Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mrinal Y Shah"'
Autor:
Relja Popovic, Eva Martinez-Garcia, Eugenia G Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y Shah, Yupeng Zheng, Christine M Will, Eliza C Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A Calogero, William L Kath, Neil L Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D Licht
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004566 (2014)
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and
Externí odkaz:
https://doaj.org/article/293a2a508f7f439b86ca58f29cbbee55
Autor:
Lucy A. Godley, Peter Pytel, Ari Melnick, Ivan P. Moskowitz, Michelle M. Le Beau, John Anastasi, Shang Lin, Elizabeth M. Davis, Kelly R. Ostler, Christopher Hendrick, Anna Kamp, Maria E. Figueroa, Natalie Y. Barnes, Aparna Vasanthakumar, Mrinal Y. Shah
Epigenetic changes are among the most common alterations observed in cancer cells, yet the mechanism by which cancer cells acquire and maintain abnormal DNA methylation patterns is not understood. Cancer cells have an altered distribution of DNA meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf78fb6a0b518472181141de8f97485
https://doi.org/10.1158/0008-5472.c.6500267
https://doi.org/10.1158/0008-5472.c.6500267
Autor:
Lucy A. Godley, Peter Pytel, Ari Melnick, Ivan P. Moskowitz, Michelle M. Le Beau, John Anastasi, Shang Lin, Elizabeth M. Davis, Kelly R. Ostler, Christopher Hendrick, Anna Kamp, Maria E. Figueroa, Natalie Y. Barnes, Aparna Vasanthakumar, Mrinal Y. Shah
Supplementary Methods, Figures 1-10, Tables 1-8 from DNMT3B7, a Truncated DNMT3B Isoform Expressed in Human Tumors, Disrupts Embryonic Development and Accelerates Lymphomagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9203724fde80174196b7187e82df5ddc
https://doi.org/10.1158/0008-5472.22382627.v1
https://doi.org/10.1158/0008-5472.22382627.v1
Autor:
Jude M. Phillip, Madonna P. Phillip, Jonathan D. Licht, Relja Popovic, Christine Will, Eva Martinez-Garcia, Teresa Ezponda, Paola Neri, Nizar J. Bahlis, Mrinal Y. Shah, Eliza C. Small, Denis Wirtz, Allison B Chambliss
Publikováno v:
Oncogene
MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)+ multiple myeloma (MM) patients, believed to be the driving factor in the pathogenesis of this MM subtype. MMSET overexpression in MM leads to an increase in histone 3 lysine 3
Autor:
Antonino Neri, Yupeng Zheng, Jonathan D. Licht, Dong-Joon Min, Relja Popovic, Teresa Ezponda, Eva Martinez-Garcia, Jindan Yu, Christine Will, Neil L. Kelleher, Mrinal Y. Shah
Publikováno v:
Oncogene
Epigenetic deregulation of gene expression plays a role in the initiation and progression of prostate cancer (PCa). The histone methyltransferase MMSET/WHSC1 (Multiple Myeloma Set Domain) is overexpressed in a number of metastatic tumors, but its mec
Autor:
William L. Kath, Neil L. Kelleher, Eugenia G. Giannopoulou, Ji Ping Wang, Qingyang Zhang, Mrinal Y. Shah, Olivier Elemento, Jonathan D. Licht, Matteo Carrara, Yanwen Jiang, Yupeng Zheng, Eva Martinez-Garcia, Eliza C. Small, Relja Popovic, Marinka Bulic, Raffaele A. Calogero, Quanwei Zhang, Youjia Hua, Teresa Ezponda, Christine Will
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 10, Iss 9, p e1004566 (2014)
PLoS Genetics, Vol 10, Iss 9, p e1004566 (2014)
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and
Publikováno v:
Therapeutic advances in hematology. 4(2)
A growing amount of evidence points towards alterations in epigenetic machinery as a leading cause in disease initiation and progression. Like genetic alterations, misregulation of the epigenetic regulators can lead to abnormal gene expression. Howev
Autor:
Jonathan D. Licht, Mrinal Y. Shah
Publikováno v:
The Hematologist. 8
Autor:
Elizabeth M. Davis, Peter Pytel, Maria E. Figueroa, John Anastasi, Michelle M. Le Beau, Aparna Vasanthakumar, Natalie Y. Barnes, Anna Kamp, Ivan P. Moskowitz, Shang Lin, Ari Melnick, Christopher Hendrick, Mrinal Y. Shah, Lucy A. Godley, Kelly R. Ostler
Epigenetic changes are among the most common alterations observed in cancer cells, yet the mechanism by which cancer cells acquire and maintain abnormal DNA methylation patterns is not understood. Cancer cells have an altered distribution of DNA meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b25112c7c2f535bdf57bf4146cac735
https://europepmc.org/articles/PMC2905468/
https://europepmc.org/articles/PMC2905468/
Autor:
Jonathan D. Licht, Mrinal Y. Shah
Publikováno v:
Nature Genetics. 43:289-290
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutan