Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Mritunjay, Pandey"'
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Akademický článek
RIT1 deficiency alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities
Autor: Lei Wu, Fang Wang, Carole L. Moncman, Mritunjay Pandey, Harrison A. Clarke, Hilaree N. Frazier, Lyndsay E.A. Young, Matthew S. Gentry, Weikang Cai, Olivier Thibault, Ramon C. Sun, Douglas A. Andres
Publikováno v: Heliyon, Vol 9, Iss 10, Pp e20384- (2023)
Oligodendrocytes (OLs) generate lipid-rich myelin membranes that wrap axons to enable efficient transmission of electrical impulses. Using a RIT1 knockout mouse model and in situ high-resolution matrix-assisted laser desorption/ionization mass spectr
Externí odkaz: https://doaj.org/article/2e0d1f068cc041c7a0e3fabd60fce283
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2
Akademický článek
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors
Autor: Mritunjay Pandey, Jian-Hua Zhang, Poorni R. Adikaram, Claire Kittock, Nicole Lue, Adam Awe, Katherine Degner, Nirmal Jacob, Jenna Staples, Rachel Thomas, Allison B. Kohnen, Sundar Ganesan, Juraj Kabat, Ching-Kang Chen, William F. Simonds
Publikováno v: JCI Insight, Vol 8, Iss 13 (2023)
Mechanical, thermal, and chemical pain sensation is conveyed by primary nociceptors, a subset of sensory afferent neurons. The intracellular regulation of the primary nociceptive signal is an area of active study. We report here the discovery of a G
Externí odkaz: https://doaj.org/article/04100bd6616e4b5b8c76a81a09c61a61
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3
Akademický článek
A Study on Anatomical Variations of Sacral Foramina and its Clinical Relevance
Autor: MRITUNJAY PANDEY
Publikováno v: International Journal of Anatomy Radiology and Surgery, Vol 10, Iss 1, Pp AC10-AC12 (2021)
Introduction: The Sacrum is a large, triangular, shield-shaped bony structure, formed by the fusion of five individual sacral vertebrae. Ventral surface of sacrum bears four pelvic sacral foramina allowing the passage of ventral rami of upper four
Externí odkaz: https://doaj.org/article/c2e6008b7c694e8cbb1b62d1f1898fb7
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4
Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity
Autor: Lee S. Weinstein, Mritunjay Pandey, Oksana Gavrilova, Hui Sun, Zhenzhong Cui, Min Chen, Marshal T Jahnke, Eric A. Wilson, Peter Metzger
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 320:E270-E280
This paper demonstrates that signaling within the dorsomedial hypothalamus via the G proteins Gqα and G11α, which couple cell surface receptors to the stimulation of phospholipase C, is critical for regulation of energy expenditure, thermoregulatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd0691f1cd254d164ef628e18fb8624d
https://doi.org/10.1152/ajpendo.00059.2020
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7
Development of R7BP inhibitors through cross-linking coupled mass spectrometry and integrated modeling
Autor: Sergio A. Hassan, Poorni R. Adikaram, Jian-Hua Zhang, Claire Kittock, Guanghui Wang, William F. Simonds, Marjan Gucek, Mritunjay Pandey, Nicole G Lue
Publikováno v: Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Communications Biology
Protein-protein interaction (PPI) networks are known to be valuable targets for therapeutic intervention; yet the development of PPI modulators as next-generation drugs to target specific vertices, edges, and hubs has been impeded by the lack of stru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e78abcd4fe2e06e8b6e6d24cdc3f72
http://link.springer.com/article/10.1038/s42003-019-0585-1
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8
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Autor: Eric A, Wilson, Hui, Sun, Zhenzhong, Cui, Marshal T, Jahnke, Mritunjay, Pandey, Peter, Metzger, Oksana, Gavrilova, Min, Chen, Lee S, Weinstein
Publikováno v: Am J Physiol Endocrinol Metab
The G-protein subunits G(q)α and G(11)α (G(q/11)α) couple receptors to phospholipase C, leading to increased intracellular calcium. In this study we investigated the consequences of G(q)/(11)α deficiency in the dorsomedial hypothalamus (DMH), a c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58c432455e3eaf4ed884b1ae7013abb3
https://pubmed.ncbi.nlm.nih.gov/33166186
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9
Huntington’s disease: the coming of age
Autor: Mritunjay Pandey, Usha Rajamma
Publikováno v: Journal of Genetics. 97:649-664
Huntington’s disease (HD) is caused due to an abnormal expansion of polyglutamine repeats in the first exon of huntingtin gene. The mutation in huntingtin causes abnormalities in the functioning of protein, leading to deleterious effects ultimately
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b94f1a2df6adda26ffe4f026c8cd420
https://doi.org/10.1007/s12041-018-0957-1
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