Early neutrophilia marked by aerobic glycolysis sustains host 3 metabolism and delays cancer cachexia

Autor: Petruzzelli, M, Ferrer, M, Schuijs, MJ, Kleeman, SO, Mourikis, N, Hall, Z, Perera, D, Raghunathan, S, Vacca, M, Gaude, E, Lukey, MJ, Jodrell, DI, Frezza, C, Wagner, EF, Venkitaraman, AR, Halim, TYF, Janowitz, T

An elevated neutrophil–lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer we show that neutro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::8cef867b9c6cc349cb9784018e06ece1
http://hdl.handle.net/10044/1/95745

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Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.

Autor: Ferrer M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.; MRC Cancer Unit, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK., Mourikis N; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Davidson EE; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Kleeman SO; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Zaccaria M; University College London, London WC1E 6BT, UK., Habel J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Rubino R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Flint TR; Department of Oncology, CRUK Cambridge Institute, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK., Connell CM; Department of Oncology, CRUK Cambridge Institute, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK., Lukey MJ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., White EP; Department of Genetics, Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, NJ 08901, USA., Coll AP; Wellcome Trust-MRC Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Venkitaraman AR; MRC Cancer Unit, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; Institute for Molecular & Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore., Janowitz T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.; Northwell Health Cancer Institute, Northwell Health, New Hyde Park, NY 11042, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 18. Date of Electronic Publication: 2023 Feb 18.