Association of interleukin-1 gene polymorphisms with Alzheimer's disease

Autor: Nicoll, JA, Mrak, RE, Graham, DI, Stewart, J, Wilcock, G, MacGowan, S, Esiri, MM, Murray, LS, Dewar, D, Love, S, Moss, T, Griffin, WS

Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and Uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c5ea339fba88a5d71ccb2488cd9e2c77
https://ora.ox.ac.uk/objects/uuid:3783fdf4-503a-41a1-ad5c-8460d74f60f2

MAVS signaling shapes microglia responses to neurotropic virus infection.

Autor: Gern, Olivia Luise¹ (AUTHOR), Pavlou, Andreas¹ (AUTHOR), Mulenge, Felix¹ (AUTHOR), Busker, Lena Mareike^1,2 (AUTHOR), Ghita, Luca^1,3 (AUTHOR), Aringo, Angela¹ (AUTHOR), Costa, Bibiana¹ (AUTHOR), Spanier, Julia¹ (AUTHOR), Waltl, Inken¹ (AUTHOR), Stangel, Martin^4,5,6 (AUTHOR), Kalinke, Ulrich^1,7 (AUTHOR) Ulrich.kalinke@twincore.de

Publikováno v: Journal of Neuroinflammation. 10/18/2024, Vol. 21 Issue 1, p1-20. 20p.

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.

Autor: Balasubramaniam M; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Parcon PA; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Bose C; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Liu L; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Jones RA; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Geriatric Research Education and Clinical Center at the Central Arkansas Healthcare Veterans System, Little Rock, AR, 72205, USA., Farlow MR; Department of Neurology, Indiana Alzheimer Disease Center, Indiana University, Bloomington, USA., Mrak RE; Department of Pathology, University of Toledo Health Sciences Campus, Toledo, OH, 43614, USA., Barger SW; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Geriatric Research Education and Clinical Center at the Central Arkansas Healthcare Veterans System, Little Rock, AR, 72205, USA., Griffin WST; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. griffinsuet@uams.edu.; Geriatric Research Education and Clinical Center at the Central Arkansas Healthcare Veterans System, Little Rock, AR, 72205, USA. griffinsuet@uams.edu.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2019 Dec 27; Vol. 16 (1), pp. 275. Date of Electronic Publication: 2019 Dec 27.

PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia.

Autor: Hoyer-Kimura, Christina¹, Hay, Meredith^1,2,3 mhay@arizona.edu, Konhilas, John P.¹, Morrison, Helena W⁴, Methajit, Methawasin⁵, Strom, Joshua⁵, Polt, Robin⁶, Salcedo, Victoria¹, Fricks, Joshua P.³, Kalya, Anjna¹, Pires, Paulo W.¹

Publikováno v: Aging & Disease. Aug2024, Vol. 15 Issue 4, p1927-1951. 25p.

Herpes simplex virus 1 accelerates the progression of Alzheimer's disease by modulating microglial phagocytosis and activating NLRP3 pathway.

Autor: Wang, Zhimeng^1,2 (AUTHOR), Liu, Jing³ (AUTHOR), Han, Jing^1,2 (AUTHOR), Zhang, Tianyi⁴ (AUTHOR), Li, Shangjin⁴ (AUTHOR), Hou, Yanfei¹ (AUTHOR), Su, Huili¹ (AUTHOR), Han, Fangping¹ (AUTHOR), Zhang, Conggang^1,2 (AUTHOR) cgzhang@tsinghua.edu.cn

Publikováno v: Journal of Neuroinflammation. 7/18/2024, Vol. 21 Issue 1, p1-24. 24p.