Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

Autor: Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray

Publikováno v: eLife, Vol 7 (2018)

High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of MYC oncogene occurs in nearly half of tumors. We demonstrate that ovarian cancer cells highly depend on MYC for maintaining their

Externí odkaz: https://doaj.org/article/28fdc67b84ee4b348cb7df68b272d1b0

Figure S1 from YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis

Autor: T.S. Karin Eisinger-Mathason, Jun Qi, Jennifer A. Perry, Mousheng Xu, Malay Haldar, Alison Grazioli, Md. Zahidul Alam, Paul M.C. Park, Kristy Weber, David Niedzwicki, Jennifer Shah, Gloria E. Marino, Avery C. Lee, Gabrielle E. Ciotti, Koreana Pak, Susan Chor, Shaun Egolf, Adrian Rivera-Reyes, Matthew A. Lawlor, Shuai Ye

Supplemental patient information from tissue microarray and additional quantitations.

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https://doi.org/10.1158/0008-5472.22419440.v1

Data from Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Autor: Kwok-Kin Wong, Jun Qi, Richard Possemato, George Miller, John T. Poirier, Christina Almonte, Kristen Labbe, Yuanwang Pan, Shuai Li, Val Pyon, Angeliki Karatza, Mousheng Xu, Alireza Khodadadi-Jamayran, Hon-Cheong So, Kai Zhao, Jiehui Deng, Ting Chen, Zhaoyuan Fang, Wei Wang, Michela Ranieri, Qingyuan Huang, Hua Zhang, Paula Zouitine, Kate E.R. Hollinshead, Catríona M. Dowling, Vladislav O. Sviderskiy, Hai Hu, Troy A. Luster, Wai-Lung Ng, Fei Li

Despite advancements in treatment options, the overall cure and survival rates for non–small cell lung cancers (NSCLC) remain low. While small-molecule inhibitors of epigenetic regulators have recently emerged as promising cancer therapeutics, thei

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https://doi.org/10.1158/0008-5472.c.6511969

Supplementary Data from Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Autor: Kwok-Kin Wong, Jun Qi, Richard Possemato, George Miller, John T. Poirier, Christina Almonte, Kristen Labbe, Yuanwang Pan, Shuai Li, Val Pyon, Angeliki Karatza, Mousheng Xu, Alireza Khodadadi-Jamayran, Hon-Cheong So, Kai Zhao, Jiehui Deng, Ting Chen, Zhaoyuan Fang, Wei Wang, Michela Ranieri, Qingyuan Huang, Hua Zhang, Paula Zouitine, Kate E.R. Hollinshead, Catríona M. Dowling, Vladislav O. Sviderskiy, Hai Hu, Troy A. Luster, Wai-Lung Ng, Fei Li

12 supplementary figures

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https://doi.org/10.1158/0008-5472.22425196.v1

Genome-wide association study identifies 48 common genetic variants associated with handedness

Autor: Inês Barroso, Gail Davies, H.-Erich Wichmann, Bjarke Feenstra, Peter Vollenweider, Nicholas J. Timpson, Alan F. Wright, Frank Geller, Gérard Waeber, John M. Starr, Benjamin M. Neale, George Davey Smith, Tõnu Esko, Ruth J. F. Loos, Andrew A. Hicks, Pedro Marques-Vidal, Dorret I. Boomsma, Harry Campbell, Zoltán Kutalik, David M. Evans, Scott D. Gordon, Eva Albrecht, Peter P. Pramstaller, Leena Peltonen, Jing Hua Zhao, Lavinia Paternoster, Thomas Hansen, Massimo Mangino, Fazil Aliev, Beate St Pourcain, Panos Deloukas, Heather A. Boyd, Guillaume Paré, Marco P. Boks, Monique M.B. Breteler, Jouke-Jan Hottenga, Xin Li, Kari Stefansson, Ian J. Deary, Jari Lahti, Inga Prokopenko, Nicholas Eriksson, Lili Milani, Nicholas J. Wareham, Jordan W. Smoller, Norman Klopp, Lynn Cherkas, Reedik Mägi, Margaret J. Wright, Peter Kraft, Jacques S. Beckmann, Brenda W.J.H. Penninx, Gabriel Cuellar-Partida, André G. Uitterlinden, Fernando Rivadeneira, Wendy L. McArdle, Johan G. Eriksson, Jiali Han, Jennifer E. Huffman, Andres Metspalu, J.M. Vink, Frank J. A. van Rooij, Christian Gieger, M. Arfan Ikram, Cecilia M. Lindgren, Aarno Palotie, Daniel I. Chasman, Joyce Y. Tung, Liang-Dar Hwang, David A. Hinds, Elisabeth Widen, Caroline Hayward, Michelle Luciano, Johannes H. Smit, Gonneke Willemsen, Dale R. Nyholt, Carolina Medina-Gomez, Nicole M. Warrington, Teemu Palviainen, Stacy Steinberg, Kay-Tee Khaw, Kevin S. O’Connell, Bettina Konte, Gudmar Thorleifsson, Eco J. C. de Geus, John P. Kemp, Mads Melbye, Mark I. McCarthy, Sarah E. Medland, Jaakko Kaprio, Cameron D. Palmer, Joel N. Hirschhorn, Ina Giegling, Scott Melville, Thomas Werge, Nicole Soranzo, Sigurdur H. Magnusson, Maris Teder-Laving, Hreinn Stefansson, Kauko Heikkilä, Cornelia M. van Duijn, David L. Duffy, Samuli Ripatti, Igor Rudan, Annette M. Hartmann, Ole A. Andreassen, Mari Nelis, Ozren Polasek, Vincent Mooser, Mousheng Xu, Eero Vuoksimaa, Katri Räikkönen, Nicholas G. Martin, Dan Rujescu, Tim D. Spector, Dawn M. Waterworth, Danielle M. Dick, Roel A. Ophoff

