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The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis.

Autor: Harrison BA; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Dowling JE; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Bursavich MG; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Troast DM; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Chong KM; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Hahn KN; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Zhong C; Chemistry, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Mulvihill KM; CMC, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Nguyen H; CMC, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Monroy MF; Molecular and Cellular Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Qiao Q; Molecular and Cellular Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Sosa B; Molecular and Cellular Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Mostafavi S; Molecular and Cellular Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Smukste I; DMPK, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Lee D; DMPK, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Cappellucci L; Screening Biology, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Konopka EH; Screening Biology, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Nowakowski P; Screening Biology, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Stawski L; Fibrosis, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Senices M; Fibrosis, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Nguyen MH; Fibrosis, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Kapoor PS; Fibrosis, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Luus L; Translational Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Sullivan A; Translational Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Bortolato A; Computational Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Svensson M; Computational Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Hickey ER; Medicinal Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Konze KD; Medicinal Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Day T; Computational Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Kim B; Computational Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Negri A; Computational Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Gerasyuto AI; Medicinal Chemistry, Therapeutics Group, Schrödinger, New York, New York 10036, United States., Moy TI; Screening Biology, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Lu M; Fibrosis, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Ray AS; Biology and Translational Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Wang L; Biology and Translational Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Cui D; DMPK, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Lin FY; Molecular and Cellular Sciences, Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Lippa B; Morphic Therapeutic, Waltham, Massachusetts 02451, United States., Rogers BN; Morphic Therapeutic, Waltham, Massachusetts 02451, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.

A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding.

Autor: Boudko SP; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Center for Matrix Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA. Electronic address: sergey.budko@vumc.org., Konopka EH; Morphic Therapeutic, Inc, Waltham, Massachusetts, USA., Kim W; Morphic Therapeutic, Inc, Waltham, Massachusetts, USA., Taga Y; Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan., Mizuno K; Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan., Springer TA; Department of Biological Chemistry and Molecular Pharmacology, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hudson BG; Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Center for Matrix Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA., Moy TI; Morphic Therapeutic, Inc, Waltham, Massachusetts, USA., Lin FY; Morphic Therapeutic, Inc, Waltham, Massachusetts, USA. Electronic address: albert.lin@morphictx.com.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104901. Date of Electronic Publication: 2023 Jun 10.