Machine-guided design of cell-type-targeting cis-regulatory elements.

Autor: Gosai SJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sgosai@broadinstitute.org.; Harvard Graduate Program in Biological and Biomedical Science, Boston, MA, USA. sgosai@broadinstitute.org.; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. sgosai@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. sgosai@broadinstitute.org., Castro RI; The Jackson Laboratory, Bar Harbor, ME, USA. rodrigo.castro@jax.org., Fuentes N; The Jackson Laboratory, Bar Harbor, ME, USA.; Harvard College, Harvard University, Cambridge, MA, USA., Butts JC; The Jackson Laboratory, Bar Harbor, ME, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA., Mouri K; The Jackson Laboratory, Bar Harbor, ME, USA., Alasoadura M; The Jackson Laboratory, Bar Harbor, ME, USA., Kales S; The Jackson Laboratory, Bar Harbor, ME, USA., Nguyen TTL; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Noche RR; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.; Yale Zebrafish Research Core, Yale School of Medicine, New Haven, CT, USA., Rao AS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Joy MT; The Jackson Laboratory, Bar Harbor, ME, USA., Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA., Reilly SK; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. steven.k.reilly@yale.edu.; Wu Tsai Institute, Yale University, New Haven, CT, USA. steven.k.reilly@yale.edu., Tewhey R; The Jackson Laboratory, Bar Harbor, ME, USA. ryan.tewhey@jax.org.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA. ryan.tewhey@jax.org.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA. ryan.tewhey@jax.org.

Publikováno v: Nature [Nature] 2024 Oct; Vol. 634 (8036), pp. 1211-1220. Date of Electronic Publication: 2024 Oct 23.

An IT-based self-checking system of spreadsheet exercises for learners with visual impairments.

Autor: Hiramatsu I; Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan., Mouri K; Faculty of Information Sciences, Hiroshima City University, Hiroshima, Japan., Penny K; Institute for Education, Community and Society, University of Edinburgh, Edinburgh, UK., Indurkhya B; Institute of Philosophy, Jagiellonian University, Cracow, Poland., Kaneko K; Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Publikováno v: Disability and rehabilitation. Assistive technology [Disabil Rehabil Assist Technol] 2024 Aug; Vol. 19 (6), pp. 2364-2376. Date of Electronic Publication: 2023 Nov 29.

Functional dissection of complex and molecular trait variants at single nucleotide resolution.

Autor: Siraj L; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Program in Biophysics, Harvard Graduate School of Arts and Sciences, Boston, MA, USA.; Harvard-Massachusetts Institute of Technology MD/PhD Program, Harvard Medical School, Boston, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Castro RI; The Jackson Laboratory, Bar Harbor, ME, USA., Dewey H; The Jackson Laboratory, Bar Harbor, ME, USA., Kales S; The Jackson Laboratory, Bar Harbor, ME, USA., Nguyen TTL; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Kanai M; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Berenzy D; The Jackson Laboratory, Bar Harbor, ME, USA., Mouri K; The Jackson Laboratory, Bar Harbor, ME, USA., Wang QS; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., McCaw ZR; Insitro, South San Francisco, California, USA., Gosai SJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Aguet F; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Illumina Artificial Intelligence Laboratory, Illumina, San Diego, CA, USA., Cui R; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vockley CM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lareau CA; Program in Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Gusev A; Harvard Medical School and Dana-Farber Cancer Institute, Boston, MA, USA., Jones TR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lander ES; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Sabeti PC; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Finucane HK; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA USA., Reilly SK; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA., Ulirsch JC; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Illumina Artificial Intelligence Laboratory, Illumina, San Diego, CA, USA., Tewhey R; The Jackson Laboratory, Bar Harbor, ME, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 06. Date of Electronic Publication: 2024 May 06.

Augmin complex activity finetunes dendrite morphology through non-centrosomal microtubule nucleation in vivo.

Autor: Zhang Y; German Center for Neurodegenerative Diseases (DZNE), Dynamics of Neuronal Circuits Group, Venusberg Campus 1 Building 99, 53127 Bonn, Germany., Sung HH; Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan., Ziegler AB; German Center for Neurodegenerative Diseases (DZNE), Dynamics of Neuronal Circuits Group, Venusberg Campus 1 Building 99, 53127 Bonn, Germany., Wu YC; Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan., Viais R; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain., Sánchez-Huertas C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain., Kilo L; German Center for Neurodegenerative Diseases (DZNE), Dynamics of Neuronal Circuits Group, Venusberg Campus 1 Building 99, 53127 Bonn, Germany., Agircan FG; German Center for Neurodegenerative Diseases (DZNE), Dynamics of Neuronal Circuits Group, Venusberg Campus 1 Building 99, 53127 Bonn, Germany., Cheng YJ; Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan., Mouri K; Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan., Uemura T; Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.; Center for Living Systems Information Science, Kyoto University., Lüders J; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain., Chien CT; Institute of Molecular Biology, Academia Sinica, 11529 Taipei, Taiwan., Tavosanis G; German Center for Neurodegenerative Diseases (DZNE), Dynamics of Neuronal Circuits Group, Venusberg Campus 1 Building 99, 53127 Bonn, Germany.; LIMES Institute, University of Bonn, 53115 Bonn, Germany.

Publikováno v: Journal of cell science [J Cell Sci] 2024 May 01; Vol. 137 (9). Date of Electronic Publication: 2024 May 10.

Association study of MIF promoter polymorphisms with suicide completers in the Japanese population

Autor: Shimmyo N, Hishimoto A, Otsuka I, Okazaki S, Boku S, Mouri K, Horai T, Takahashi M, Ueno Y, Shirakawa O, Sora I

Publikováno v: Neuropsychiatric Disease and Treatment, Vol Volume 13, Pp 899-908 (2017)

Naofumi Shimmyo,1 Akitoyo Hishimoto,1 Ikuo Otsuka,1 Satoshi Okazaki,1 Shuken Boku,1 Kentaro Mouri,1 Tadasu Horai,1 Motonori Takahashi,2 Yasuhiro Ueno,2 Osamu Shirakawa,3 Ichiro Sora1 1Department of Psychiatry, 2Division of Legal Medicine, Department

Externí odkaz: https://doaj.org/article/c9eb4c877d824ae08518bebbc45d2ad1