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Phase II Study of Sunitinib in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: GORTEC 2006-01

Autor: Denis Rommel, Joël Guigay, Emmanuelle Bompas, Anne-Françoise Dillies, Nicolas Michoux, Sandra Schmitz, Sandrine Faivre, Sylvie Zanetta, Marie-Christine Kaminsky, Thierry Duprez, Stéphanie Henry, Jean-Pascal Machiels, Anne Moxhon

Publikováno v: Journal of Clinical Oncology. 28:21-28

Purpose To assess the efficacy and toxicity of sunitinib monotherapy in palliative squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods Thirty-eight patients with SCCHN having evidence of progressive disease (PD) were treated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc6fd7e7e6135f0fd94c1c0f2c1b9e9
https://doi.org/10.1200/jco.2009.23.8584

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Panitumumab as a radiosensitizing agent in KRAS wild-type locally advanced rectal cancer

Autor: Thierry Delaunoit, Karin Haustermans, Anne Jouret-Mourin, Javier Carrasco, Nicolas Meert, Anne Moxhon, Yves Humblet, Feby Ingriani Mardjuadi, Marc Van den Eynde, Jean-François Daisne, Jean-Charles Coche, Christine Sempoux, Pierre Scalliet, Jean-Charles Goeminne, Jean-Pascal Machiels, Jean-Luc Canon, Peter Vuylsteke

Publikováno v: Targeted Oncology : biotherapies for the clinicians in oncology, Vol. 10, no. 3, p. 375-383 (2015)

Our goal was to optimize the radiosensitizing potential of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, when given concomitantly with preoperative radiotherapy in KRAS wild-type locally advanced rectal cancer (LARC). Based on p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9594678cb621d23a3ca9e03016a0ee2
https://pubmed.ncbi.nlm.nih.gov/25304881

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Phase I study of sorafenib in combination with docetaxel and prednisone in chemo-naïve patients with metastatic castration-resistant prostate cancer

Autor: Jacques Medioni, Flora T. Musuamba, Stéphane Oudard, Jean-Luc Canon, Marylene Clausse, Anne Moxhon, Feby Mardjuadi, Joseph Kerger, Lionel D'Hondt, Lionel Duck, Jean-Pascal Machiels

Publikováno v: Cancer chemotherapy and pharmacology. 70(2)

We performed a dose-escalation study to investigate the safety of sorafenib in combination with docetaxel and prednisone in chemo-naive patients with metastatic castration-resistant prostate cancer (mCRPC). Six patients were included per dose level.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25907008822a1448b085bf21fa86a09c
https://pubmed.ncbi.nlm.nih.gov/22752248

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Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: clinical activity and molecular response (GORTEC 2008-02)

Autor: Jean-Pascal Machiels, Joël Guigay, Marie-Christine Kaminsky-Forrett, Lionnel Geoffrois, Laurent Knoops, Emmanuelle Bompas, Sandra Schmitz, Sylvie Zanetta, Lionel Mignion, Marc Hamoir, Stéphanie Henry, Anne Moxhon

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 23(8)

BACKGROUND: Preclinical studies suggest that insulin-like growth factor-1 receptor (IGF-1R) blockage could be a promising therapeutic target in squamous cell carcinoma of the head and neck (SCCHN). Therefore, we investigated the efficacy and toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a242f821f9d08743827f44062d7572
https://pubmed.ncbi.nlm.nih.gov/22234739

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Prospective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancer

Autor: D. Verhoeven, Bertrand Tombal, Luc Marcelis, Marie-Alix Bonny, Lionel D'Hondt, B. Honhon, Joseph Kerger, Jean-Pascal Machiels, Anne-Marie Moxhon, Vincent Verschaeve, Peter Jousten, Lionel Duck, Filomena Mazzeo, Marylene Clausse, Catherine Dopchie, Bertrand Filleul

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(32)

Purpose To assess the efficacy and toxicity of the addition of estramustine to docetaxel (D) for the treatment of metastatic hormone-refractory prostate cancer. Patients and Methods One hundred fifty patients were randomly assigned to D alone (35 mg/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70757392714d14164ce53ebf2f00ae85
https://pubmed.ncbi.nlm.nih.gov/19171697

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Akademický článek

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ADJUVANT RADIATION THERAPY DOES NOT CAUSE URINARY INCONTINENCE AFTER RADICAL PROSTATECTOMY: RESULTS OF A PROSPECTIVE RANDOMIZED STUDY

Autor: Françoise Richard, Yves Castille, Francois X. Wese, Paul Van Cangh, Pierre Scaillet, Reinier-Jacques Opsomer, Luc De Visscher, Francis Lorge, Anne Moxhon

Publikováno v: Journal of Urology. 159:164-166

Purpose: We analyzed the potential influence of adjuvant radiotherapy on urinary continence after radical prostatectomy.Materials and Methods: A total of 100 patients with N0M0 prostate cancer randomized in a prospective study on postoperative radiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6556004cde28c049247bf59c91f5509
https://doi.org/10.1016/s0022-5347(01)64044-8

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Phase II trial of preoperative radiotherapy (RT) and panitumumab (PAN) in KRAS wild type (wt) rectal cancer (RC)

Autor: Yves Humblet, Javier Carrasco, Anne Moxhon, Anne Jouret-Mourin, Jean-Charles Coche, Christine Sempoux, Marc Van den Eynde, Peter Vuylsteke, Thierry Delaunoit, Jean-Charles Goeminne, Feby Ingriani Mardjuadi, Jean-Pascal Machiels, Jean-Luc Canon, Nicolas Meert

Publikováno v: Journal of Clinical Oncology. 30:e14060-e14060

e14060 Background: The addition of anti Epidermal Growth Factor Receptor (EGFR) monoclonal antibodies (mabs) to preoperative chemoradiation in RC has produced low pathological complete response (pCR) rate. The postulated reasons for the poor outcome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea74a89a8a193edde814a0e382b327fb
https://doi.org/10.1200/jco.2012.30.15_suppl.e14060

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Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: GORTEC 2008-02

Autor: Lionnel Geoffrois, M-C. Kaminsky-Forrett, Sylvie Zanetta, Emmanuelle Bompas, Anne Moxhon, Stéphanie Henry, Joël Guigay, J. H. Machiels, Sandra Schmitz

Publikováno v: Journal of Clinical Oncology. 28:5500-5500

5500 Background: Insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the growth and apoptosis of cancer cells, and is overexpressed in squamous cell carcinoma of the head and ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6802f0f387595e6a46d064dcdf3f1581
https://doi.org/10.1200/jco.2010.28.15_suppl.5500

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