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Abstract 4943: Leveraging single-cell sequencing to discover novel exhaustion markers of CD8 T cells
Autor:
Xiaoshan Shi, Amit Chaudhuri, Papia Chakraborty, Vasumathi Kode, Kayla Lee, Keshav Bhojak, Savita Jayaram, Ashwini Patil, Ravi Gupta, Mridul Chaudhary
Publikováno v:
Cancer Research. 79:4943-4943
Therapeutic revival of tumor-specific exhausted T cells using checkpoint blockade antibodies has improved clinical outcomes in cancer significantly. Notwithstanding a high overall response rate to these drugs, long-term benefit is realized by a small