Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Moustafa Algamal"'
Autor:
Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai, Ksenia V. Kastanenka
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)
Abstract Background Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep. Slow-wave activity (SWA) is a major restorative feature of NREM slee
Externí odkaz:
https://doaj.org/article/1e5e4e5bc1d94426a2b8318ad4669b2b
Autor:
Yee Fun Lee, Alyssa N. Russ, Qiuchen Zhao, Stephen J. Perle, Megi Maci, Morgan R. Miller, Steven S. Hou, Moustafa Algamal, Zhuoyang Zhao, Hanyan Li, Noah Gelwan, Zhe Liu, Stephen N. Gomperts, Alfonso Araque, Elena Galea, Brian J. Bacskai, Ksenia V. Kastanenka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse
Externí odkaz:
https://doaj.org/article/ab1d3dd5af70461fa37743a95753e2eb
Autor:
Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, Ksenia V. Kastanenka
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.
Externí odkaz:
https://doaj.org/article/9442891c7a3244869aae495ba0e754c4
Autor:
Andrew Pearson, Rosa Ajoy, Gogce Crynen, Jon M. Reed, Moustafa Algamal, Michael Mullan, Dushyant Purohit, Fiona Crawford, Joseph O. Ojo
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-20 (2020)
Abstract Background The ventricular system plays a vital role in blood-cerebrospinal fluid (CSF) exchange and interstitial fluid-CSF drainage pathways. CSF is formed in the specialized secretory tissue called the choroid plexus, which consists of epi
Externí odkaz:
https://doaj.org/article/7cedadd4d11b4889959e33d3f7595aeb
Autor:
Joseph O. Ojo, Gogce Crynen, Moustafa Algamal, Prashanti Vallabhaneni, Paige Leary, Benoit Mouzon, Jon M. Reed, Michael Mullan, Fiona Crawford
Publikováno v:
ASN Neuro, Vol 12 (2020)
No concerted investigation has been conducted to explore overlapping and distinct pathobiological mechanisms between repetitive mild traumatic brain injury (r-mTBI) and tau/amyloid proteinopathies considering the long history of association between T
Externí odkaz:
https://doaj.org/article/2546992337674853bc38fdef598eec08
Autor:
Joseph O. Ojo, Moustafa Algamal, Paige Leary, Laila Abdullah, Benoit Mouzon, James E. Evans, Michael Mullan, Fiona Crawford
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Repetitive mild traumatic brain injury (rmTBI) is a major epigenetic risk factor for Alzheimer’s disease (AD). The precise nature of how rmTBI leads to or precipitates AD pathology is currently unknown. Numerous neurological conditions have shown a
Externí odkaz:
https://doaj.org/article/c9130f6e7c6746f193078e5bf006be92
Autor:
Joseph O. Ojo, Moustafa Algamal, Paige Leary, Laila Abdullah, Benoit Mouzon, James E. Evans, Michael Mullan, Fiona Crawford
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Repetitive mild traumatic brain injury (mTBI) is a risk factor for the development of neurodegenerative diseases such as chronic traumatic encephalopathy typified by immunoreactive tau aggregates in the depths of the sulci. However, the underlying ne
Externí odkaz:
https://doaj.org/article/e47ba9eb80ac4c7898990e3e9c87f736
Autor:
Joseph O. Ojo, Gogce Crynen, Jon M. Reed, Rosa Ajoy, Prashanthi Vallabhaneni, Moustafa Algamal, Paige Leary, Naomi G. Rafi, Benoit Mouzon, Michael Mullan, Fiona Crawford
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Plasma biomark
Externí odkaz:
https://doaj.org/article/959ebf48c91f4c688d3a3f36b2a9c8e9
Autor:
Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzon, David M. Diamond, Michael Mullan, Fiona Crawford
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Incidence of post-traumatic stress disorder (PTSD) ranges from 3 to 30% in individuals exposed to traumatic events, with the highest prevalence in groups exposed to combat, torture, or rape. To date, only a few FDA approved drugs are available to tre
Externí odkaz:
https://doaj.org/article/382061d07a84427193ffa7d9de57f42c
Autor:
Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, Ksenia V. Kastanenka
Alzheimer’s disease (AD) is characterized by synaptic loss and neuronal network dysfunction. These network deficits are mediated by early alterations in neuronal firing rates that coincide with amyloid plaque accumulation. Mounting evidence support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b681277b73f949d1adcccc58f21714
https://doi.org/10.1101/2022.04.27.489759
https://doi.org/10.1101/2022.04.27.489759
