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Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors.

Autor: de Araújo ACJ; Regional University of Cariri, Ceará, Brazil., Freitas PR; Regional University of Cariri, Ceará, Brazil., Araújo IM; Regional University of Cariri, Ceará, Brazil., de Oliveira Borges JA; Regional University of Cariri, Ceará, Brazil., Gonçalves SA; Regional University of Cariri, Ceará, Brazil., Paulo CLR; Regional University of Cariri, Ceará, Brazil., Almeida RS; Regional University of Cariri, Ceará, Brazil., de Moraes Oliveira-Tintino CD; Regional University of Cariri, Ceará, Brazil., de Araújo-Neto JB; Postgraduate Program in Biological Sciences, Biosciences Center, Federal University of Pernambuco, Recife, PE, 50740-570, Brazil., Dos Santos Nascimento IJ; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil., de Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil., da Silva-Júnior EF; Biological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil., de Aquino TM; Laboratory of Synthesis and Research in Medicinal Chemistry, Research Group On Therapeutic Strategies-GPET, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil., Junior FJBM; Paraiba State University, João Pessoa, PB, 58071-160, Brazil., Marinho ES; Laboratory of Chemistry of Natural and Synthetic Product, State University of Ceará, UECE, Fortaleza, CE, Brazil., Dos Santos HS; Laboratory of Chemistry of Natural and Synthetic Product, State University of Ceará, UECE, Fortaleza, CE, Brazil., de Alencar Menezes IR; Regional University of Cariri, Ceará, Brazil., Tintino SR; Regional University of Cariri, Ceará, Brazil., Coutinho HDM; Regional University of Cariri, Ceará, Brazil. hdmcoutinho@gmail.com., Braga MFBM; Regional University of Cariri, Ceará, Brazil.

Publikováno v: Current microbiology [Curr Microbiol] 2024 Aug 24; Vol. 81 (10), pp. 325. Date of Electronic Publication: 2024 Aug 24.

Meldrum's acid derivates are MepA efflux pump inhibitors: In vitro and in silico essays.

Autor: Araújo IM; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., Pereira RLS; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., de Araújo ACJ; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., Gonçalves SA; Department of Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., Tintino SR; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., Oliveira-Tintino CDM; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., de Menezes IRA; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil., Salamoni R; Department of Chemistry, Regional University of Blumenau (FURB), Itoupava Seca, Blumenau, Santa Catarina, Brazil., Begnini IM; Department of Chemistry, Regional University of Blumenau (FURB), Itoupava Seca, Blumenau, Santa Catarina, Brazil., Rebelo RA; Department of Chemistry, Regional University of Blumenau (FURB), Itoupava Seca, Blumenau, Santa Catarina, Brazil., Silva LED; Research, Federal University of Paraná-UFPR, Matinhos, Paraná, Brazil., Gurgel APAD; Department of Engineering and Environment, Federal University of Paraíba, João Pessoa, Paraíba, Brazil., Coutinho HDM; Department of Chemistry-Biology, Regional University of Cariri-URCA, Crato, Ceará, Brazil.

Publikováno v: Journal of basic microbiology [J Basic Microbiol] 2024 Feb; Vol. 64 (2), pp. e2300558. Date of Electronic Publication: 2023 Dec 18.

Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains.

Autor: de Araújo ACJ; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., Freitas PR; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., Araújo IM; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., Siqueira GM; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., de Oliveira Borges JA; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., Alves DS; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., Miranda GM; Instituto Gonçalo Moniz (IGM), Fiocruz Bahia, Salvador, Brazil., Dos Santos Nascimento IJ; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, Alagoas, Brazil., de Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, Alagoas, Brazil., da Silva-Júnior EF; Biological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil., de Aquino TM; Laboratory of Synthesis and Research in Medicinal Chemistry, Research Group on Therapeutic Strategies - GPET, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil., Junior FJBM; Laboratory of Synthesis and Drug Delivery, LSVM, Paraiba State University, João Pessoa, Paraíba, Brazil., Marinho ES; Laboratory of Chemistry of Natural and Synthetic Product, State University of Ceará, UECE, Fortaleza, Ceará, Brazil., Dos Santos HS; Laboratory of Chemistry of Natural and Synthetic Product, State University of Ceará, UECE, Fortaleza, Ceará, Brazil., Tintino SR; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil., Coutinho HDM; Laboratory of Microbiology and Molecular Biology, LMBM, Universidade Regional do Cariri, Crato, Brazil.

Publikováno v: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2024 Feb; Vol. 38 (1), pp. 84-98. Date of Electronic Publication: 2023 Aug 30.

Chemical composition and antibacterial effects of Etlingera elatior (Jack) R.M. Smith against Staphylococcus aureus efflux pumps.

Autor: de Sousa Ferreira F; Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, Recife, Brazil., de Araújo Neto JB; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil., de Morais Oliveira-Tintino CD; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil., de Araújo ACJ; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil., Ribeiro-Filho J; Oswaldo Cruz Foundation (Fiocruz), Fiocruz Ceará, Eusébio, CE, Brazil., Freitas PR; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil., Araújo IM; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil., Lima MA; Departamento de Biologia Molecular, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraíba, João Pessoa, Brazil., de Azevedo FR; Centro de Ciências Agrarias e da Biodiversidade, Federal University of Cariri - UFCA, Crato, CE, Brazil. Electronic address: roberto.azevedo@ufca.edu.br., Tintino SR; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil., Coutinho HDM; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil. Electronic address: hdmcoutinho@gmail.com., Navarro DMDAF; Departamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, Recife, Brazil.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2023 Dec 01; Vol. 386, pp. 110751. Date of Electronic Publication: 2023 Oct 10.