Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mounir A. Koussa"'
Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link. Here authors show that a single tip-link bond is more mechanically stable relative to c
Externí odkaz:
https://doaj.org/article/cedc8ced7e7c4b7984736d122c8d046c
Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The conversion of auditory and vestibular stimuli into electrical signals is initiated by force transmitted to a mechanotransduction channel through the tip link, a double stranded protein filament held together by two adhesion bonds in the middle. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5723c416dbf89b7dc181bc1c1d811915
https://doi.org/10.1038/s41467-021-21033-6
https://doi.org/10.1038/s41467-021-21033-6
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10367-10372
Protein detection and quantification play critical roles in both basic research and clinical practice. Current detection platforms range from the widely used ELISA to more sophisticated, and more expensive, approaches such as digital ELISA. Despite a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f443811e4d695f389d7e091426d0c17d
https://doi.org/10.1073/pnas.1708148114
https://doi.org/10.1073/pnas.1708148114
Our senses of hearing and balance rely on the extraordinarily sensitive molecular machinery of the inner ear to convert deflections as small as the width of a single carbon atom1,2 into electrical signals that the brain can process3. In humans and ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bdb988b1bac208984f332c8925b600
Publikováno v:
Nature methods
We introduce a nanoscale experimental platform that enables kinetic and equilibrium measurements of a wide range of molecular interactions by expanding the functionality of gel electrophoresis. Programmable, self-assembled DNA nanoswitches serve both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de98de33888e058f15d127667cb9c18
https://doi.org/10.1038/nmeth.3209
https://doi.org/10.1038/nmeth.3209
Publikováno v:
Methods. 67:134-141
Recent methods in DNA nanotechnology are enabling the creation of intricate nanostructures through the use of programmable, bottom-up self-assembly. However, structures consisting only of DNA are limited in their ability to act on other biomolecules.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee0865681779c291753e79d6c81997f
https://doi.org/10.1016/j.ymeth.2014.02.020
https://doi.org/10.1016/j.ymeth.2014.02.020
Publikováno v:
Neuron Glia Biology. 6:245-261
In adult olfactory nerves of mammals and moths, a network of glial cells ensheathes small bundles of olfactory receptor axons. In the developing antennal nerve (AN) of the moth Manduca sexta, the axons of olfactory receptor neurons (ORNs) migrate fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c161b7e0bb279d1838c980d5a0d0b0c
https://doi.org/10.1017/s1740925x11000081
https://doi.org/10.1017/s1740925x11000081
Publikováno v:
Biophysical Journal. 106(2)
Hair cells in the inner ear convert mechanical stimuli, in the vestibular and auditory systems, into electrical signals which can be processed by the brain. Hair cells are highly polarized with a unique elaboration of modified microvilli at their api
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37eb75789e0908e6a18dc5564cbd5b7
Publikováno v:
Hearing research. 311
Transmembrane channel-like (TMC) proteins 1 and 2 are necessary for hair cell mechanotransduction but their precise function is controversial. A growing body of evidence supports a direct role for TMC1 and TMC2 as components of the transduction compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71497a11a441cd5b191234a20180cca5
https://pubmed.ncbi.nlm.nih.gov/24423408
https://pubmed.ncbi.nlm.nih.gov/24423408
Publikováno v:
Biophysical Journal. 110:196a
Mechanical stimuli from sound and head movements are converted into electrical signals by hair cells of the inner ear. Key to this process are tip links, fine protein filaments that convey mechanical force to hair-cell transduction channels. Tip link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3985ca96f317ac72bdaa2f8a13883f96
https://doi.org/10.1016/j.bpj.2015.11.1090
https://doi.org/10.1016/j.bpj.2015.11.1090