Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Moustafa E. El-Araby"'
Autor:
Fatmah Ali S. Alasmary, Dalal A. Abdullah, Vijay H. Masand, Abir Ben Bacha, Abdelsattar Mansour Omar Ebeid, Moustafa E. El-Araby, Ahmed M Alafeefy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Quinoxalines are benzopyrazine derivatives with significant therapeutic impact in the pharmaceutical industry. They proved to be useful against inflammation, bacterial, fungal, viral infection, diabetes and other applications. Very recently, in Janua
Externí odkaz:
https://doaj.org/article/ffec69356bab4219b307daf6812c7f51
Autor:
Mohd Rehan, Firoz Ahmed, Mohammad Imran Khan, Hifzur Rahman Ansari, Shazi Shakil, Moustafa E. El-Araby, Salman Hosawi, Mohammad Saleem
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer therapy. Natural compounds known as catechins hav
Externí odkaz:
https://doaj.org/article/33075e6c8b4c43d68a639afe339dd7c7
Autor:
Abdelsattar M. Omar, Maan T. Khayat, Farid Ahmed, Yosra A. Muhammad, Azizah M. Malebari, Sara M. Ibrahim, Mohammad I. Khan, Dhaval K. Shah, Wayne E. Childers, Moustafa E. El-Araby
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Tirbanibulin (KX2-391, KX-01), a dual non-ATP (substrate site) Src kinase and tubulin-polymerization inhibitor, demonstrated a universal anti-cancer activity for variety of cancer types. The notion that KX2-391 is a highly selective Src kinase inhibi
Externí odkaz:
https://doaj.org/article/74f0539c28fe4afaab248255f807b3c2
Autor:
Moustafa E. El-Araby, Abdelsattar M. Omar, Sameh H. Soror, Stefan T. Arold, Maan T. Khayat, Hani Z. Asfour, Faida Bamane, Mahmoud A. Elfaky
Publikováno v:
Journal of Advanced Research, Vol 24, Iss , Pp 251-259 (2020)
NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘)ii The prime symbol (`) is used to distinguish between NS4A resid
Externí odkaz:
https://doaj.org/article/ac89ecf67fe74d4ca4ed1b10c55463c0
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Farid Ahmed, Mohammad I. Khan, Sara M. Ibrahim, Yosra A. Muhammad, Azizah M. Malebari, Thikryat Neamatallah, Moustafa E. El-Araby
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Structural changes of small-molecule drugs may bring interesting biological properties, especially in the field of kinase inhibitors. We sought to study tirbanibulin, a first-in-class dual Src kinase (non-ATP competitive)/tubulin inhibitor because th
Externí odkaz:
https://doaj.org/article/539bc391ade147b39a5632057cf3fa93
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Mahmoud A. Elfaky, Yosra A. Muhammad, Elaf A. Felemban, Khalid M. El-Say, Moustafa E. El-Araby
Publikováno v:
Heteroatom Chemistry, Vol 2022 (2022)
Chronic Hepatitis C is a global health threat and a silent killer. Regardless of the profound progress in preventing and treating this disease, research continues to discover new direct antiviral agents (DAAs), especially against novel targets. Our r
Externí odkaz:
https://doaj.org/article/320200ef08d44feba563a7dac4ce48f5
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 755-767 (2018)
In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors of the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5-lipoxygensase (5-LOX). Testing these compounds in a rat paw oedema mode
Externí odkaz:
https://doaj.org/article/1a678a5bfb394ae1990d7c15a6fbd205
Autor:
Tarek A. Ahmed, Khalid M. El-Say, Fathy I. Abd-Allah, Abdelsattar M. Omar, Moustafa E. El-Araby, Yosra A. Muhammad, Piyusha P. Pagare, Yan Zhang, Khadijah A. Mohmmad, Osheiza Abdulmalik, Martin K. Safo
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1148 (2021)
Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Me
Externí odkaz:
https://doaj.org/article/53b06f2a01054c37bbf3132feeae3703
Autor:
Fatmah A. S. Alasmary, Fatima S. Alnahdi, Abir Ben Bacha, Amr M. El-Araby, Nadine Moubayed, Ahmed M. Alafeefy, Moustafa E. El-Araby
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1143-1151 (2017)
Elevated blood glucose and increased activities of secreted phospholipase A2 (sPLA2) are strongly linked to coronary heart disease. In this report, our goal was to develop small heterocyclic compound that inhibit sPLA2. The title compounds were also
Externí odkaz:
https://doaj.org/article/8cab571f7d2242e7b0e008bc771b6d4d
Autor:
Abdelsattar M. Omar, Osheiza Abdulmalik, Mohini S. Ghatge, Yosra A. Muhammad, Steven D. Paredes, Moustafa E. El-Araby, Martin K. Safo
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1508 (2020)
Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia-induced HbS polymerization and the subsequent erythrocyte sickling have
Externí odkaz:
https://doaj.org/article/b3322b5bdc3b4c949d8736deafb25c05