Zobrazeno 1 - 10
of 591
pro vyhledávání: '"Mre11 complex"'
Autor:
Kirill S. Lobachev, Ziwei Sheng, Alex B Costa, Wenying Guo, Anissia Ait Saada, James E. Haber
Publikováno v:
Nucleic Acids Research
Palindromic sequences are a potent source of chromosomal instability in many organisms and are implicated in the pathogenesis of human diseases. In this study, we investigate which nucleases are responsible for cleavage of the hairpin and cruciform s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09eb758baa60ef89c0f34df435f7299
https://doi.org/10.1093/nar/gkab168
https://doi.org/10.1093/nar/gkab168
Autor:
Malgorzata Grosbart, John H.J. Petrini, Jun Hyun Kim, Claire Wyman, Roopesh Anand, Petr Cejka
Publikováno v:
Cell Reports, 18(2), 496-507. Cell Press
Cell Reports, Vol 18, Iss 2, Pp 496-507 (2017)
Cell Reports, Vol 18, Iss 2, Pp 496-507 (2017)
Summary: The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d257549f700638279c7b776303dae58
https://doi.org/10.1016/j.celrep.2016.12.035
https://doi.org/10.1016/j.celrep.2016.12.035
Autor:
Antoine Marmignon, Julia Godau, Anika Trenner, Christine von Aesch, Emeline Dubois, Aurélie Kapusta, Mireille Bétermier, Lauriane Simon, Lorenza P. Ferretti, Alessandro A. Sartori, Raphael Guerois
Publikováno v:
DNA Repair
DNA Repair, 2019, 77, pp.96--108. ⟨10.1016/j.dnarep.2019.03.011⟩
DNA Repair, 2019, 77, pp.96--108. ⟨10.1016/j.dnarep.2019.03.011⟩
International audience; DNA double-strand breaks (DSBs) induced by genotoxic agents can cause cell death or contribute to chromosomal instability, a major driving force of cancer. By contrast, Spo11-dependent DSBs formed during meiosis are aimed at g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7ddca2c8d6912929c30e3577d13cbd
https://hal.science/hal-02171008
https://hal.science/hal-02171008
Publikováno v:
Proceedings of the National Academy of Sciences. 115:8793-8798
Collapsed replication forks, which are a major source of DNA double-strand breaks (DSBs), are repaired by sister chromatid recombination (SCR). The Mre11–Rad50–Nbs1 (MRN) protein complex, assisted by CtIP/Sae2/Ctp1, initiates SCR by nucleolytical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aef0768b8005833e4586095e89e1bc
https://doi.org/10.1073/pnas.1808189115
https://doi.org/10.1073/pnas.1808189115
Autor:
Yunje Cho, Artur Krężel, Michał Padjasek, Kyeong Sik Jin, Eunyoung Jeong, Marcel Hohl, Young Bong Park, John H.J. Petrini
Publikováno v:
Nature structural & molecular biology
The Rad50 hook interface is crucial for assembly and various functions of the Mre11 complex. Previous analyses suggested that Rad50 molecules interact within (intracomplex) or between (intercomplex) dimeric complexes. In this study, we determined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55529fe8de7432a0d3d2cca851906e1a
http://europepmc.org/articles/PMC5625350
http://europepmc.org/articles/PMC5625350
Autor:
Jennifer A. Cobb, Peter M. J. Burgers, John H.J. Petrini, Barry S. Taylor, Fiorella Ghisays, Marcel Hohl, Dinshaw J. Patel, Matthew T. Chang, Sarem Hailemariam, Vitaly Kuryavyi, Kyle Sorenson, Aditya Mojumdar
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb38763df458c0e79dd3ff038d72d01
We derived a mouse model in which a mutant form of Nbs1 (Nbs1mid8) exhibits severely impaired binding to the Mre11-Rad50 core of the Mre11 complex. TheNbs1mid8allele was expressed exclusively in hematopoietic lineages (inNbs1-/mid8vavmice). UnlikeNbs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f6d8b08c6fdf5804d3b3ad755bc35
https://doi.org/10.1101/576082
https://doi.org/10.1101/576082
Autor:
Arthur J. Lustig
Publikováno v:
Trends Cell Biol
A mechanistic understanding of the yeast telomere requires an integrated understanding of telomere chromatin structure (telosomes), telomeric origins of replications, telomere length homeostasis, and telosome epigenetics. Recent molecular and genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f0c889064d9de054661d0071945fac
https://europepmc.org/articles/PMC6465155/
https://europepmc.org/articles/PMC6465155/
Akademický článek
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Autor:
Olga A. Guryanova, Ross L. Levine, Craig H. Bassing, Katherine S. Yang-lott, Jayanta Chaudhuri, John H.J. Petrini, Laura Nicolas, Alessia Balestrini
Publikováno v:
Molecular Cancer Research. 14:185-195
The Mre11 complex (Mre11, Rad50, and Nbs1) occupies a central node of the DNA damage response (DDR) network and is required for ATM activation in response to DNA damage. Hypomorphic alleles of MRE11 and NBS1 confer embryonic lethality in ATM-deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b6288832ae77c5978e7513eecafce6
https://doi.org/10.1158/1541-7786.mcr-15-0281
https://doi.org/10.1158/1541-7786.mcr-15-0281