Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mounir Ghamali"'
Autor:
Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-10 (2017)
Abstract Background Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM1 and PIM2 inhibitors
Externí odkaz:
https://doaj.org/article/47ae367aa30840b08d531fb8afe3bb06
Autor:
Mounir Ghamali, Samir Chtita, Abdellah Ousaa, Bouhya Elidrissi, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Journal of Taibah University for Science, Vol 11, Iss 1, Pp 1-10 (2017)
This study gives a quantitative structure–activity relationship (QSAR) analysis of toxicity of phenols and thiophenols to Photobacterium phosphoreum, which is an important indicator for water quality. The chemical structures of 51 phenols and thiop
Externí odkaz:
https://doaj.org/article/b5223b07b9eb45b68c037db49f8c5441
Autor:
Samir Chtita, Mounir Ghamali, Abdellah Ousaa, Adnane Aouidate, Assia Belhassan, Abdelali Idrissi Taourati, Vijay Hariram Masand, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Heliyon, Vol 5, Iss 3, Pp e01304- (2019)
The quantitative structure-activity relationship (QSAR) of sixty 2-phenylimidazopyridines derivatives with anti-Human African Trypanosomiasis (anti-HAT) activity has been studied by using the density functional theory (DFT) and statistical methods. B
Externí odkaz:
https://doaj.org/article/e7992726e31d4951b1e9b565231d1b9f
Autor:
Mounir Ghamali, Samir Chtita, Rachid Hmamouchi, Azeddine Adad, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Journal of Taibah University for Science, Vol 10, Iss 4, Pp 534-542 (2016)
The DFT-B3LYP method, with the base set 6-31G (d), was used to calculate several quantum chemical descriptors of 44 substituted flavonoids. The best descriptors were selected to establish the quantitative structure activity relationship (QSAR) of the
Externí odkaz:
https://doaj.org/article/a900ee5c3d7a465c96a38a650b2dc65a
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 7, Iss 2 (2015)
DFT-B3LYP method, with the basis set 6-31G (d), was employed to calculate nine quantum chemical descriptors of 16 acridin-9-(10H)-ones substituted with amino or (1,3-benzothiazol-2-yl)-amino groups compounds. The above descriptors were used to establ
Externí odkaz:
https://doaj.org/article/ec64614fe16149e486820124250e8bb2
Autor:
Mounir Ghamali, A. Ousaa, Mohammed Bouachrine, Samir Chtita, Adnane Aouidate, B. Elidrissi, Assia Belhassan, Abdelali Idrissi Taourati, Tahar Lakhlifi
Publikováno v:
New Journal of Chemistry. 44:1747-1760
In silico modelling studies were executed on thirty two N-substituted oseltamivir derivatives as inhibitors of influenza virus H5N1. Robust validated quantitative structure–activity relationship (QSAR) approaches have been investigated to explore t
Autor:
Mounir Ghamali, Adib Ghaleb, Adnane Aouidate, Abdelouahid Sbai, A. Ousaa, Samir Chtita, M`barek Choukrad, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Letters in Drug Design & Discovery. 15:1211-1223
Autor:
Samir Chtita, Adnane Aouidate, Mounir Ghamali, Tahar Lakhlifi, Mohammed Bouachrine, A. Ousaa, B. Elidrissi
Publikováno v:
Advances in Physical Chemistry, Vol 2018 (2018)
To search for newer and potent antileishmanial drugs, a series of 36 compounds of 5-(5-nitroheteroaryl-2-yl)-1,3,4-thiadiazole derivatives were subjected to a quantitative structure-activity relationship (QSAR) analysis for studying, interpreting, an
Autor:
Tahar Lakhlifi, M’barek Choukrad, Adib Ghaleb, A. Ousaa, Samir Chtita, Mounir Ghamali, Adnane Aouidate, Abdelouahid Sbai, Mohammed Bouachrine
Publikováno v:
Structural Chemistry. 29:1609-1622
Kinase-related apoptosis-inducing kinase 2 (DRAK2) is a serine/threonine kinase and belongs to the death-associated protein kinase DPAK family, which is responsible for induction of apoptosis in many cell types. Thus, DRAK2 is regarded as a promising
Autor:
Abdelouahid Sbai, Tahar Lakhlifi, Mohammed Bouachrine, M’barek Choukrad, A. Ousaa, Adib Ghaleb, Adnane Aouidate, Mounir Ghamali
Publikováno v:
Computational Biology and Chemistry. 74:201-211
Proviral Integration site for Moloney murine leukemia virus-1 (PIM1) belongs to the serine/threonine kinase family of Ca2+-calmodulin-dependent protein kinase (CAMK) group, which is involved in cell survival and proliferation as well as a number of o