Výsledky vyhledávání - "Mridula Chandan-Langlie"

Differential Effects of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) on the Radiation Sensitivity of Normal Versus Leukemic Bone Marrow Progenitor Cell Populations

Autor: Kevin G. Waddick, Mridula Chandan-Langlie, Fatih M. Uckun

Publikováno v: Leukemia & Lymphoma. 25:77-90

We examined the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF), interleukin 3 (rhIL-3) and interleukin 6 (rhIL-6) on the radiation sensitivity of normal and leukemic bone marrow progenitor cell populations. Conditioning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebd9db8b12609345e15a3a28dde969e
https://doi.org/10.3109/10428199709042498

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Granulocyte-Macrophage colony-Stimulating factor receptor-Targeted therapy of chemotherapy- and radiation-Resistant human myeloid leukemias

Autor: Kevin G. Waddick, Stella M. Davies, Berta Warman, Anne Bendel, Yu Shao, Chang H. Yang, Mridula Chandan-Langlie, Fatih M. Uckun, John P. Perentesis

Publikováno v: Leukemia & Lymphoma. 25:247-256

Contemporary therapies for acute myeloid leukemia (AML) commonly fail to cure patients because of the emergence of drug resistance. Drug resistance in AML is multifactorial but can be associated with the overexpression of transmembrane transporter mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26261827d8ca78b3bcf833f7209711ec
https://doi.org/10.3109/10428199709114164

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In Vitro and in Vivo Anti-Leukemic Efficacy of Cyclic AMP Modulating Agents Against Human Leukemic B-cell Precursors

Autor: Dorothea E. Myers, Lisa M. Chelstrom, Mridula Chandan-Langlie, Fatih M. Uckun

Publikováno v: Leukemia & Lymphoma. 22:259-264

We show that the adenylate cyclase activating diterpine, forskolin, the phosphodiesterase inhibitor, aminophylline, and the permeant cAMP analog dibutyryl cAMP inhibit the in vitro clonogenic growth of leukemic B-cell precursors. We also used a SCID

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428e2a822c6b92c073ad83f5adeacfb7
https://doi.org/10.3109/10428199609051756

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In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells

Autor: Dorothea E. Myers, Mridula Chandan-Langlie, Kevin G. Waddick, Lisa M. Chelstrom, Nilgun Tumer, Fatih M. Uckun, J. D. Irvin, Roland Gunther

Publikováno v: Blood. 86:4228-4233

B-cell precursor (BCP) leukemia is the most common form of childhood cancer and represents one of the most radiation-resistant forms of human malignancy. In this study, we examined the antileukemic efficacy of the B43 (anti-CD19)-pokeweed antiviral p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1299e72dad8365d2638150a8e17e8520
https://doi.org/10.1182/blood.v86.11.4228.bloodjournal86114228

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In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells

Autor: Mridula Chandan-Langlie, Clinton F. Stewart, Lisa M. Chelstrom, William E. Evans, Kevin G. Waddick, Fatih M. Uckun, Jizhong Jin, G Reaman, James G. White

Publikováno v: Blood. 85:2817-2828

Topotecan [(S)-9-dimethylaminomethyl-10-hydroxycamptothecin hydrochloride; SK&F 104864-A, NSC 609699], a water soluble semisynthetic analogue of the alkaloid camptothecin, is a potent topoisomerase I inhibitor. Here we show that topotecan stabilizes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2ed259ac2a6e6f445aad98b2a95744a
https://doi.org/10.1182/blood.v85.10.2817.bloodjournal85102817

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Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia

Autor: K G Waddick, Mridula Chandan-Langlie, Chang W. Song, Kazimiera J. Gajl-Peczalska, F. M. Uckun, W Jaszcz

Publikováno v: Journal of Clinical Investigation. 91:1044-1051

The radiation sensitivity of primary clonogenic blasts from 44 children with newly diagnosed B-cell precursor acute lymphoblastic leukemia (ALL) was analyzed using leukemic progenitor cell (LPC) colony assays. The derived values for SF2 (surviving fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624e320817883cac1077ee8390a7c564
https://doi.org/10.1172/jci116261

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Interleukin 3 Stimulation Enhances Tyrosine Phosphorylation and Proliferative Activity of Human Fetal Thymocytes and Leukemic T-cell Precursors at Multiple Developmental Stages of T-Cell Ontogeny

Autor: Gary L. Schieven, Fatih M. Uckun, Mildred Hanson, Mridula Chandan-langlie, Dean Discher, Vedat Obuz, Jeffrey A. Ledbetter, Ilker Dibirdik, Lisa Tuel-ahlgren

Publikováno v: Leukemia & Lymphoma. 6:117-132

The purposes of this study were to elucidate the biologic effects of recombinant human interleukin 3 (rhIL-3) on leukemia T-cell precursors and fetal thymocytes corresponding to discrete and sequential developmental stages of human T-cell ontogeny, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7f0f7512348ecad6d4afbc012e5df7b
https://doi.org/10.3109/10428199209064887

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In vitro and in vivo radiation resistance associated with CD3 surface antigen expression in T-lineage acute lymphoblastic leukemia

Autor: Mridula Chandan-Langlie, Norma K.C. Ramsay, Robert Haake, Waclaw Jaszcz, Kevin G. Waddick, John H. Kersey, Fatih M. Uckun, Chang W. Song, Kazimiera J. Gajl-Peczalska, Vedat Obuz

Publikováno v: Blood. 78:2945-2955

The radiobiologic features of primary clonogenic blasts (referred to also as T-lineage leukemic progenitor cells) from newly diagnosed and relapsed T-lineage acute lymphoblastic leukemia (ALL) patients were analyzed. Intrinsic radiation sensitivity d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::064fd32debfc411c780119a915b161e5
https://doi.org/10.1182/blood.v78.11.2945.2945

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Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny

Autor: Mridula Chandan-Langlie, Gary L. Schieven, Ilker Dibirdik, Jeffrey A. Ledbetter, Fatih M. Uckun, Lisa Tuel-Ahlgren

Publikováno v: Journal of Biological Chemistry. 266:17478-17485

CD40/Bp50 B-cell receptor has been implicated as having an important function for the regulation of human B-cell growth and maturation as well as antigen-driven selection of tonsillar B-cells in germinal centers. The purpose of the present study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80e722d172fa01bbecb89ff8c7d13a87
https://doi.org/10.1016/s0021-9258(19)47397-3

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Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells

Autor: Lisa Tuel-Ahlgren, Vedat Obuz, Kazimiera J. Gajl-Peczalska, Gary L. Schieven, Jeffrey A. Ledbetter, Ilker Dibirdik, Mridula Chandan Langlie, Kevin G. Waddick, Fatih M. Uckun

Publikováno v: Blood. 78:564-570

The purposes of this study were to examine the biologic effects of the engagement of the interleukin-7 receptor (IL-7R) with recombinant human interleukin-7 (rhIL-7) in immunophenotypically distinct T-lineage acute lymphoblastic leukemia (ALL) blasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23c18fcfd2673466b079e2ad07b13436
https://doi.org/10.1182/blood.v78.3.564.564

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