Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mozhdeh Mahdavi"'
Autor:
Lynda Chin, Gordon B. Mills, Michael A. Davies, Kenneth Y. Tsai, Katherine Stemke-Hale, James M. Tepper, Zhuangna Fang, Guocan Wang, Giannicola Genovese, Tony Gutschner, Mozhdeh Mahdavi, Peter K. Cabeceiras, Liren Li, Ian R. Watson
Supplementary Table 1. (Top) IC50 (nM), fold changes (FC) and (Bottom) % viability at 10uM drug treatment compared to DMSO control for BRAF mutant cell lines, A375, MALME-3M, 451Lu and IGR1 (expresses RAC1 P29S) are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c4d7dbf863237d4b842c67149416ac
https://doi.org/10.1158/0008-5472.22404083
https://doi.org/10.1158/0008-5472.22404083
Autor:
Tony Gutschner, Peter K. Cabeceiras, Kenneth Y. Tsai, James Tepper, Giannicola Genovese, Michael A. Davies, Liren Li, Zhuangna Fang, Ian R. Watson, Katherine Stemke-Hale, Gordon B. Mills, Guocan Wang, Lynda Chin, Mozhdeh Mahdavi
Publikováno v:
Cancer Research. 74:4845-4852
Following mutations in BRAF and NRAS, the RAC1 c.85C>T single-nucleotide variant (SNV) encoding P29S amino acid change represents the next most frequently observed protein-coding hotspot mutation in melanoma. However, the biologic and clinical signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d392bf8aeb538a0042d54792cd358a
https://doi.org/10.1158/0008-5472.can-14-1232-t
https://doi.org/10.1158/0008-5472.can-14-1232-t
Autor:
Qian Peng, Levi A. Garraway, Qing Edward Chang, Kirsti Hornigold, Luigi Nezi, Kadir C. Akdemir, Stefan T. Arold, Heidi C.E. Welch, Lynda Chin, Kunal Rai, Samir B. Amin, Chia Chin Wu, Yonathan Lissanu Deribe, Yanxia Shi, Mozhdeh Mahdavi
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on chromosome 10) binding protein that is significantly mutated in cutaneous melanoma and pancreatic ductal adenocarcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12c5e857c3fe21dda8631b93192e243
https://europepmc.org/articles/PMC4780599/
https://europepmc.org/articles/PMC4780599/
Autor:
Peter K. Cabeceiras, Liren Li, Gordon B. Mills, Mozhdeh Mahdavi, Katherine Stemke-Hale, Lynda Chin, Ian R. Watson, Zhuangna Fang
Publikováno v:
Cancer Research. 74:LB-214
Following recurrent mutations in BRAF and NRAS, the RAC1 c.85C > T single nucleotide variant encoding P29S amino acid change represents the next most frequently observed hotspot mutation in melanoma. However, the biological and clinical relevance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15c4376ad3e9df46eb2eda3ac355ced3
https://doi.org/10.1158/1538-7445.am2014-lb-214
https://doi.org/10.1158/1538-7445.am2014-lb-214