Rational design, synthesis and computational studies of multi-targeted anti-Alzheimer’s agents integrating coumarin scaffold

Autor: Abd El-Mageed, Menna M.A., Fattah Ezzat, Manal Abdel, Moussa, Shaimaa A., Abdel-Aziz, Hatem A., Elmasry, Ghada F.

Publikováno v: In Bioorganic Chemistry January 2025 154

Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors

Autor: Metwally, Heba M., Abdelrasheed Allam, Heba, Baselious, Fady, Bonardi, Alessandro, Seif, Emad M., Moussa, Shaimaa A., Abdel-Latif, Ehab, Supuran, Claudiu T., Ibrahim, Hany S.

Publikováno v: In Bioorganic Chemistry June 2023 135

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Rational design, synthesis and computational studies of multi-targeted anti-Alzheimer's agents integrating coumarin scaffold.

Autor: Abd El-Mageed MMA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt., Fattah Ezzat MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt. Electronic address: manal.salem@pharma.cu.edu.eg., Moussa SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt., Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Giza, P.O. Box 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University, Canal El Mahmoudia Street, 21648, Alexandria, Egypt., Elmasry GF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Dec 02; Vol. 154, pp. 108024. Date of Electronic Publication: 2024 Dec 02.