Publikováno v: Cuellar-Partida, G, Tung, J Y, Eriksson, N, Albrecht, E, Aliev, F, Andreassen, O A, Barroso, I, Beckmann, J S, Boks, M P, Boomsma, D I, Boyd, H A, Breteler, M M B, Campbell, H, Chasman, D I, Cherkas, L F, Davies, G, de Geus, E J C, Deary, I J, Deloukas, P, Dick, D M, Duffy, D L, Eriksson, J G, Esko, T, Feenstra, B, Geller, F, Gieger, C, Giegling, I, Gordon, S D, Han, J, Hansen, T F, Hartmann, A M, Hayward, C, Heikkila, K, Hicks, A A, Hirschhorn, J N, Hottenga, J-J, Huffman, J E, Hwang, L-D, Ikram, M A, Kaprio, J, Kemp, J P, Khaw, K-T, Klopp, N, Konte, B, Kutalik, Z, Lahti, J, Li, X, Loos, R J F, Luciano, M, Magnusson, S H, Mangino, M, Marques-Vidal, P, Martin, N G, McArdle, W L, McCarthy, M I, Medina-Gomez, C, Melbye, M, Melville, S A, Metspalu, A, Milani, L, Mooser, V, Nelis, M, Nyholt, D R, O'Connell, K S, Ophoff, R A, Palmer, C, Palotie, A, Palviainen, T, Pare, G, Paternoster, L, Peltonen, L, Penninx, B W J H, Polasek, O, Pramstaller, P P, Prokopenko, I, Raikkonen, K, Ripatti, S, Rivadeneira, F, Rudan, I, Rujescu, D, Smit, J H, Smith, G D, Smoller, J W, Soranzo, N, Spector, T D, Pourcain, B S, Starr, J M, Stefansson, H, Steinberg, S, Teder-Laving, M, Thorleifsson, G, Stefansson, K, Timpson, N J, Uitterlinden, A G, van Duijn, C M, van Rooij, F J A, Vink, J M, Vollenweider, P, Vuoksimaa, E, Waeber, G, Wareham, N J, Warrington, N, Waterworth, D, Werge, T, Wichmann, H-E, Widen, E, Willemsen, G, Wright, A F, Wright, M J, Xu, M, Zhao, J H, Kraft, P, Hinds, D A, Lindgren, C M, Magi, R, Neale, B M, Evans, D M & Medland, S E 2021, ' Genome-wide association study identifies 48 common genetic variants associated with handedness ', Nature Human Behaviour, vol. 5, pp. 59-70 . https://doi.org/10.1038/s41562-020-00956-y
Partida, G C, Tung, J Y, Eriksson, N, Albrecht, E, Aliev, F, Andreassen, O A, Barroso, I, Beckmann, J S, Boks, M P, Boomsma, D I, Boyd, H A, Breteler, M MB, Campbell, H, Chasman, D I, Cherkas, L F, Davies, G, de Geus, E JC, Deary, I J, Deloukas, P, Dick, D M, Duffy, D L, Eriksson, J G, Esko, T, Feenstra, B, Geller, F, Gieger, C, Giegling, I, Gordon, S D, Han, J, Hansen, T F, Hartmann, A M, Hayward, C, Heikkilä, K, Hicks, A A, Hirschhorn, J N, Hottenga, J-J, Huffman, J E, Hwang, L-D, Ikram, M A, Kaprio, J, Kemp, J P, Khaw, K-T, Klopp, N, Konte, B, Kutalik, Z, Lahti, J, Li, X, Loos, R JF, Luciano, M, Magnusson, S H, Mangino, M, Marques-Vidal, P, Martin, N G, McArdle, W L, McCarthy, M I, Medina-Gomez, C, Melbye, M, Melville, S A, Metspalu, A, Milani, L, Mooser, V, Nelis, M, Nyholt, D R, O’Connell, K S, Ophoff, R A, Palmer, C, Palotie, A, Palviainen, T, Pare, G, Paternoster, L, Peltonen, L, Penninx, B WJH, Polasek, O, Pramstaller, P P, Prokopenko, I, Raikkonen, K, Ripatti, S, Rivadeneira, F, Rudan, I, Rujescu, D, Smit, J H, Smith, G D, Smoller, J W, Soranzo, N, Spector, T D, St Pourcain, B, Starr, J M, Stefánsson, H, Steinberg, S, Teder-Laving, M, Thorleifsson, G, Stefansson, K, Timpson, N J, Uitterlinden, A G, van Duijn, C M, van Rooij, F JA, Vink, J M, Vollenweider, P, Vuoksimaa, E, Waeber, G, Wareham, N J, Warrington, N, Waterworth, D, Werge, T, Wichmann, H-E, Widen, E, Willemsen, G, Wright, A F, Wright, M J, Xu, M, Zhao, J H, Kraft, P, Hinds, D A, Lindgren, C M, Magi, R, Neale, B M, Evans, D M & Medland, S E 2020, ' Genome-wide association study identifies 48 common genetic variants associated with handedness ', Nature Human Behaviour . https://doi.org/10.1038/s41562-020-00956-y
