Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Mourad, Chioua"'
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Autor:
Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias, José Marco-Contelles, Zrinka Kovarik
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 588 (2024)
Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood–brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research. These characteristics indicate it may serve as
Externí odkaz:
https://doaj.org/article/1e994057bca340fcb598ef7d7a44f256
Autor:
Beatriz Chamorro, Sara Izquierdo-Bermejo, Julia Serrano, Dimitra Hadjipavlou-Litina, Mourad Chioua, Francisco López-Muñoz, José Marco-Contelles, Ricardo Martínez-Murillo, María Jesús Oset-Gasque
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Cerebral ischemia is a condition affecting an increasing number of people worldwide, and the main cause of disability. Current research focuses on the search for neuroprotective drugs for its treatment, based on the molecular targets involve
Externí odkaz:
https://doaj.org/article/cfd84adb79f24477b7bc1bf3cf4176f0
Autor:
Beatriz Chamorro, Sara Izquierdo-Bermejo, María Dolores Martín-de-Saavedra, Francisco López-Muñoz, Mourad Chioua, José Marco-Contelles, María Jesús Oset-Gasque
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1364 (2023)
Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy. The abundance of information available on the molecular pathophysiology of
Externí odkaz:
https://doaj.org/article/7e23be5927b04988ba2eb609c819c3c5
Autor:
Carina Lemke, Joscha Christmann, Jiafei Yin, José M. Alonso, Estefanía Serrano, Mourad Chioua, Lhassane Ismaili, María Angeles Martínez-Grau, Christopher D. Beadle, Tatiana Vetman, Florian M. Dato, Ulrike Bartz, Paul W. Elsinghorst, Markus Pietsch, Christa E. Müller, Isabel Iriepa, Timo Wille, José Marco-Contelles, Michael Gütschow
Publikováno v:
ACS Omega, Vol 4, Iss 26, Pp 22161-22168 (2019)
Externí odkaz:
https://doaj.org/article/266dc0bdc6b74364bac17b0fdeeb44a1
Autor:
Rocío Fernández-Serra, Emma Martínez-Alonso, Alberto Alcázar, Mourad Chioua, José Marco-Contelles, Ricardo Martínez-Murillo, Milagros Ramos, Gustavo V. Guinea, Daniel González-Nieto
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7449 (2022)
Brain stroke is a highly prevalent pathology and a main cause of disability among older adults. If not promptly treated with recanalization therapies, primary and secondary mechanisms of injury contribute to an increase in the lesion, enhancing neuro
Externí odkaz:
https://doaj.org/article/6291a09f01744a41bf862b3333156613
Autor:
Emma Martínez-Alonso, Alejandro Escobar-Peso, Alicia Aliena-Valero, Germán Torregrosa, Mourad Chioua, Rocío Fernández-Serra, Daniel González-Nieto, Youness Ouahid, Juan B. Salom, Jaime Masjuan, José Marco-Contelles, Alberto Alcázar
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1186 (2022)
Nitrones are encouraging drug candidates for the treatment of oxidative stress-driven diseases such as acute ischemic stroke (AIS). In a previous study, we found a promising quinolylnitrone, QN23, which exerted a neuroprotective effect in neuronal ce
Externí odkaz:
https://doaj.org/article/5d0ddac6fefa4f3ebcbbfac8601dd46c
Autor:
Oset-Gasque, Beatriz Chamorro, Sara Izquierdo-Bermejo, María Dolores Martín-de-Saavedra, Francisco López-Muñoz, Mourad Chioua, José Marco-Contelles, María Jesús
Publikováno v:
Antioxidants; Volume 12; Issue 7; Pages: 1364
Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy. The abundance of information available on the molecular pathophysiology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6b63600f7cbc9247bf7fccf1eff6e89d
Autor:
José M. Alonso, Alejandro Escobar-Peso, Alejandra Palomino-Antolín, Daniel Diez-Iriepa, Mourad Chioua, Emma Martínez-Alonso, Isabel Iriepa, Javier Egea, Alberto Alcázar, José Marco-Contelles
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 861 (2021)
Cerebrovascular diseases such as ischemic stroke are known to exacerbate dementia caused by neurodegenerative pathologies such as Alzheimer’s disease (AD). Besides, the increasing number of patients surviving stroke makes it necessary to treat the
Externí odkaz:
https://doaj.org/article/4cea36c23b4c4e4c8f6cfe07236bf2f7
Autor:
Beatriz Chamorro, David García-Vieira, Daniel Diez-Iriepa, Estíbaliz Garagarza, Mourad Chioua, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque
Publikováno v:
Molecules, Vol 26, Iss 4, p 1127 (2021)
Herein, we report the neuroprotective and antioxidant activity of 1,1′-biphenyl nitrones (BPNs) 1–5 as α-phenyl-N-tert-butylnitrone analogues prepared from commercially available [1,1′-biphenyl]-4-carbaldehyde and [1,1′-biphenyl]-4,4′-dica
Externí odkaz:
https://doaj.org/article/da359c76ff77491a9ccd5da315b32911