Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease.

Autor: Gunder LC; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA., Johnson HR; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA., Yao E; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA., Moyer TH; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA., Green HA; Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53705, USA., Sherer N; McArdle Laboratory for Cancer Research and Institute for Molecular Virology, University of Wisconsin, 1111 Highland Avenue, Madison, WI 53706, USA., Zhang W; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, 3170 UW Medical Foundation Centennial Building (MFCB), 1685 Highland Avenue, Madison, WI 53705, USA.; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA., Carchman EH; Department of Surgery, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.; Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53705, USA.; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA.

Publikováno v: Viruses [Viruses] 2023 Apr 20; Vol. 15 (4). Date of Electronic Publication: 2023 Apr 20.

The use of a topical protease inhibitor, Saquinavir, to alleviate mouse papillomavirus-mediated anal disease.

Autor: Gunder LC; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA. Electronic address: gunderl@surgery.wisc.edu., Johnson HR; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA. Electronic address: hjohnson42@wisc.edu., Green HA; University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53705, USA. Electronic address: hagreen@uwcarbone.wisc.edu., Bilger A; McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Wisconsin Institutes for Medical Research, 1111 Highland Ave, Madison, WI, 53705, USA. Electronic address: bilger@oncology.wisc.edu., Moyer TH; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA. Electronic address: tmoyer2@wisc.edu., Zhang W; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 3170 UW Medical Foundation Centennial Building (MFCB),1685 Highland Avenue, Madison, WI, 53705, USA. Electronic address: wzhang566@wisc.edu., Ziolkowski MR; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA. Electronic address: mziolkowski@wisc.edu., Bertrang PA; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA. Electronic address: pbertrang@wisc.edu., Carchman EH; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA; University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53705, USA; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI, 53705, USA. Electronic address: carchman@surgery.wisc.edu.

Publikováno v: Virology [Virology] 2022 Nov; Vol. 576, pp. 96-104. Date of Electronic Publication: 2022 Sep 29.

Systemic Delivery of a Dual PI3K/mTOR Inhibitor More Effective than Topical Delivery in Preventing Anal Carcinogenesis in an HPV Transgenic Mouse Model.

Autor: Gunder LC; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA., Moyer TH; Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Ziolkowski MR; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA., Keating MK; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin, USA., Leverson GE; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA., Zhang W; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Carchman EH; Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, UW Health University Hospital, Madison, Wisconsin, USA.

Publikováno v: Journal of cancer science and clinical therapeutics [J Cancer Sci Clin Ther] 2022; Vol. 6 (2), pp. 157-173. Date of Electronic Publication: 2022 Apr 18.