Cuellar-Partida, G, Tung, J Y, Eriksson, N, Albrecht, E, Aliev, F, Andreassen, O A, Barroso, I, Beckmann, J S, Boks, M P, Boomsma, D I, Boyd, H A, Breteler, M M B, Campbell, H, Chasman, D I, Cherkas, L F, Davies, G, de Geus, E J C, Deary, I J, Deloukas, P, Dick, D M, Duffy, D L, Eriksson, J G, Esko, T, Feenstra, B, Geller, F, Gieger, C, Giegling, I, Gordon, S D, Han, J, Hansen, T F, Hartmann, A M, Hayward, C, Heikkilä, K, Hicks, A A, Hirschhorn, J N, Hottenga, J J, Huffman, J E, Hwang, L D, Ikram, M A, Kaprio, J, Kemp, J P, Khaw, K T, Klopp, N, Konte, B, Kutalik, Z, Lahti, J, Li, X, Loos, R J F, Luciano, M, Magnusson, S H, Mangino, M, Marques-Vidal, P, Martin, N G, McArdle, W L, McCarthy, M I, Medina-Gomez, C, Melbye, M, Melville, S A, Metspalu, A, Milani, L, Mooser, V, Nelis, M, Nyholt, D R, O’Connell, K S, Ophoff, R A, Palmer, C, Palotie, A, Palviainen, T, Pare, G, Paternoster, L, Peltonen, L, Penninx, B W J H, Polasek, O, Pramstaller, P P, Prokopenko, I, Raikkonen, K, Ripatti, S, Rivadeneira, F, Rudan, I, Rujescu, D, Smit, J H, Smith, G D, Smoller, J W, Soranzo, N, Spector, T D, Pourcain, B S, Starr, J M, Stefánsson, H, Steinberg, S, Teder-Laving, M, Thorleifsson, G, Stefánsson, K, Timpson, N J, Uitterlinden, A G, van Duijn, C M, van Rooij, F J A, Vink, J M, Vollenweider, P, Vuoksimaa, E, Waeber, G, Wareham, N J, Warrington, N, Waterworth, D, Werge, T, Wichmann, H E, Widen, E, Willemsen, G, Wright, A F, Wright, M J, Xu, M, Zhao, J H, Kraft, P, Hinds, D A, Lindgren, C M, Mägi, R, Neale, B M, Evans, D M & Medland, S E 2021, ' Genome-wide association study identifies 48 common genetic variants associated with handedness ', Nature Human Behaviour, vol. 5, no. 1, pp. 59-70 . https://doi.org/10.1038/s41562-020-00956-y
Nature Human Behaviour, 5, 1, pp. 59-70
Nature Human Behaviour, 5(1), 59-70. Nature Publishing Group
Nat Hum Behav
Nature Human Behaviour, 5(1), 59-70. Springer Nature
Nature Human Behaviour
Nat. Hum. Behav. 5, 59–70 (2021)
Nature Human Behaviour, 5, 59-70
Nature human behaviour 5(1), 59-70 (2021). doi:10.1038/s41562-020-00956-y
Cuellar-Partida, G, Deloukas, P, Kemp, J P, McArdle, W L, Paternoster, L, Davey Smith, G, Timpson, N J, Medland, S E & al., E 2020, ' Genome-wide association study identifies 48 common genetic variants associated with handedness ', Nature Human Behaviour, vol. 5, pp. 59–70 . https://doi.org/10.1038/s41562-020-00956-y

Handedness, a consistent asymmetry in skill or use of the hands, has been studied extensively because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986a1504a38fc87e9588fa425872923b
https://curis.ku.dk/portal/da/publications/genomewide-association-study-identifies-48-common-genetic-variants-associated-with-handedness(3aa476e7-e13d-48f1-af0d-544a2ee787fd).html