Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mrinal Shekhar"'
Autor:
Shamayeeta Ray, Samuel P Berry, Eric A Wilson, Casey H Zhang, Mrinal Shekhar, Abhishek Singharoy, Rachelle Gaudet
Publikováno v:
eLife, Vol 12 (2023)
Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By supporting metal homeostasis, Nramps prevent diseases and disorders related to metal insufficie
Externí odkaz:
https://doaj.org/article/31a6a8e80ee44293aea58786ccac961d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
High-throughput screening (HTS) methods enable the empirical evaluation of a large scale of compounds and can be augmented by virtual screening (VS) techniques to save time and money by using potential active compounds for experimental testing. Struc
Externí odkaz:
https://doaj.org/article/535ef8d01e024811995501da78009c18
Autor:
Ruyu Jia, Chloe Martens, Mrinal Shekhar, Shashank Pant, Grant A. Pellowe, Andy M. Lau, Heather E. Findlay, Nicola J. Harris, Emad Tajkhorshid, Paula J. Booth, Argyris Politis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
XylE is a bacterial xylose transporter and homologue of human glucose transporters GLUTs 1-4. HDX-MS, mutagenesis and MD simulations suggest that protonation of a conserved aspartate triggers conformational transition from outward- to inward facing s
Externí odkaz:
https://doaj.org/article/d6cb78ca4eb8432388486c3f0d334672
Autor:
Ali Dashti, Ghoncheh Mashayekhi, Mrinal Shekhar, Danya Ben Hail, Salah Salah, Peter Schwander, Amedee des Georges, Abhishek Singharoy, Joachim Frank, Abbas Ourmazd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the function
Externí odkaz:
https://doaj.org/article/a9730a6e4420466a99ccf8fd2dbeaec2
Autor:
Chloe Martens, Mrinal Shekhar, Antoni J. Borysik, Andy M. Lau, Eamonn Reading, Emad Tajkhorshid, Paula J. Booth, Argyris Politis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Secondary transporters catalyse substrate translocation across the cell membrane but the role of lipids during the transport cycle remains unclear. Here authors used hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations to
Externí odkaz:
https://doaj.org/article/3878486fe69c4a06a829c58c6f048e54
Autor:
Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Mrinal Shekhar, Marcus Tötzl, Matthew G. Rees, Andrew D. Cherniack, Matthew Meyerson, Heidi Greulich
Publikováno v:
Nature Chemical Biology. 19:301-310
Autor:
Erica N. Parker, Brett N. Cain, Behnoush Hajian, Rebecca J. Ulrich, Emily J. Geddes, Sulyman Barkho, Hyang Yeon Lee, John D. Williams, Malik Raynor, Diana Caridha, Angela Zaino, Mrinal Shekhar, Kristen A. Muñoz, Kara M. Rzasa, Emily R. Temple, Diana Hunt, Xiannu Jin, Chau Vuong, Kristina Pannone, Aya M. Kelly, Michael P. Mulligan, Katie K. Lee, Gee W. Lau, Deborah T. Hung, Paul J. Hergenrother
Publikováno v:
ACS Central Science. 8:1145-1158
Autor:
Shamayeeta Ray, Samuel P. Berry, Eric A. Wilson, Casey H. Zhang, Mrinal Shekhar, Abhishek Singharoy, Rachelle Gaudet
Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By supporting metal homeostasis, Nramps prevent disorders related to metal insufficiency or overlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33217888a801279e2a18f2045f8fd2c4
https://doi.org/10.1101/2022.09.08.507188
https://doi.org/10.1101/2022.09.08.507188
Autor:
Mrinal Shekhar, Chitrak Gupta, Kano Suzuki, Chun Kit Chan, Takeshi Murata, Abhishek Singharoy
Publikováno v:
ACS central science. 8(7)
The mechanism of rotatory catalysis in ATP-hydrolyzing molecular motors remains an unresolved puzzle in biological energy transfer. Notwithstanding the wealth of available biochemical and structural information inferred from years of experiments, kno