Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mridusmita Saikia"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a26d037bf40747dda6b2c48162b5213a
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells. Therapies targeting the GLP-1 receptor (GLP-1R) use the classical incretin model as a ph
Externí odkaz:
https://doaj.org/article/2cd53a8838c742bdbd5a056e2f5d1475
Autor:
Mridusmita Saikia, Marlena M. Holter, Leanne R. Donahue, Isaac S. Lee, Qiaonan C. Zheng, Journey L. Wise, Jenna E. Todero, Daryl J. Phuong, Darline Garibay, Reilly Coch, Kyle W. Sloop, Adolfo Garcia-Ocana, Charles G. Danko, Bethany P. Cummings
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under certain circumstances α cells can express the prohormone convertase required f
Externí odkaz:
https://doaj.org/article/d8231da5c1ae478aaa15444e8576fb6f
Autor:
Marlena M. Holter, Daryl J. Phuong, Isaac Lee, Mridusmita Saikia, Lisa Weikert, Samantha Fountain, Elizabeth T. Anderson, Qin Fu, Sheng Zhang, Kyle W. Sloop, Bethany P. Cummings
Publikováno v:
Science advances. 8(29)
Recent studies demonstrate that α cells contribute to glucose-stimulated insulin secretion (GSIS). Glucagon-like peptide-1 receptor (GLP-1R) agonists potently potentiate GSIS, making these drugs useful for diabetes treatment. However, the role of α
Autor:
MARLENA HOLTER, DARYL PHUONG, ISAAC S.H. LEE, MRIDUSMITA SAIKIA, LISA A. WEIKERT, ELIZABETH T. ANDERSON, QIN FU, SHENG ZHANG, KYLE SLOOP, BETHANY CUMMINGS
Publikováno v:
Diabetes. 71
Glucagon like peptide 1 (GLP1) , a classically gut derived hormone, potentiates insulin secretion. New evidence suggests that α cells can produce GLP1 under certain conditions, which may offer a novel therapeutic modality for treating diabetes; howe
Autor:
Marlena M. Holter, Adolfo Garcia-Ocana, Mridusmita Saikia, Charles G. Danko, Bethany Cummings, Darline Garibay
Publikováno v:
Diabetes. 69
Glucagon-like peptide-1 (GLP-1) regulates islet function by enhancing glucose-stimulated insulin secretion (GSIS). We previously found that the beta cell GLP-1 receptor (GLP-1R) contributes to improvements in glucose regulation and islet function in
Autor:
Darline Garibay, Seon A. Lee, Erin K. Daugherity, Elizabeth S. Moore, Mridusmita Saikia, Robert S. Weiss, Paul Cohen, Marlena M. Holter, Kathleen Kelly, Anne K. McGavigan, Lily Ngyuen, Bethany P. Cummings
Publikováno v:
FASEB J
P53 has been implicated in the pathogenesis of obesity and diabetes; however, the mechanisms and tissue sites of action are incompletely defined. Therefore, we investigated the role of hepatocyte p53 in metabolic homeostasis using a hepatocyte-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32e0107bd7f4f90b5acf34d7b023655
https://europepmc.org/articles/PMC8884714/
https://europepmc.org/articles/PMC8884714/
Autor:
Julia Miller, Seth A. Peng, Mridusmita Saikia, Joby M. Cowulich, Christina A. Mazulis, Elia D. Tait Wojno, Rebecca L. Cubitt, William H. Miller, Charles G. Danko, Lauren M. Webb, Oyebola O. Oyesola, Simon P. Früh, Jeremy Eule
Publikováno v:
Veterinary immunology and immunopathology. 221
Atopic dermatitis (AD) is an allergic skin disease that causes significant morbidity and affects multiple species. AD is highly prevalent in companion dogs, and the clinical management of the disease remains challenging. An improved understanding of
Autor:
Iwijn De Vlaminck, Mridusmita Saikia, Philip Burnham, Sara H. Keshavjee, Michael F. Z. Wang, Michael Heyang, Pablo Moral-Lopez, Meleana M. Hinchman, Charles G. Danko, John S. L. Parker
Here we describe the step-by-step protocol of Droplet Assisted RNA Targeting by single cell sequencing \(DART-seq). DART-seq allows simultaneous multiplexed amplicon sequencing and transcriptome analysis in single cells. Using a simple and quick modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ded8bff321b41fda224ce10523ba4d
https://doi.org/10.21203/rs.2.1655/v1
https://doi.org/10.21203/rs.2.1655/v1
Publikováno v:
RNA. 22:1719-1727
It is common wisdom that codon usage bias has evolved in the selection for efficient translation, in which highly expressed genes are encoded predominantly by optimal codons. However, a growing body of evidence suggests regulatory roles for non-optim