Cephalopod-inspired jetting devices for gastrointestinal drug delivery.

Autor: Arrick G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Sticker D; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Ghazal A; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Lu Y; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Duncombe T; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Gwynne D; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Mouridsen B; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Wainer J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jepsen JPH; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Last TS; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Schultz D; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Hess K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Medina De Alba E; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Min S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Poulsen M; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Anker C; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Karandikar P; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Pedersen HD; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Collins J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Egecioglu NE; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Tamang S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Cleveland C; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Ishida K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Uhrenfeldt AH; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Kuosmanen J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Pereverzina M; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Hayward A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kirk RK; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., You S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Dalsgaard CM; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Gunnarsson SB; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Patsi I; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Bohr A; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Azzarello A; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Frederiksen MR; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Herskind P; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Li J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Roxhed N; Micro and Nanosystems, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden., Rahbek UL; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Water JJ; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark., Buckley ST; Global Research Technologies, Device and Delivery Solutions, Global Drug Discovery and Clinical Drug Development, Novo Nordisk A/S, Bagsværd, Denmark. spby@novonordisk.com., Traverso G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. cgt20@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. cgt20@mit.edu.

Publikováno v: Nature [Nature] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.