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pro vyhledávání: '"Moustafa Ghanem"'
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
Autor:
Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its
Externí odkaz:
https://doaj.org/article/b489a67fc20044dc9afd570c0e341aec
Autor:
Jorge Franco, Francesco Piacente, Melanie Walter, Simone Fratta, Moustafa Ghanem, Andrea Benzi, Irene Caffa, Alexander V. Kurkin, Andrea Altieri, Patrick Herr, Macarena Martínez-Bailén, Inmaculada Robina, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 855 (2022)
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resi
Externí odkaz:
https://doaj.org/article/3955bfbf6c32440698b24b3e27358897
Autor:
Francesca Valdemarin, Irene Caffa, Angelica Persia, Anna Laura Cremonini, Lorenzo Ferrando, Luca Tagliafico, Alberto Tagliafico, Ana Guijarro, Federico Carbone, Stefano Ministrini, Maria Bertolotto, Pamela Becherini, Tommaso Bonfiglio, Chiara Giannotti, Amr Khalifa, Moustafa Ghanem, Michele Cea, Marzia Sucameli, Roberto Murialdo, Valentina Barbero, Raffaella Gradaschi, Francesca Bruzzone, Consuelo Borgarelli, Matteo Lambertini, Claudio Vernieri, Gabriele Zoppoli, Valter D. Longo, Fabrizio Montecucco, Samir G. Sukkar, Alessio Nencioni
Publikováno v:
Cancers, Vol 13, Iss 16, p 4013 (2021)
In preclinical studies, fasting was found to potentiate the effects of several anticancer treatments, and early clinical studies indicated that patients may benefit from regimes of modified fasting. However, concerns remain over possible negative imp
Externí odkaz:
https://doaj.org/article/cb99c746396d4283bbd6a27a05d443eb
Publikováno v:
Sensors, Vol 12, Iss 10, Pp 13295-13332 (2012)
This paper presents a new methodology for collaborative sensor data management known as WikiSensing. It is a novel approach that incorporates online collaboration with sensor data management. We introduce the work on this research by describing the m
Externí odkaz:
https://doaj.org/article/5ca0ae956b454f8aa2330755bfc455ba
Publikováno v:
Sensors, Vol 8, Iss 6, Pp 3601-3623 (2008)
In this paper, we present a distributed infrastructure based on wireless sensors network and Grid computing technology for air pollution monitoring and mining, which aims to develop low-cost and ubiquitous sensor networks to collect real-time, large
Externí odkaz:
https://doaj.org/article/2071e59bdd6f4c8ab77985dcfdcc1796
Publikováno v:
Journal of Tourism, Hotels and Heritage. 5:195-217
Publikováno v:
Clinical Diabetology. 9:306-312
Background. The incidence of type 2 diabetes mellitus (T2DM) has increased over the past years and early identification and management of its complications especially diabetic kidney disease (DKD) is of great importance. T2DM and DKD are of multifact
Autor:
Jian-Fei Bai, Somi Reddy Majjigapu, Bernard Sordat, Sophie Poty, Pierre Vogel, Pilar Elías-Rodríguez, Antonio J. Moreno-Vargas, Ana T. Carmona, Irene Caffa, Moustafa Ghanem, Amr Khalifa, Fiammetta Monacelli, Michele Cea, Inmaculada Robina, Consuelo Gajate, Faustino Mollinedo, Axel Bellotti, Aimable Nahimana, Michel Duchosal, Alessio Nencioni
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
11 p.- 2 fig.-4 tab.-8 schem.-1 graph. abst.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases for which chemotherapy has not been very successful yet. FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acry
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases for which chemotherapy has not been very successful yet. FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4ff75c600149bbef14b882ef0bbb10
http://hdl.handle.net/10261/274793
http://hdl.handle.net/10261/274793
Publikováno v:
Nutrients, Vol 13, Iss 1665, p 1665 (2021)
Nutrients
Nutrients
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and gene expression. Since such processes are fundamental to support canc
Autor:
Amr Khalifa, Ana Guijarro, Asmaa Namatalla, Moustafa Ghanem, Matteo Lambertini, Alessio Nencioni, Irene Caffa
Publikováno v:
Cancer Research. 82:3020-3020
Periodic fasting enhances the activity of several chemotherapeutics, molecularly-targeted drugs, endocrine agents and immune checkpoint inhibitors. Identifying drugs that are approved for non-oncological conditions, but acquire antitumor properties t