Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mourad Metioui"'
Autor:
Aida Marino, Jean-Paul Dehaye, Naima Chaib, Mourad Metioui, M Fernández, N Keskiner, Stéphanie Pochet
Publikováno v:
British Journal of Pharmacology. 136:568-580
The effect of trichloroethanol (TCEt), the active metabolite of chloral hydrate, on the intracellular concentration of calcium ([Ca(2+)](i)) was investigated in rat submandibular glands (RSMG) acini loaded with fura-2. TCEt (1 - 10 mM) increased the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b22c03d0566413f20e36058b6db4ab2
https://doi.org/10.1038/sj.bjp.0704745
https://doi.org/10.1038/sj.bjp.0704745
Endosomal Proteolysis of Internalized Insulin at the C-terminal Region of the B Chain by Cathepsin D
Publikováno v:
Journal of Biological Chemistry. 277:9437-9446
The endosomal compartment of hepatic parenchymal cells contains an acidic endopeptidase, endosomal acidic insulinase, which hydrolyzes internalized insulin and generates the major primary end product A(1--21)-B(1--24) insulin resulting from a major c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0df1230c8b4511eb4443bae00e7da92
https://doi.org/10.1074/jbc.m110188200
https://doi.org/10.1074/jbc.m110188200
Publikováno v:
Journal of Biological Chemistry. 274:33723-33731
We have investigated the relevant protease activity in rat liver, which is responsible for most of the receptor-mediated epidermal growth factor (EGF) degradation in vivo. EGF was sequentially cleaved by endosomal proteases at a limited number of sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de6801d07f8df2dd6352da5e04e72b8
https://doi.org/10.1074/jbc.274.47.33723
https://doi.org/10.1074/jbc.274.47.33723
Autor:
Mourad Metioui, Y Rodrig, Eduardo Alzola, Jean-Paul Dehaye, M Fernández, Arie Moran, David J. Fogarty, Laurence Lagneaux, Carlos Matute, Aida Marino
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1439:395-405
Epithelial cells were isolated from rat trachea by incubation of the organ in a calcium-free medium. The intracellular concentration of calcium ([Ca(2+)](i)) was measured with the calcium-sensitive fluorescent dye fura2. In resting conditions, the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696f0e68734c7dc65f66819cd8e55d4
https://doi.org/10.1016/s1388-1981(99)00111-0
https://doi.org/10.1016/s1388-1981(99)00111-0
Publikováno v:
Archives of Oral Biology. 44:S63-S66
A major obstacle in studying the physiological and biochemical processes of salivary secretion is the lack of a good ductal cell line model. HSY, an immortalised cell line originating from human parotid gland intercalated ducts, provides a possible m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee1b2fd2b6866c09d245f5ae42dfc3c
https://doi.org/10.1016/s0003-9969(99)90024-9
https://doi.org/10.1016/s0003-9969(99)90024-9
Autor:
Jean-Paul Dehaye, Elie Kabre, Carlos Matute, Arantza Pérez-Etxebarria, Mourad Metioui, Eduardo Alzola, Jose M. Macarulla, Aida Marino, Naima Chaib, David J. Fogarty
Publikováno v:
Journal of Biological Chemistry. 273:30208-30217
Isolated ductal cells of rat submandibular gland phospholipid pools were labeled with [3H]arachidonic acid (AA). The tracer was incorporated preferentially to phosphatidylcholine (46% of the lipidic fraction). Extracellular ATP induced the release of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcd4646f5692fe4d23bb605e3315598f
https://doi.org/10.1074/jbc.273.46.30208
https://doi.org/10.1074/jbc.273.46.30208
Publikováno v:
American Journal of Physiology-Cell Physiology. 271:C1546-C1555
ATP (1 microM-1 mM) increased the intracellular Ca2+ concentration ([Ca2+]i) in rat submandibular ductal cells. The dose-response curve was biphasic with a first plateau approximately 10 microM and a second increase at concentrations higher than 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28607bce3c95ba7016bf0aaa1de932cf
https://doi.org/10.1152/ajpcell.1996.271.5.c1546
https://doi.org/10.1152/ajpcell.1996.271.5.c1546
Publikováno v:
General Pharmacology: The Vascular System. 27:1041-1046
1. Caffeine did not affect by itself the amylase release, nor intracellular calcium concentration in rat pancreatic acini. 2. Concentration of caffeine higher than 1 mM inhibited the amylase released in response to the muscarinic agonist carbamylchol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d911bef9b78164b7b7cb5eb7dd91ea6
https://doi.org/10.1016/0306-3623(95)02133-7
https://doi.org/10.1016/0306-3623(95)02133-7
Autor:
A Elyamani, Eduardo Alzola, Arie Moran, Jean-Paul Dehaye, Mourad Metioui, Naima Chaib, Aida Marino, Hagai Amsallem
Publikováno v:
Journal of Cellular Physiology. 168:462-475
The effect of extracellular ATP on the intracellular calcium concentration ([Ca2+]i) in rat submandibular glands was tested. The dose-response curve for ATP was biphasic with a first increase in the 1-30 microM concentration range and a further incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb8966f64b377e1a80231d623777e38
https://doi.org/10.1002/(sici)1097-4652(199608)168:2<462::aid-jcp25>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199608)168:2<462::aid-jcp25>3.0.co
Publikováno v:
Journal of Cellular Physiology. 161:243-248
Rat submandibular glands were digested with crude collagenase, and the intracellular calcium concentration of the cellular suspension was measured using fura-2. In the absence of extracellular magnesium and calcium ([Ca2+]o), ATP had no effect; the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73539384caf3067332047163e052a869
https://doi.org/10.1002/jcp.1041610208
https://doi.org/10.1002/jcp.1041610208