Zobrazeno 1 - 10
of 105 053
pro vyhledávání: '"Mouse model"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The compound NS5806 is a Kv4 channel modulator. This study investigated the chronic effects of NS5806 on cardiac hypertrophy induced by transverse aortic constriction (TAC) in mice in vivo and on neonatal rat ventricular cardiomyocyte hypert
Externí odkaz:
https://doaj.org/article/2953d5467b574c2aaa2c089310587c77
Autor:
Laura Ferré-González, Ángel Balaguer, Marta Roca, Artemis Ftara, Ana Lloret, Consuelo Cháfer-Pericás
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Alzheimer's disease (AD) is the most prevalent dementia, showing higher incidence in women. Besides, lipids play an essential role in brain, and they could be dysregulated in neurodegeneration. Specifically, impaired plasma lipid
Externí odkaz:
https://doaj.org/article/ba05f22238204ee781da24873d35d525
Autor:
Cuiyu Tan, Shuqiang Huang, Liying Xu, Tongtong Zhang, Xiaojun Yuan, Zhihong Li, Miaoqi Chen, Cairong Chen, Qiuxia Yan
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background Changes in the oxidative stress and lipid metabolism (OSLM) pathways play important roles in polycystic ovarian syndrome (PCOS) pathogenesis and development. Consequently, a systematic analysis of genes related to OSLM was conduct
Externí odkaz:
https://doaj.org/article/8a872c993a4843ceb9c03d72756583f3
Publikováno v:
Surgery Open Science, Vol 20, Iss , Pp 106-115 (2024)
Background: Postoperative pain following abdominal surgery is a significant obstacle to patient recovery, often necessitating high analgesic doses associated with adverse effects like cognitive impairment and cardiorespiratory depression. Reliable an
Externí odkaz:
https://doaj.org/article/eb7760aa414c485e978a8d2c8beb392f
Autor:
Toichiro Naito, Yoshiaki Yamanaka, Kotaro Tokuda, Naohito Sato, Takafumi Tajima, Manabu Tsukamoto, Hitoshi Suzuki, Makoto Kawasaki, Eiichiro Nakamura, Akinori Sakai
Publikováno v:
Bone & Joint Research, Vol 13, Iss 7, Pp 321-331 (2024)
Aims: The antidiabetic agent metformin inhibits fibrosis in various organs. This study aims to elucidate the effects of hyperglycaemia and metformin on knee joint capsule fibrosis in mice. Methods: Eight-week-old wild-type (WT) and type 2 diabetic (d
Externí odkaz:
https://doaj.org/article/6a344998e7ca4d499e8c115ab37dcc67
Autor:
Gyu Sik Jung, Taehwan Park, JeongYeop Ryu, Joon Seok Lee, Jung Dug Yang, Ho Yun Chung, Kang Young Choi
Publikováno v:
BioMedical Engineering OnLine, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract The effects of the novel synthetic peptide, A7-1, on wound healing and skin grafts were evaluated in a C57BL/6 mouse model. Two 15-mm wide circular skin excisions were made on the backs of mice and to each excision, 100 µM A7-1 or normal sa
Externí odkaz:
https://doaj.org/article/bb6656e171e9469f8afdb0922aa7a998
Autor:
G. V. Fattakhova, A. O. Makarova, M. V. Konovalova, E. I. Kashirina, O. D. Kotsareva, P. S. Okara, E. V. Matushevskaya, E. V. Svirshchevskaya
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 733-740 (2024)
Type I allergy is mediated by the formation of IgE antibodies to proteins secreted by nonreplicating microorganisms (plant pollen, house dust mites, etc.) that enter the mucous membranes in very low concentrations. The mechanisms and localization of
Externí odkaz:
https://doaj.org/article/8e680ad33a6c4642b4f46f6b54e1225c
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 7, Pp 553-570 (2024)
Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. GC is determined by multiple (epi)genetic and environmental factors; can occur at distinct anatomic positions of the stomach; and displays high heterogeneity, with different
Externí odkaz:
https://doaj.org/article/0f26bab976a74c029a4b420ac661447d
Autor:
K. A. Stark, G. Rinaldi, A. Costain, S. Clare, C. Tolley, A. Almeida, C. McCarthy, K. Harcourt, C. Brandt, T. D. Lawley, M. Berriman, A. S. MacDonald, J. E. Forde-Thomas, B. J. Hulme, K. F. Hoffmann, C. Cantacessi, A. Cortés
Publikováno v:
Animal Microbiome, Vol 6, Iss 1, Pp 1-19 (2024)
Abstract Mounting evidence of the occurrence of direct and indirect interactions between the human blood fluke, Schistosoma mansoni, and the gut microbiota of rodent models raises questions on the potential role(s) of the latter in the pathophysiolog
Externí odkaz:
https://doaj.org/article/00b9a9d991ae49ddba6d0fd576bc8ed2