KD; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Barrett MP; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Horn D; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Field MC; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Publikováno v:
PLoS pathogens [PLoS Pathog] 2018 Feb 09; Vol. 14 (2), pp. e1006850. Date of Electronic Publication: 2018 Feb 09 (Print Publication: 2018).
Autor:
Korkegian A; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA., O'Malley T; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA., Xia Y; Anacor Pharmaceuticals, Palo Alto, CA, USA., Zhou Y; Anacor Pharmaceuticals, Palo Alto, CA, USA., Carter DS; Anacor Pharmaceuticals, Palo Alto, CA, USA., Sunde B; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA., Flint L; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA., Thompson D; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA., Ioerger TR; Texas A&M University, College Station, TX, USA., Sacchettini J; Texas A&M University, College Station, TX, USA., Alley MRK; Anacor Pharmaceuticals, Palo Alto, CA, USA., Parish T; TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA. Electronic address: tanya.parish@idri.org.
Publikováno v:
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2018 Jan; Vol. 108, pp. 96-98. Date of Electronic Publication: 2017 Nov 07.
Autor:
Li X; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Hernandez V; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Rock FL; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Choi W; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Mak YSL; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Mohan M; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Mao W; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Zhou Y; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Easom EE; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Plattner JJ; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Zou W; BioDuro LLC , Building E, No. 29, Life Science Park Road, Beijing 102206, P. R. China., Pérez-Herrán E; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Giordano I; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Mendoza-Losana A; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Alemparte C; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Rullas J; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Angulo-Barturen I; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Crouch S; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Ortega F; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Barros D; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Alley MRK; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2017 Oct 12; Vol. 60 (19), pp. 8011-8026. Date of Electronic Publication: 2017 Sep 27.
Autor:
Patel N; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., O'Malley T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Zhang YK; Anacor Pharmaceuticals, Palo Alto, California, USA., Xia Y; Anacor Pharmaceuticals, Palo Alto, California, USA., Sunde B; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Flint L; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Korkegian A; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA., Ioerger TR; Texas A&M University, College Station, Texas, USA., Sacchettini J; Texas A&M University, College Station, Texas, USA., Alley MRK; Anacor Pharmaceuticals, Palo Alto, California, USA., Parish T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA tanya.parish@idri.org.
Publikováno v:
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Aug 24; Vol. 61 (9). Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).
Autor:
Jones SE; Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK1., Ferguson NL; Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK1., Alley MRK; Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK1.
Publikováno v:
Microbiology (Reading, England) [Microbiology (Reading)] 2001 Apr; Vol. 147 (Pt 4), pp. 949-958.